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Öğe Add-on therapy with pramipexole in treatment resistant dysthymic disorder: A case report(KURE ILETISIM GRUBU A S, 2009) Zeytinci, Esra; Uguz, Faruk; Sahingoz, Mine; Sari, Serap; Kayhan, FatihAdd-on therapy with pramipexole in treatment resistant dysthymic disorder: A case report Despite a wide range of alternative antidepressant drugs, a considerable rate of patients with dysthymic disorder do not response to these treatments. Usually combined pharmacological drugs and augmentation therapies are used to manage this chronic psychiatric disorder. Pramipexole, a new dopamine agonist, is approved for Parkinson's disease and restless leg syndrome but accumulating evidence suggests the usage of the drug as an antidepressant. We present a young man with a history of dysthymic disorder for 15 years who improved after adding low dose pramipexole to the prior treatment.Öğe Asemptomatik erişkin hastada insidental korpus kallosum agenezesi ve kolposefali(2016) Büyükgöl, Hüseyin; Güneş, Muzaffer; İlik, Faik; Kayhan, FatihKorpus kallozum, iki beyin yarımküresinde bulunan kortikal ve subkortikal nöronlar arasındaki bağlantıları sağlayan en büyük komissüral yapıdır. Korpus kallozum agenezesi genellikle prenatal dönemde veya erken çocukluk dönemde tanı alır. Mental ve motor retardasyon, nöbet, meningomyelosel gibi konjenital anomalilerle birlikte görülür. Bu yazıda, corpus kallozum agenezisi ve kolposefalisi olup hiç bir semptomu olmayan insidental olarak tanı konulan bir olgu bildirilmiştirÖğe Association of paraoxonase-1 activity and major depressive disorder in patients with metabolic syndrome(SPRINGER INDIA, 2015) Ari, Hatem; Kayrak, Mehmet; Gunduz, Mehmet; Kayhan, Fatih; Kaya, Zeynettin; Kiyici, Aysel; Uguz, FarukAssociations between metabolic syndrome (MS) and major depressive disorder (MDD) are well documented although the underlying biological mechanisms for this relationship are less studied. Paraoxonase (PON1) is a high-density lipoprotein (HDL)-associated enzyme, with demonstrated evidence of strong antioxidant activity. Oxidative stress has been implicated in the pathophysiology of MS and MDD. PON1 activity has been studied to some extent in patients with MS and less in MDD. The aim of this study was to compare serum PON1 activity in patients with MS and MDD, MS without MDD, and normal control groups in the context of the biological mechanism of the association between MS and MDD. In this case-control study, 67 patients with MS and 25 healthy controls from the hospital-university staff were recruited. All patients and healthy controls were assessed by a semi-structured psychiatric interview. Patients with MDD were diagnosed according to the DSM-IV criteria for MDD. Serum PON1 activity was determined with a spectrophotometric method, and the activity was compared between patients with MS and MDD, with MS but without MDD, and control groups. Serum PON1 activity levels were lower in patients with MS and MDD group compared to those in the patients with MS and without MDD group and control group (69.5+/-24.2, 84.3+/-34.6, and 97.1+/-40.8 U/ml, p=0.03, respectively). Post hoc analysis showed that PON1 activity was statically significantly lower in the MS with MDD group than in the control group (p=0.02). Impaired PON1 activity, in the context of enhanced oxidative stress, could be one of the possible underlying biological mechanisms of the MS-MDD association.Öğe Bir üniversite hastanesinde yatarak tedavi gören hastalarda depresyon ve anksiyete bozukluklarının yaygınlığı(Selçuk Üniversitesi Tıp Fakültesi, 2011) Kayhan, Fatih; Kucur, RahimBu çalışmada hastanede yatarak tedavi gören hastalarda depresyon ve anksiyete bozukluklarının yaygınlığını saptamayı, sosyodemografik faktörler, tıbbi hastalıklar ve uygulanan tedaviler arasındaki ilişkiyi ortaya koymayı amaçladık. Çalışmaya psikiyatri ve çocuk hastalıkları servisleri dışında yatarak tedavi gören 650 hasta basit rastgele örneklem yöntemiyle seçilerek dahil edildi. Dışlama kriterleri sonucunda 57 hasta çalışma dışı bırakıldı. Depresyon ve anksiyete bozukluklarının şiddetini değerlendirmek için HAM-D ve HAM-A ölçekleri kullanıldı. Depresyon ve