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  • Küçük Resim Yok
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    Efficacy of aprotinin treatment on bilateral blunt chest trauma created in rab
    (2013) Kaya H.; Kafali M.E.; Aydin K.; Kocak S.; Sahin M.; Duran A.; Gul M.
    Objectives: To investigate the effects of aprotinin, on blood gasses, oxidant-antioxidant status, and lung histopathology in an experimental bilateral blunt chest trauma model. Methods: Conducted at the Experimental Animal Laboratory of Meram Medical School at Selcuk University, Konya, Turkey, the study comprised 21 New Zealand female albino rabbits who were divided into three groups. Trauma was applied on the sham and aprotinin groups, which was administered intravenous Aprotinin 20.000 U/kg. Arterial blood samples were obtained from all rabbits at hours 0, 3, 24, and 96. At hour 96 after trauma, all rabbits were sacrificed using the decapitation method, and then blood and lung tissue samples were obtained. Blood nitric oxide, malondialdehyde and blood gas measurements were made. Histopathological changes in the lung were examined with a light microscope. Results: While no positive effect of aprotinin was observed on nitric oxide malondialdehyde and partial pressure of carbon dioxide values, it was seen to have an increasing effect on partial oxygen pressure level. Aprotinin had a partial effect on lung histopathology. Conclusion: Aprotinin was determined to have a positive effect on PO2 levels. We could not find any positive effects especially on alveolar haemorrhage.
  • Küçük Resim
    Öğe
    Seropositivity of chlamydia pneumoniae in acute ischemic stroke [Akut i?skemi?k strokta chlamydi?a pneumoniae seropozi?fli??i?]
    (Turkish Society of Cerebrovascular Diseases, 2004) Gül M.; Duran A.; Kaya H.; Uca A.U.
    BACKROUND: The aim of our study was to investigate a relation between Acute Ischemic Stroke (AIS) and Chlamydia pneumoniae (CP). METHODS: The study was performed as a clinical prospective study. Totally, 104 healthy volunteers [76 male (73%), 28 female (27%), aged 64±14 years old] and 126 patients with AIS [64 female (51%), 76 male (73%), aged 67±14 years old] applied to Emergency department of Meram Medical School, Selcuk University, between January 01, 2001 and December 31, 2001 were studied. The patients and the controls were compared in respect to their CP seropositivity (CP IgG and CP IgA antibodies). RESULTS: The seropositivity of CP IgA and CP IgG was statistically significant in the patients group compared to that of the control group (p=0. 006 and p=0.001 respectively). CONCLUSION: Our results implies a relation between CP and AIS. Possibility of such a relation deeds to be more investigated.