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Öğe Acute myeloid leukemia detected on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography imaging in a patient with fever of unknown origin(ELSEVIER SCIENCE INC, 2011) Kara, P. Ozcan; Gedik, G. Kara; Sari, O.; Serdengecti, M.; Kaya, B.[Abstract not Available]Öğe Chronic myeloid leukemia detected on FDG PET/CT imaging in a patient with renal cell carcinoma(ELSEVIER DOYMA SL, 2013) Varoglu, E.; Kaya, B.; Sari, O.It is well known that hematopoietic cytokine stimulation can cause increased fluorodeoxyglucose (FDG) accumulation in bone marrow on PET/CT imaging, which simulates that seen in patients with bone marrow metastases. However, increased bone marrow FOG uptake can be caused by other etiologies. We report a patient with operated renal cell carcinoma had no history of hematopoietic cytokine stimulation. The FDG PET/CT images showed increased bone marrow FDG uptake, and the patient was diagnosed as chronic myeloid leukemia. This case revealed that increased FDG uptake on bone marrow may be related to neoplastic disease of the hematopoietic tissues. (C) 2012 Elsevier Espana, S.L. and SEMNIM. All rights reserved.Öğe Effect of phytoestrogen emodin on doxorubicin-induced cytotoxicity and apoptosis on tumorigenic MCF-7 and non-tumorigenic MCF-10A human breast cells(WILEY-BLACKWELL, 2014) Uyar, P.; Kaya, B.; Guray, T. N.[Abstract not Available]Öğe Effects of iloprost and piracetam in spinal cord ischemia-reperfusion injury in the rabbit(NATURE PUBLISHING GROUP, 2011) Kalkan, E.; Keskin, F.; Kaya, B.; Esen, H.; Tosun, M.; Kalkan, S. S.; Erdi, F.Study design: Experimental Study. Objectives: The aim of this study was to investigate the neuroprotective effects of iloprost and piracetam on spinal cord ischemia/reperfusion (I/R) injury in the rabbit. Settings: The Experimental Research Center of Selcuk University, Konya, Turkey. Methods: A total of 24 rabbits were divided into four groups of six rabbits each, as follows: group 1 (n = 6) sham, laparotomy only; group 2 (n = 6) I/R; group 3 (n = 6) I/R + iloprost; and group 4 (n = 6) I/R + piracetam. I/R was established in groups 2, 3 and 4. Subsequently, they were followed up neurologically for 24 h until the rabbits were killed; biochemical and histopathological examinations of samples from the spinal cord were carried out. Results: Neurological examination results were significantly better in the iloprost and piracetam groups compared with the I/R group (P<0.05). Neuroprotection was achieved with iloprost and piracetam by suppressing malondialdehyde (P<0.05), increasing glutathione peroxidase activity (P<0.05) and decreasing the xanthine oxidase level. In histopathological assessment, iloprost and piracetam groups were statistically different from the I/R group in terms of the number of apoptotic neurons in gray matter and white matter, as well as in terms of degenerated neurons and glial cells (P<0.05). No statistical difference was determined between the four groups in the number of degenerated glial cells (P>0.05). Conclusion: This study has shown that iloprost and piracetam have neuroprotective effects in I/R injury both neurologically and histopathologically because of inhibition of lipid peroxidation. Spinal Cord (2011) 49, 81-86; doi: 10.1038/sc.2010.76; published online 29 June 2010Öğe Epitrochlear and axillary lymph node visualization on FDG-PET/CT imaging in a patient with rheumatoid arthritis(ELSEVIER SCIENCE INC, 2011) Kara, P. Ozcan; Kaya, B.; Gedik, G. Kara; Sari, O.An 38 year-old female with oral tongue cancer was referred for FDG-PET/CT scan for evaluating axillary lymph nodes and restaging malignancy. Bilateral uptake of axillary and epitrochlear lymph nodes were observed on PET/CT imaging. The uptake pattern was unexpected for the patient with this malignancy and she had a history of rheumatoid arthritis. Additionally, the wrists were included in the field of view and showed elevated FDG uptake. In this case report, we report benign axillary and epitrochlear tracer uptake on FDG-PET/CT scan in a patient with a history of rheumatoid arthritis. (C) 2010 Elsevier Espana, S.L. and SEMNIM. All rights reserved.