anksiyete bozukluklarının tanılarını değerlendirmek için SCID-I/CV kullanıldı. Tüm örneklem ele alındığında, olguların %37,5'inde (s=226) bir psikiyatrik bozukluk, %14,3'ünde (s=86) bir duygudurum bozukluğu, %23,2'sinde (s=140) bir anksiyete bozukluğu, %2,3'ünde (s=14) alkol kullanım bozukluğu saptandı. Lojistik regresyon analizi sonuçlarımıza göre ise yatan hastalarda kadın cinsiyet ve geçirilmiş bireysel psikiyatrik öykü psikiyatrik bozukluk ile ilişkili bağımsız ilişkili etkenler olarak bulundu. Bulgularımız psikiyatrik bozuklukların hastanede yatarak tedavi gören ve kronik hastalığı olan bireylerde sağlıklı nüfusa göre daha sık olduğunu göstermektedir. Bireysel psikiyatrik bozukluk öyküsü olanlarda, kadınlarda depresyon ve anksiyete bozuklukları daha sık görülmekte ve hastalar için bir risk faktörü olarak görünmektedir. Psikiyatrik bozukluklar, yatan hastalarda sık görülmesine rağmen sağlık ekibi tarafından yeterince tanınamamakta ve tedavi edilemeğini düşündürmektedir. Erken dönemde tanınamayan ve tedavi edilmeyen psikiyatrik bozuklukların, hastaların hastanede yatış süresini uzattığı, sık hastane yatışlarına, sosyal ve maddi yönden kayıplara neden olduğu düşünülebilir.Öğe Clinical correlates of worsening in obsessive-compulsive symptoms during pregnancy(ELSEVIER SCIENCE INC, 2011) Uguz, Faruk; Kaya, Veli; Gezginc, Kazim; Kayhan, Fatih; Cicek, ErdincThis study examined clinical factors related to worsening of obsessive-compulsive disorder (OCD) in pregnant women. For comorbid diagnoses at the onset of pregnancy and frequency of several obsessive-compulsive symptoms, there was a significant difference between women whose OCD worsened during the pregnancy and those in whom the OCD did not worsen. Crown Copyright (C) 2011 Published by Elsevier Inc. All rights reserved.Öğe Delirium Following Acute Myocardial Infarction: Incidence, Clinical Profiles, and Predictors(Wiley-Blackwell Publishing, Inc, 2010) Uğuz, Faruk; Kayrak, Mehmet; Çiçek, Erdinç; Kayhan, Fatih; Arı, Hatem; Altunbaş, GökhanPURPOSE. To examine the incidence, clinical profile, and predictors of delirium following acute myocardial infarction (MI). DESIGN AND METHODS. The study sample included 212 consecutive patients with acute MI who were admitted to the coronary intensive care unit of a university hospital. FINDINGS. Delirium was found to occur in 5.7% of the patients. The predictors of delirium were advanced age, higher level of serum potassium at admission, and experience of cardiac arrest during MI. PRACTICE IMPLICATIONS. Delirium is reasonably prevalent in patients with acute MI. We propose that patients with the risk factors that have been delineated in this study should be evaluated carefully.Öğe Depressive Symptoms in Patients with Obstructive Sleep Apnea(BILIMSEL TIP PUBLISHING HOUSE, 2016) Karamanli, Harun; Kayhan, Fatih; Akgedik, RecepOBJECTIVES: Different studies have investigate depressive symptom degree within sleep disordered patients with obstructive sleep apnea (OSA). However, little is known and unclear about OSA in patients with depression symptom in the literature. The purpose of this study was to investigate patients with OSA would have a higher prevalence of depression symptom relative to control patients. MATERIAL AND METHODS: 72 patients with OSA (AHI >= 5) and 24 control subjects (AHI < 5) were assessed for depression symptom using the Beck Depression Inventory. Participants were underwent an overnight polysomnography assessment. An apnea-hypopnea index >= 5 events per hour was used as diagnosis for OSA. The associations between each total score on the Beck Depressive Inventory (BDI) and polysomnographic parameters were examined by correlation analysis. RESULTS: We demonstrated that BDI scores has statistically significant correlation with the OSA in our present study according to similar previous studies (p = .008). Oxygen Desaturation Index (ODI) has correlated with BDI (r = 0.31). CONCLUSION: These findings show that the frequency depression symptom is higher among individuals with OSA. Patients with OSA should be screened cautiously for depressive disorders.