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Öğe Assessment of capsular block syndrome with Scheimpflug camera(CANADIAN OPHTHAL SOC, 2009) Kamis, Umit; Ozturk, Banu Turgut; Sahin, Alparslan; Kerimoglu, Hurkan; Okudan, Suleyman[Abstract not Available]Öğe Association of an Endothelial Nitric Oxide Synthase Gene Polymorphism with Diabetic Retinopathy(KAMLA-RAJ ENTERPRISES, 2018) Inan, Sibel; Zengin, Nazmi; Ozturk, Banu Turgut; Kerimoglu, Hurkan; Unlu, Ali; Dogan, IsmetThe association of the endothelial nitric oxide synthase (eNOS) G894T gene polymorphism with the severity of diabetic retinopathy (DRP) and macular edema (DME) was investigated. One hundred-seven patients with type-2 diabetes mellitus were included. Forty-five patients served as a control group. eNOS G894T gene polymorphism was analysed by polymerase chain reaction. The mean age was 55.8 +/- 9.4 years in the study group and 51.8 +/- 9.7 years in the control group. There was no significant difference in the genotypes between the diabetic and the control group, or between the non-DRP group and the DRP group. The frequency of the G allele was higher in the proliferative DRP group than that in the non-proliferative DRP group. The GG genotype of G894T gene polymorphism was associated with macular edema and hyperglycaemia. The eNOS G894T gene polymorphism seems to be associated with the DME and unregulated hyperglycaemia.Öğe Bilateral Optic Pit Maculopathy: Case Report(ORTADOGU AD PRES & PUBL CO, 2011) Oltulu, Refik; Sahin, Alparslan; Kerimoglu, HurkanIn this paper, we present an unusual case of bilateral optic pit maculopathy. Optic disc pits occur in less than 1 in 10000 and are bilateral in 10% to 15% of cases. Approximately 50% of cases with congenital optic disc pits are associated with serous macular detachment. Long-standing serous detachments are usually associated with cystic degeneration of macula and pigment loss from the underlying retinal pigment epithelium. Hence, most eyes with serous macular detachment associated with an optic disc pit have a relatively poor visual prognosis. Here, we emphasized the clinical importance of assessment of bilateral optic disc pit.Öğe Comparison of Intravitreal Bevacizumab and Ranibizumab Treatment for Diabetic Macular Edema(MARY ANN LIEBERT, INC, 2011) Ozturk, Banu Turgut; Kerimoglu, Hurkan; Bozkurt, Banu; Okudan, SuleymanAim: The aim of this study was to compare the effects of bevacizumab and ranibizumab on visual function and macular thickness in patients with diabetic macular edema (DME). Methods: The data of diabetic patients who had been treated with bevacizumab for DME were reviewed. Those patients who received 1 injection of intravitreal bevacizumab and ranibizumab with at least 6-month interval were considered for enrollment. The best-corrected visual acuity (BCVA) assesment with Early Treatment Diabetic Retinopathy Study (ETDRS) chart and central subfield macular thickness (CSMT) measurement using optical coherence tomography-3 before and after the injections were recorded as outcome measures. Results: The study included 29 eyes of 29 patients with a mean age of 56.18 +/- 3.07 years. The median BCVA was 59 ETDRS letters and the median CSMT was 411 mu m preceeding the bevacizumab injection. At the 4th-6th week control after the injection, median BCVA increased to 61.50 ETDRS letters and the median CSMT decreased to 373 mu m. This change in BCVA and CSMT was found to be statistically significant (P = 0.029 and P = 0.011, respectively). The mean interval between bevacizumab and ranibizumab treatment was 9.54 +/- 2.64 months. Ranibizumab treatment increased the median BCVA from 53 to 66 ETDRS letters and decreased the median CSMT from 428 mu m to a level of 279 mu m, which were statistically significant (P < 0.001 and P < 0.001, respectively). The median change in BCVA was 4.5 ETDRS letters in the bevacizumab group and 6 ETDRS letters in the ranibizumab group (P = 0.58), whereas the median changes in CSMT were 41 and 100 mu m after bevacizumab and ranibizumab injections, respectively (P = 0.005). Conclusions: Bevacizumab and ranibizumab are both effective antivascular endothelial growth factor drugs preferred in the treatment of DME. Our comparison of both therapies on the same patients suggested that the effect on BCVA was not statistically different, but ranibizumab provided more decrease in CSMT.