Öğe Evaluation of hepatic metabolic activity in non-alcoholic fatty livers on (18)FDG PET/CT(ELSEVIER DOYMA SL, 2013) Dostbil, Z.; Varoglu, E.; Serdengecti, M.; Kaya, B.; Onder, H.; Sari, O.Objective: The liver has been used as a reference organ for the assessment of abnormal F-18-fluoro-2-deoxy-D-glucose ((18)FDG) in the body. Some researchers found that hepatosteatosis significantly changed the hepatic (18)FDG uptake, while others did not. This study investigated whether the liver's (18)FDG uptake was affected by the diffuse fatty infiltration of the liver. Material and methods: A total of 156 cases were included in this study. Different patient groups were defined according to the liver Hounsfield unit (HU). The HU was calculated from an unenhanced CT, for all patients, and we calculated the mean standardized uptake value (STmean) and maximum standardized uptake value (SUNmax) on an (18)FDG PET scan. For this purpose, we placed regions of interest (ROIs) on the liver image. We statistically compared the SUVmean and SUVmax measured in the fatty liver patients and the control group. Results: The average SUVmean and SUVmax values were calculated as 2.58 +/- 0.66 and 3.94 +/- 1, respectively, in the patient group and 2.54 +/- 0.57 and 3.7 +/- 0.88, respectively, in the control group. We found the average SUVmean and SUVmax values in the fatty liver group and its subsets were not significantly different from the values in the control group (p > 0.05). We also did not find any statistically significant correlation between average liver density (HU) and the average SUV values (p > 0.05). Conclusion: Fatty infiltration may not have a significant effect on the liver's (18)FDG uptake. Thus, the liver may be used as a reference or comparator on (18)FDG PET scans in patients with fatty liver disease. (C) 2012 Elsevier Espana, S.L. and SEMNIM. All rights reserved.Öğe FDG PET/CT findings of thyrotoxicosis induced thymic hyperplasia associated to interferon(ELSEVIER DOYMA SL, 2013) Gedik, G. K.; Sari, O.; Kaya, B.; Varoglu, E.[Abstract not Available]Öğe An interesting contamination artifact appearing in I-(131) whole-body imaging after ablative therapy(ELSEVIER SCIENCE INC, 2011) Kara, P. Ozcan; Sari, O.; Gedik, G. Kara; Kocak, I.; Kaya, B.[Abstract not Available]Öğe Intramedullary Metastasis Detected With F-18 FDG-PET/CT(Elsevıer Doyma Sl, 2012) Sarı, O.; Kaya, B.; Kara Gedik, G.; Özcan Kara, P.; Varoğlu, E.We report F-18 FDG-PET/CT images of MRI-correlated spine metastasis from non-small cell lung cancer (NSCLC). A 50-yearold woman was admitted to hospital with shortness of breath, chest pain, back pain and hemoptysis. She had a diagnosis of nonsmall cell lung cancer by lung biopsy. F-18 FDG-PET/CT study was carried out for staging. PET/CT imaging showed a gross mass in the upper lobe of the right lung, mediastinal, right cervical and supraclavicular metastatic lymph nodes, liver metastasis and multiple bone and muscle metastasis. Also, there was an increased FDG uptake in the spine in the level of 11th thoracic vertebrae (SUVmax: 6.9). This focal lesion was an intramedullary metastasis. Correlation with MRI showed that intramedullary mass Fig. 1. A 50-year-old woman with a history of shortness of breath, chest pain, back pain and hemoptysis diagnosed as lung cancer. The patient was done PET/CT for initial imaging. PET/CT showed an increased FDG uptake in the spine at the level of 11th thoracic vertebrae (SUVmax: 6.9). This focal lesion was an intramedullary metastasis. ∗ Corresponding author. E-mail address: oktaysari@gmail.com (O. Sari). showed an heterogeneous contrast enhancement. This image was suggestive of malignant lesion (Figs. 1 and 2).Öğe Lymphangitic Carcinomatosis in the Nonsmall Cell Lung Cancer Detected on FDG-PET/CT(SPRINGER, 2012) Serdengecti, M.; Varoglu, E.; Kaya, B.; Sari, O.; Guler, T.; Ozbek, O.; Keskin, S.[Abstract not Available]Öğe Mercaptoacetyltriglycine Renal Scan for the Differential Diagnosis of Acute Tubular Necrosis and İnterstitial Nephritis Associated to Vancomycin(ELSEVIER DOYMA SL, 2012) Gedik, G. K.; Yılmaz, F.; Kaya, B.; Kara, P. O.; Sarı, O.The differential diagnosis of vancomycin associated renal toxicity includes acute tubular necrosis and interstitial nephritis. We report a case of vancomycin induced renal toxicity shown by Tc-99m mercaptoacetyltriglycine renal scan. Nephrotoxicity was evolved secondary to vancomycin used for treating a patient with meningitis. Tc-99m mercaptoacetyltriglycine renal scan may play a role in differentiation between acute tubular necrosis and tubulointerstitial nephritis of vancomycin associated renal toxicity and can facilitate the clinical decision making. (C) 2011 Elsevier Espana, S.L. and SEMNIM. All rights reserved.