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    Evaluation of Electrocardiographic and Echocardiographic Findings In Patients Diagnosed with Polycythemia Vera and Essential Thrombocythemia
    (Selçuk Üniversitesi, 2024 Şubat) Kaya, Bahattin Engin; Demircioğlu, Sinan; Tekinalp, Atakan; Sertdemir, Ahmet Lütfi; Ergün, Mustafa Çağrı; Tuna, Ali Kürşat; Kandemir, Şerif Ahmet; İçli, Abdullah; Çeneli, Özcan
    ABSTRACT Background/Aims: Polycythemia vera (PV) and essential thrombocythemia (ET) are chronic myeloproliferative diseases that can lead to various clinical outcomes, including arterial and venous thrombosis, pulmonary hypertension, and myocardial infarction. This study was designed to assess the cardiac effects of these diseases using electrocardiography and echocardiography. Methods: A total of 50 patients diagnosed with PV, 50 patients diagnosed with ET, and 50 healthy individuals forming the control group were enrolled in this study. Demographic information for all subjects was collected. Electrocardiography (ECG) recordings and standard transthoracic echocardiographic examinations were conducted for all patients and control subjects. Pulse wave velocity (PWV) measurements were assessed using a Holter blood pressure device. Results: In total, 50 PV patients, 50 ET patients, and 50 control group were included in the study. The demographic characteristics of the PV, ET and control groups were similar. The PR interval was significantly shorter in control subjects than in PV and ET patients (p = 0.007, p = 0.024). Although the measured values were within normal limits, diastolic posterior wall thickness was significantly lower in the control group compared to PV and ET patients (p = 0.019, p = 0.009). PWV was significantly higher in ET patients compared to the control group (p = 0.012). Conclusion: ECG parameters used to predict ventricular arrhythmias (QT, QTc, Tp-Te, Tp-Te/QT) and Pulmonary Artery Pressure showed no significant change, in opposition to existing literature. Nonetheless, similar to previous publications, PV and ET were found to negatively affect the diastolic function parameters on transthoracic echocardiography. While the aortic stiffness was significantly higher in ET patients compared to the control group, no significant difference was noted between PV patients and control subjects in terms of aortic stiffness.