Öğe Electrophysiological assessment in patients with long term hypoxia(RIYADH ARMED FORCES HOSPITAL, 2016) Ilik, Faik; Pazarli, Ahmet C.; Kayhan, Fatih; Karamanh, Harun; Ozlece, Hatice K.Objective: To evaluate visual evoked potentials (VEP) patterns in chronic obstructive pulmonary disease (COPD) patients who were compliant with supplemental oxygen treatment relative to noncompliant COPD patients. Methods: This prospective study protocol was reviewed and approved by the local ethical committee of Selcuk University and the research was performed in the Department of Neurology, Elbistan State Hospital, Kahramanmaras, Turkey from May to October 2014. Blood gas measurements and pulmonary function tests were carried out in patients with advanced stage COPD. The VEP was assessed in both eyes in both compliant and non-compliant patients. Results: The study included 43 patients; 24 (55.8%) of the patients were not in compliance with their supplemental oxygen treatment, while 19 patients (44.2%) received adequate oxygen treatment. There was no statistically significant difference between patients with regards to pulmonary function test results and blood gas measurements. The VEP latency was significantly greater in both eyes of the noncompliant patients. Conclusion: Previous studies have reported prolonged VEP latencies in inflammatory diseases of the central nervous system. Similar electrophysiological findings were observed in our study and we propose that this may be due to oxidative stress, and inflammation that occurs secondary to chronic ischemia.Öğe Incidentally discovered colpocephaly and corpus callosum agenesis in asymptomatic adult patient(CUKUROVA UNIV, FAC MEDICINE, 2016) Buyukgol, Huseyin; Gunes, Muzaffer; Ilik, Faik; Kayhan, FatihThe corpus callosum is the biggest commissural structure located in two brain hemispheres and it ensures the connection between cortical and subcortical neurons. The agenesis of the corpus callosum is generally diagnosed in the prenatal period or childhood. It is observed along with congenital abnormalities such as mental and motor retardation, seizures, myelomeningocele. In this article, we reported a case of colpocephaly and corpus callosum agenesis with no symptoms that diagnosed incidentally.Öğe Is Pregnancy Associated with Mood and Anxiety Disorders? A Cross-Sectional Study(ELSEVIER SCIENCE INC, 2010) Uğuz, Faruk; Gezginç, Kazım; Kayhan, Fatih; Sarı, Serap; Büyüköz, DeryaObjective: To compare current prevalence of mood and anxiety disorders in pregnant and nonpregnant women. Method: The study sample included 309 pregnant women and 107 control subjects. Mood and anxiety disorders were determined by structured clinical interviews. Results: The rate of any mood or anxiety disorder was 19.4% in the pregnant women. Major depression (5.5%) and obsessive-compulsive disorder (5.2%) were the most common diagnoses in the pregnant women. There was no significant difference between pregnant and nonpregnant women with respect to the prevalence rate of mood and anxiety disorders. Conclusion: The results suggest that pregnancy is not a risk factor for the development of mood and anxiety disorders.Öğe Major Depression in Long-Term Oxygen Therapy Dependent Chronic Obstructive Pulmonary Disease(WILEY, 2018) Kayhan, Fatih; Ilik, Faik; Karamanli, Harun; Pazarli, Ahmet Cemal; Kayhan, AysegulPURPOSEWe aimed to investigate the frequency of major depression (MD) in long-term oxygen therapy (LTOT) dependent chronic obstructive pulmonary disease (COPD) patients and the effect of depression on patients' compliance with the treatment. DESIGN AND METHODSFifty-four consecutive patients were enrolled in the study and diagnosed as stage 4 COPD according to Global Initiative for Chronic Obstructive Lung Disease guideline. MD was diagnosed with the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition/Clinical Version. FINDINGSThirty-four (63.0%) patients had MD. MD frequency was significantly higher in patients who were noncompliant with LTOT compared with compliant patients. PRACTICE IMPLICATIONSMD is a common psychiatric disorder in COPD patients receiving LTOT.