Öğe Diurnal Variation of Anterior Chamber Flare(TURKISH OPHTHALMOLOGICAL SOC, 2015) Adam, Mehmet; Okka, Mehmet; Ozturk, Banu Turgut; Bozkurt, Banu; Kerimoglu, Hurkan; Pekel, Hamiyet; Okudan, SuleymanObjectives: To investigate the ideal time and reproducibility of anterior chamber flare measurements. Materials and Met-hods: Anterior chamber flare measurements were performed with laser flaremetre device at 8 am to 45 volunteers and these measurements were repeated on the same day at 12 pm and 4 pm. Results: Twenty- five (55.5%) of the volunteers were women and 20 (44.5%) were men; mean age was 28.67 +/- 7.40 (18- 49) years. The mean anterior chamber flare measurements taken following the ophthalmologic examination were 5.94 +/- 1.41 foton/msn at 8 am, 5.65 +/- 1.45 foton/msn at 12 pm, and 5.79 +/- 1.20 foton/msn at 4 pm. No statistical difference was found between the measurements (p=0.08). Subgroup analysis according to eye color, revealed no significant difference between flare measurements in brown, hazel, and green eyes (p=0.21). Correlation analysis demonstrated association between age and all flare measurements within the day (r=0.24, p=0.03; r=0.41, p=0.01, r=0.27, p=0.01). Conclusion: No significant diurnal change was detected in the flare measurements of our study subjects but positive correlation with age was observed. Hence, all flare measurements within a day are reliable and have high repeatability in healthy subjects.Öğe Does lens status affect the course of early intraocular pressure and anterior chamber changes after intravitreal injection?(WILEY-BLACKWELL, 2011) Kerimoglu, Hurkan; Ozturk, Banu T.; Bozkurt, Banu; Okka, Mehmet; Okudan, SuleymanPurpose: This study aimed to observe changes in anterior chamber parameters and the course of intraocular pressure (IOP) after injection of 0.1 ml intravitreal triamcinolone acetonide (TA) and to determine differences between phakic and pseudophakic eyes without vitreous reflux. Methods: A prospective observational clinical trial was conducted with 89 patients who received an intravitreal injection of TA and did not display vitreous reflux. Intraocular pressure measurements were made before injection and at 3, 10, 20, 30 and 40 mins after injection. Pentacam measurements were made before injection and at 5, 15, 30 and 45 mins after injection. Results: Anterior chamber depth (ACD) and anterior chamber volume (ACV) were significantly greater in pseudophakic eyes than in phakic eyes at all measurement time-points (p < 0.001). There was a decrease in both ACD and ACV at 5 mins after injection, and a gradual increase to normal values was observed at 15, 30 and 45 mins after injection in all study eyes. Compared with pre-injection measurements, changes in ACD and ACV were statistically significant at each time-point in both phakic and pseudophakic eyes (p < 0.001). A significant increase in IOP within 3 mins of injection was observed in both groups and a more rapid decrease 10 mins after injection was observed in pseudophakic eyes. The differences in IOP between phakic and pseudophakic eyes at all measurement time-points, except baseline and 3 mins after injection, were statistically significant (p < 0.001). Intraocular pressure < 30 mmHg and < 24 mmHg was recorded in all pseudophakic eyes at 10 and 20 mins after intravitreal injection, respectively. Conclusions: Following intravitreal injection of 0.1 ml TA, without vitreous reflux, IOP decreased to safe levels more quickly in pseudophakic eyes than in phakic eyes. Although there were more pronounced changes in anterior chamber parameters in pseudophakic eyes, these changes were reversible without any residual clinical significance.