Öğe The Role of FDG-PET/CT in Ovarian Cancer Patients with High Tumor Markers or Suspicious Lesion on Contrast-Enhanced Ct in Evaluation of Recurrence and/or in Determination of Intraabdominal Metastases(ELSEVIER SCIENCE INC, 2012) Sarı, O.; Kaya, B.; Özcan Kara, P.; Kara Gedik, G.; Çelik, C.; Özbek, O.; Serdengeçti, M.Objectives: This retrospective study was designed to investigate the role of fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in determination of recurrence and/or intraabdominal metastasis in patients with ovarian cancer having increased tumor markers or suspicious lesion detected by a contrast-enhanced abdominal CT (ceCT). Materials and methods: A total of 34 female patients who were treated for histopathologically proven ovarian cancer, underwent PET/CT examination for restaging and suspected recurrence. Patients with pathology report, tumor marker levels, ceCT and PET/CT performed within one month were included in the study. Results: A total of 34 patients were included in the study. 25 of 34 patients had high tumor marker (CA 125) level. The remaining 9 patients had suspected recurrence on ceCT imaging with normal tumor marker levels. Recurrence was confirmed by re-operation and biopsy (n = 4), clinical and imaging follow-up (n = 21) in 25 patients with elevated tumor markers. Recurrent disease was not shown in 5 of 25 patients on ceCT imaging and 1 of 25 patients on PET/CT imaging with high CA125 values. Both ceCT and PET/CT revealed recurrent disease in 19 of 25 patients. PET/CT showed more lesions in 11 of 19 patients. Sensitivity, specificity and accuracy of the PET/CT were 96.1%, 100% and 97%, respectively. Conclusion: PET/CT is found as a beneficial method for detection of the recurrence, in patients with increased serum CA 125 level and negative CT findings or with normal CA 125 level and recurrence detected by CT which was performed due to clinical symptoms.Öğe The Value of FDG-PET/CT in the Post-Treatment Evaluation of Endometrial Carcinoma: A Comparison of PET/CT Findings with Conventional Imaging and CA 125 as a Tumour Marker(ELSEVIER DOYMA SL, 2012) Özcan Kara, P.; Kara, T.; Kaya, B.; Kara Gedik, G.; Sarı, O.Objectives: This retrospective study was designed to assess the value of positron emission tomography/computed tomography imaging (PET/CT) in the post-treatment evaluation of the patients with endometrial carcinoma and to compare PET/CT scan with conventional imaging (Cl) including computed tomography (CT), ultrasonography (US) and magnetic resonance imaging (MRI) and CA 125 with both 20 U/ml and 35 U/ml cut-off values. Materials and methods: A total of 31 patients who were treated for histopathologically proven endometrial adenocarcinoma, underwent PET/CT examination for restaging and suspected recurrence. Thirty five PET/CT studies were performed in 31 patients. Lesion status was determined on the basis of clinical follow-up including radiological imaging (follow-up CT scan) at least 6 months and response to therapy. Results: Of the 35 PET/CT studies, 13 (37%) studies were positive, whereas 22 (63%) of them were negative. On study-based analysis the overall sensitivity, specificity, accuracy for PET/CT imaging were 100%, 96% and 97%, respectively. The corresponding information for Cl were 46%, 87% and 74%, for CA 125 (cut off= 20 U/ml) measurement were 45%, 88% and 74%, and for CA 125 (cut off = 35 U/ml) measurement were 27%, 100% and 78%, respectively. On lesion-based analysis, PET/CT revealed only one false positive case. In none of 21 patients with negative 22 PET/CT studies, no subsequent clinical or radiological recurrences were observed with a follow-up of at least 6 months. Conclusion: FDG-PET/CT is found more useful modality than CI and CA 125 in the evaluation of post-treatment endometrial carcinoma patients, for suspected recurrence.