Öğe Mood and anxiety disorders in patients with abnormal uterine bleeding(ELSEVIER SCIENCE BV, 2016) Kayhan, Fatih; Alptekin, Husnu; Kayhan, AysegulObjective: We aimed to investigate the prevalence of mood and anxiety disorders in patients with abnormal uterine bleeding (AUB) and the relationship between mood and anxiety disorders and AUB. Method: 96 consecutive patients with not yet classified AUB based on the PALM-COEIN classification and 94 volunteers were included in the study. Mood and anxiety disorders were ascertained by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition/Clinical Version. Results: Out of 96 patients, 55 (57.3%) met the criteria for at least one diagnosis of mood and anxiety disorder. The most common psychiatric disorders in patients with AUB were major depression (n = 15, 15.6%), generalized anxiety disorder (n = 18, 18.8%) and obsessive compulsive disorder (n = 22, 22.9%), respectively. Compared with the control group, the prevalence of any psychiatric disorder (x(2) = 43.52, p = 0.000), any mood disorder (x(2) = 10:37, p = 0.001) and any anxiety disorder (Fisher's exact test, p = 0.000) was higher in patients with AUB. The presence of any mood and anxiety disorder was an independent risk factor for AUB. Conclusion: Mood and anxiety disorders, particularly major depression, generalized anxiety disorder and obsessive-compulsive disorder were frequently observed in patients with AUB. (C) 2016 Elsevier Ireland Ltd. All rights reserved.Öğe Mood and anxiety disorders in patients with chronic low back and neck pain caused by disc herniation(TAYLOR & FRANCIS LTD, 2016) Kayhan, Fatih; Gezer, Ilknur Albayrak; Kayhan, Aysegul; Kitis, Serkan; Golen, MustafaObjective: We investigated the prevalence of mood and anxiety disorders in patients with chronic low back and neck pain caused by disc herniation and the relationships between pain and mood, and anxiety disorders.Methods: In total, 149 patients with disc herniation and 60 healthy subjects were included. Disc herniation was diagnosed based on a physical examination and magnetic resonance imaging. Mood and anxiety disorders were diagnosed using the Structured Clinical Interview of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition/Clinical Version.Results: The mean age of the study subjects (n=209) was 45.9611.45 years. Seventy (46.6%) patients with disc herniation met the criteria for at least one mood or anxiety disorder. The prevalence rates of mood and anxiety disorders were 16.6% and 35.8%, respectively. The most common specific diagnoses were major depression (n=25, 16.9%) and generalised anxiety disorder (n=19, 12.8%).Conclusions: Mood and anxiety disorders were more commonly seen in patients with lumbar or cervical disc herniation than in those without herniation. No relationship was detected between pain severity and mood or anxiety disorders. However, mood and anxiety disorders were associated with neurological deficits.Öğe Pregnancy-Onset Panic Disorder: Incidence, Comorbidity and Associated Factors(AVES, 2015) Guler, Ozkan; Kaya, Veli; Gezginc, Kazim; Kayhan, Fatih; Cicek, Erdin; Sonmez, Onder; Uguz, FarukIntroduction: The present study aimed to investigate the incidence rate of pregnancy-onset panic disorder (POPD) among Turkish pregnant women using a diagnostic interview. Additionally, we examined whether the independent socio-demographic or clinical risk factors were associated with the risk of panic disorder in these women. Methods: The study sample comprised 1475 consecutive pregnant women who presented to the obstetric outpatient clinics of two research centers. The rate of POPD in these participants was 1.3% (Group 1, n= 20). The 20 women with POPD were compared with 250 pregnant women without pregnancy-onset depression or anxiety (Group 2; controls). Panic disorder and other anxiety or mood disorders were determined by means of the Structured Clinical Interview for DSM-IV. Comorbid Axis II disorders were diagnosed with the Structured Clinical Interview for DSM-III-R Personality Disorders. Results: The incidence rate of panic disorder was 1.3% (n= 20). In group 1, 55% (n= 11) of the women with POPD had an additional mood or anxiety disorder. In addition, the prevalence rate of any cluster C personality disorder, including avoidant, passive-aggressive and obsessivecompulsive personality disorders, were significantly greater in the group 1 women with POPD than the control pregnant women without a panic disorder (group 2). Conclusion: The women with POPD were more likely than the controls to have a cluster C Axis II disorder and a history of a pre-existing anxiety or mood disorder.