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  • Küçük Resim
    Öğe
    Diş hekimliği fakültesi öğrencilerinin el hijyeni inanç durumları ve etkileyen faktörler
    (Selçuk Üniversitesi, 2020) Kayar, Nezahat Arzu; Daloğlu, Mustafa; Şenol, Yeşim
    Amaç: Çalışma diş hekimliği öğrencilerinin el hijyeni inanç skalası ve el hijyeni uygulama envanterine verdikleri yanıtları ve etkileyen faktörleri değerlendirmeyi hedeflemektedir. Gereç ve Yöntemler: Araştırma 2019-2020 eğitim-öğretim döneminde Akdeniz Üniversitesi Diş Hekimliği Fakültesi’nde dördüncü ve beşinci sınıf öğrencileri ile birlikte yürütülen kesitsel nitelikte bir çalışmadır. Öğrenci sayısı 112’dir. Öğrencilere el hijyeni inanç skalası ve el hijyeni uygulama envanteri uygulanmıştır. İstatistiksel analizlerde farklılığın bulunması için t – test uygulanmıştır. Bulgular: Çalışmaya katılan öğrencilerin %53,6’sı kadın, %50’si beşinci sınıf öğrencisidir. El hijyeni inanç ölçeğinden kadın ve erkek öğrencilerin aldıkları ortalama puanlar açısından istatistiksel olarak anlamlı bir farklılık bulunmuştur. Benzer şekilde sınıf farklılığı ve kayıttan önce diş hekimine gitme ve gitmeme alışkanlığı el hijyeni envanterinden alınan puanı etkilemektedir. Sonuç: Diş hekimliği öğrencilerinin çoğunun el hijyeni inanç skalası ve el hijyeni uyum skalasından aldıkları puanlar ortalamanın üzerinde olmakla birlikte, düşük puan alan öğrencilerin olduğu da dikkat çekmektedir. Bu alana ilişkin derslerin eklenmesi ve öğrencilerin izlenmesi enfeksiyonların önlenmesi için önemlidir.
  • Küçük Resim
    Öğe
    Immune responses in women with periodontitis and preterm low birth weight: Levels of CD4+ and CD8+ T cells in gingival granulation tissue
    (Elsevier Ltd, 2020) Kayar, Nezahat Arzu; Çelik, İlhami; Alptekin, Nilgün Özlem
    Preterm Low-Birth-Weight (PLBW) is frequently associated with periodontal disease. However, the mechanism is still unknown. The present study was performed to examine the possible link between periodontal infections and PLBW in post-partum women utilizing clinical parameters and CD4+ and CD8 + T lymphocytes ratio in gingival granulation tissue. Materials: The tissues used in this study consisted of 35 gingival granulation tissue biopsies from 35 mothers of healthy infants (HTBW), 35 biopsies of gingival granulation tissue from 35 mothers of PLBW within one month postpartum and gingival tissue biopsies from 7 control individual with no periodontal disease (HC). CD4+ and CD8 + T lymphocyte ratios in a unit area of the gingival granulation tissue were determined by hystometrically. Statistical analysis was performed by using Kruskal-Wallis and Mann-Whitney U tests. Results: CD8 + T lymphocytes were more prevalent in the PLBW group than in the HTBW and HC group (P < 0.05). The CD4+/CD8+ ratio in the PLBW group was lower than those of the other groups (p < 0.05). There were no statistically significant differences in CD4 + T lymphocytes counts between all groups (P > 0.05). Conclusion: Within the limits of this study it can be concluded that CD8 + T lymphocytes in gingival tissue may play important roles in the pathogenesis of periodontitis and PLBW.
  • Küçük Resim Yok
    Öğe
    Interleukin-1 receptor antagonist levels in gingival crevicular fluid and serum in nonsmoking women with preterm low birth weight and intrauterine growth retardation
    (Dental Investigations Society, 2015) Kayar, Nezahat Arzu; Alptekin, Nilgün Özlem; Haliloğlu, Seyfullah
    Objective: The aim of this study was to evaluate interleukin (IL)-1 ? and IL-1 receptor antagonist (IL-1ra) levels in gingival crevicular fluid (GCF) and serum (S) in nonsmoking women with normal birth (NB), preterm low birth weight (PLBW), and intra-uterine growth retardation (IUGR). Materials and Methods: In this unmatched case-control study design, 64 women with NB, 45 women with PLBW, and 47 women with IUGR were recruited within 24 h delivery. Clinical periodontal parameters were recorded. IL-1 ? and IL-1ra levels in GCF (pg/30 s) and serum (pg/ml) of were evaluated using commercial enzyme immunoassay and ELISA kits. Results: Greater pocket depth and clinical attachment loss were observed in PLBW and IUGR women than in NB women (P < 0.05). The total amounts of IL-1ra and IL-? of GCF were higher levels in NB women than PLBW and IUGR women (P < 0.05). The lowest total amount of IL-1ra of GCF was found in IUGR women (P < 0.05). The concentrations of IL-1ra in serum samples were not statistically significant for any of the study groups (P > 0.05). Conclusion: It can be suggested that worse periodontal conditions and the low levels of IL-1ra in GCF may be an important factor in adverse pregnancy outcomes. © 2015 Dental Investigations Society.
  • Küçük Resim
    Öğe
    Methodological evaluation of gingival crevicular fluid volume and neutrophil elastase levels: sequential sampling, length of sampling time and two different sampling methods
    (TAYLOR & FRANCIS LTD, 2019) Kayar, Nezahat Arzu; Oduncuoğlu, Bahar Füsun; Haliloğlu, Seyfullah; Serpek, Behiç; Ataoğlu, Tamer; Alptekin, Nilgün Özlem
    Objectives: The mechanisms underlying the formation and composition of gingival crevicular fluid (GCF) and its flow into and from periodontal pockets are not understood very well. The aim of this study was to evaluate the length of sampling time and sequential sampling of GCF neutrophil elastase (NE) enzyme levels by using intracrevicular and orifice methods. Material and methods: Twenty adults (mean age of 41.8 years, ranged 31-60 years, 18 males and 2 females) with chronic periodontitis were enrolled and all completed the 3-d study. GCF was collected by both intracrevicular and intrasulcular methods, 720 samples of GCF were collected. In first, second and third day, the length of sampling time in seconds (s) and order were '5- 10-30-s'; '10- 30- 5-s' and '30- 5- 10-s,' respectively. GCF elastase levels were determined by hydrolysis of neutrophil specific substrate N-methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide. Results: NE activity (mu U) and NE activity/volume (mu U/mu l) were significantly different for order of sampling (p < .05), but not for the length of sampling time (p>.05). Conclusions: Within the limits of this study, the choice of sampling technique in GCF-profile studies seems to be a critical decision as it has the potential to affect the GCF volume and NE activity.