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    Interferon alpha induced mania in a patient with malign melanoma: Case report [?terferon alfa kullanan malign melanomlu bir hastada ortaya çikan mani: Olgu sunumu]
    (2008) Kaya N.; Zeytinci, İsmet Esra; Şahingöz M.
    Interferon alpha is commonly used in the treatment of several diseases because of their stimulating effects on immune response, such as viral hepatitis, malign melanoma and multiple sclerosis. It was reported that IFN-a induce neuropsychiatric side effects such as depression, anxiety, psychosis, mania, suicidal ideation, somnolence and delirium in addition to flue like symptoms including weakness, fever, headache and myalgia. In this paper was presented a case of IFN-? induced mania in a patient treated for malign melanoma and with the family history of bipolar disorder.
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    Psychiatric symptoms and quality of life in Behçet patients [Behçet hastalarinda ruhsal belirtiler ve yaşam kalitesi]
    (2006) U?uz F.; Dursun R.; Kaya N.; Çili A.S.
    Objective: The aim of this study was to investigate psychiatric symptoms, quality of life, and the factors associated with quality of life in patients with Behçet disease. Methods: The study sample was formed by consecutive 73 Behçet patients who admitted to a Behçet outpatient clinic of a university hospital, and 34 healthy subjects matched for age, gender, educational level, and marital status. The patients and control groups were assessed with Symptom Check List-90-Revised Version (SCL-90-R), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Quality of Life Index (WHOQOL-Brief). Results: There were no significant differences between patient and control groups with respect to gender, age, educational level and marital status. BDI, BAI and all subscale scores of SCL-90-R were significantly higher and physical and psychological health subscale scores of WHOQOL-Brief were significantly lower in Behçet patients compared to controls. No significant difference was found between the groups for social relationships and environment domains of quality of life. Female patients had lower physical health subscale scores of WHOQOL-Brief compared to male patients. A negative correlation was found between levels of psychiatric symptoms and all quality of life domains. Conclusion: The present study suggests that when compared with healthy subjects, Behçet patients have higher level of psychiatric symptoms, and they have lower level of quality of life in physical and psychological health domains. Psychiatric symptoms negatively influence the quality of life in Behçet patients. Therefore, psychiatric evaluation should be performed for all Behçet patients.