Öğe Prevalence of personality disorders in patients with chronic migraine(W B SAUNDERS CO-ELSEVIER INC, 2016) Kayhan, Fatih; Ilik, FaikBackground: The present study aimed to investigate the prevalence of personality disorders (PDs) in patients with chronic migraine (CM). Methods: This study included 105 CM patients who were diagnosed according to the criteria of the International Headache Society (IHS) and 100 healthy volunteers. PDs were diagnosed with the Structured Clinical Interview for DSM, Revised Third Edition Personality Disorders, and pain severity and level of disability were assessed with the Migraine Disability Assessment (MIDAS) test. Results: Of the 105 CM patients, 85 (81%) had at least one PD. PDs were more prevalent in the patient group than in the healthy control group, and the most common PDs were obsessive-compulsive (n = 53, 50.5%), dependent (n = 20, 19%), avoidant (n = 20, 19%), and passive-aggressive (n = 14, 13.3%) PDs. The MIDAS scores of the CM patients with PDs were higher than those of the CM patients without PDs. Conclusion: PDs, particularly obsessive-compulsive, dependent, avoidant, and passive-aggressive PDs, were frequently observed in CM patients in the present study. (C) 2016 Elsevier Inc. All rights reserved.Öğe Relationships of neutrophil-lymphocyte and platelet-lymphocyte ratios with the severity of major depression(ELSEVIER IRELAND LTD, 2017) Kayhan, Fatih; Gunduz, S. Sule; Ersoy, Sevde Afife; Kandeger, Ali; Annagur, Bilge BurcakWe aimed to evaluate the neutrophil-lymphocyte (NLR) and platelet-lymphocyte (PLR) ratios of inpatients and outpatients suffering from different levels of major depression. In total, 100 inpatients and 60 patients treated at an outpatient clinic were included the study. The presence of mood and anxiety disorders was identified with the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition/ Clinical Version, and the Hamilton Depression Rating Scale was used to assess the severity of major depression (MD). Inpatients and outpatients with MD did not differ in NLR or PLR. The PLRs of patients who had severe major depression with psychotic features were higher than those of patients with other types of depression, but no differences in NLRs were detected across types of depression. The PLRs were higher in patients with severe levels of major depression with psychotic features than in other patients. This parameter may be more predictive than is NLR for assessing the prognosis of major depression.Öğe Sexual dysfunction, mood, anxiety, and personality disorders in female patients with fibromyalgia(DOVE MEDICAL PRESS LTD, 2016) Kayhan, Fatih; Kucuk, Adem; Satan, Yilmaz; Ilgun, Erdem; Arslan, Sevket; Ilik, FaikBackground: We aimed to investigate the current prevalence of sexual dysfunction (SD), mood, anxiety, and personality disorders in female patients with fibromyalgia (FM). Methods: This case-control study involved 96 patients with FM and 94 healthy women. The SD diagnosis was based on a psychiatric interview in accordance with the Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria. Mood and anxiety disorders were diagnosed using the Structured Clinical Interview. Personality disorders were diagnosed according to the Structured Clinical Interview for DSM, Revised Third Edition Personality Disorders. Results: Fifty of the 96 patients (52.1%) suffered from SD. The most common SD was lack of sexual desire (n=36, 37.5%) and arousal disorder (n=10, 10.4%). Of the 96 patients, 45 (46.9%) had a mood or anxiety disorder and 13 (13.5%) had a personality disorder. The most common mood, anxiety, and personality disorders were major depression (26%), generalized anxiety disorder (8.3%), and histrionic personality disorder (10.4%). Conclusion: SD, mood, and anxiety disorders are frequently observed in female patients with FM. Pain plays a greater role in the development of SD in female patients with FM.