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  • Küçük Resim
    Öğe
    Clomipramine Versus Sertraline in the Treatment of Obsessive Compulsive Disorder
    (1999) Askin, R.; Turan, M.; Cilli, A. S.; Kaya, N.
    Objective: The aim of this study was to compare the efficacy, safety, and tolerability of sertraline and clomipramine in the treatment of obsessive-compulsive disorder (OCD). Method: Outpatients met the DSM-IV criteria for OCD for 1 year or longer and scores of ? 20 on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and ? 4 on the Clinical Global Impression Severity Scale (CGI-S) were included in the study. Patients who had significant concomitant physical disease, suicidal tendency, a history of seizure or organic brain disorder, substance abuse within the previous sixth months, DSM-IV axis I diagnoses other than OCD and who had had medication for 1 month were not included in the study. Patients were randomized to receive 8-week of single-blind treatment with either fixed dose of sertraline (n=20) 50 mg/day or clomipramine (n=22) initially 50 mg/day and 150 mg/day after 1 week. No additional medication was given to patients. Clinical evaluations were conducted before the treatment and on two-week schedule throughout the 8-week trial using the Y-BOCS and theCGI-S. Results: Four of clomipramine (18.2%) and 2 of sertraline (10.0%) patients dropped out because of adverse events or lack of effectiveness. Thirty six patients completed the trial (sertraline n=18; clomipramine n=18). The mean baseline Y-BOCS and CGI-S scores were 24.95 and 4.75 respectively for sertraline and 23.54 and 4.85 for clomipramine (p>0.05). A significant reduction in OCD symptoms from baseline to the end of 8 th week of the trial was found in both sertraline and clomipramine treated groups (p<0.05). Mean baseline to final visit changes were -69.06% (Y-OBCS) and -65.75% (CGI-S) for sertraline and -69.26% (Y-OBCS) and -53.78% (CGI-S) for clomipramine (p>0.05). The number of patients withdrawn because of adverse events was substantially greater for clomipramine (22.2%) than sertraline (11.1%). The incidence of side effects was significantly higher in clomipramine-treated patients versus sertraline-treated patients. The most frequent adverse events with sertraline were headache (38.8%), nausea (33.3%), irritability (11.1%) and tremor (11.1%), while clomipramine was most commonly associated with dry mouth (50%), weight gain (50%), constipation (27.7%), yawning (27.7%), sedation (22.2%) and dizziness (11.1%). Conclusions: At fixed doses, both clomipramine and sertraline showed a similar therapeutic efficacy in the treatment of OCD. Clomipramine produced more side effects and dropout rate. The results indicate that sertraline is as effective as clomipramine in the treatment of OCD and is better tolerated.
  • Küçük Resim Yok
    Öğe
    Orta ve Yükseköğrenim Öğrencilerinde Sosyal Fobik Belirti Yaygınlığı
    (1997) Kaya, N.; Çilli, A. S.; Aşkın, R.; Herken, H.; Özkan, İ.; Kucur, R.
    Amaç: Bu çalışmada orta, lise ve üniversite öğrencilerinde sosyal fobik belirtilerin yaygınlığı ve sosyo-demografik özelliklerle ilişkisinin araştırılması amaçlandı. Yöntem: Çalışma 733’ü kız, 920’si erkek, toplam 1653 öğrenci üzerinde gerçekleştirildi. Öğrencilere sosyo-demografik özellikleri saptamak için araştırmacılar tarafından geliştirilen bir form ile Uluslararası Bileşik Tanı Görüşmesinin sosyal fobi alt bölümü ve anne-baba tutum ölçeği verildi. İstatistiksel analizlerde ki kare testi kullanıldı. Bulgular: Öğrencilerin % 24.2’sinde sosyal fobik belirtiler saptandı. Sosyal fobik belirtilerin kızlarda, orta okulda okuyanlarda, sosyo-ekonomik durumu kötü olanlarda, 1. derece akrabalarında sosyal fobik belirti bildirenlerde ve sigara veya alkol-ilaç kötüye kullanımı olanlarda daha yüksek oranda olduğu bulundu. Sonuç: Sosyal fobi, gençlik döneminde beklenenden yüksek sıklıkta görülmesi, gençlerin derslerdeki ve sosyal ilişkilerdeki başarılarını olumsuz yönde etkilemesi ve ikincil alkol ve madde kullanımına yol açması nedenleriyle önemli bir psikiyatrik hastalıktır.