Öğe Effect of serum cytokines and VEGF levels on diabetic retinopathy and macular thickness(MOLECULAR VISION, 2009) Ozturk, Banu Turgut; Bozkurt, Banu; Kerimoglu, Hurkan; Okka, Mehmet; Kamis, Umit; Gunduz, KemalPurpose: To investigate the role of serum inflammatory cytokines and vascular endothelial growth factor (VEGF) in diabetic retinopathy (DR) and evaluate their relationship with macular thickness measurements obtained with optical coherence tomography (OCT). Methods: The study enrolled 28 healthy subjects (Group 1), 31 patients without DR (Group 2), 49 patients with nonproliferative DR (Group 3), and 46 patients with proliferative DR (Group 4). Macular profile was assessed with Stratus OCT-3 and the serum concentrations of VEGF and interleukin-1 alpha (IL-1 alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), macrophage inflammatory protein (MIP-1 alpha), monocyte chemoattractant protein (MCP-1), and epidermal growth factor (EGF) were measured using multiplex bead immunoassay. Results: The median value of the visual acuity was 20/20 (Groups 1 and 2), and 20/100 (Group 3), and 20/125 (Group 4). The median value of central subfield macular thickness was estimated as 165.50 mu m in Group 1, 202.5 mu m in Group 2, 318 mu m in Group 3, and 310 mu m in Group 4. The median serum VEGF level, which was 98.20 pg/ml in Group 1, demonstrated a progressive rise to 125.37 pg/ml in Group 2, to 153.07 pg/ml in Group 3, and to 149.12 pg/ml in Group 4. Statistical significance was found between all groups (p<0.05) except between Groups 3 and 4 (p=0.87). The median levels of IL-1 alpha and IL-6 were zero in all groups. The median serum levels of IL-8, IL-10, MIP-1 alpha, and EGF revealed a wide range within each group but no statistical significance between the groups (p>0.05). The median serum levels of IL-8, IL-10, MIP-1 alpha, and EGF revealed a wide range within each group, however, no statistically significant relationship was found between the groups (p>0.05). The median values of the serum MCP-1 concentrations presented a statistically significant rise with the progression of DR (p=0.02). No correlation was found between macular thickness and serum cytokine and VEGF levels (p>0.05). Conclusions: Increased serum levels of VEGF and MCP-1 may act as a key regulator of DR and provide a potential tool for risk assessment in diabetic patients. Further studies that evaluate both vitreous and serum levels in various stages of DR are needed to provide a better understanding of the interaction between systemic and local inflammatory and angiogenic factors.Öğe The Evaluation of Retinal Nerve Fiber Layer Thickness in Patients with Obstructive Sleep Apnea Syndrome(HINDAWI PUBLISHING CORPORATION, 2013) Adam, Mehmet; Okka, Mehmet; Yosunkaya, Sebnem; Bozkurt, Banu; Kerimoglu, Hurkan; Turan, MeydanAim. To evaluate the retinal nerve fiber layer (RNFL) thickness in patients with obstructive sleep apnea syndrome (OSAS) by optical coherence tomography (OCT). Materials and Method. We studied 43 new diagnosed OSAS patients and 40 healthy volunteers. Patients underwent an overnight sleep study in an effort to diagnose and determine the severity of OSAS. RNFL analyses were performed using Stratus OCT. The average and the four-quadrant RNFL thickness were evaluated. Results. There was no difference between the average and the four-quadrant RNFL thickness in OSAS and control groups. There was no correlation between apnea-hypopnea index and intraocular pressure. Body mass index of patients with moderate and severe OSAS was significantly higher in patients with mild OSAS. Conclusion. Mean RNFL thickness did not differ between the healthy and the OSAS subjects, however, the parameters were more variable, with a larger range in OSAS patients compared to controls.Öğe Evaluation of Retinal Nerve Fiber Layer Thickness with Optical Coherence Tomography in Type 1 Diabetes Mellitus Patients(ORTADOGU AD PRES & PUBL CO, 2011) Gonul, Saban; Ozkagnici, Ahmet; Ozturk, Banu Turgut; Kerimoglu, Hurkan; Sahin, AlparslanObjective: To evaluate retinal nerve fiber layer (RNFL) thickness changes of type 1 diabetes mellitus (DM) patients with and without diabetic retinopathy (DR). Material and Methods: One hundred-eighteen patients with type 1 DM and 49 age-matched control subjects were enrolled in the study. Ninety eight of 118 diabetic patients with DR were assigned as group 1 and the remaining 20 patients without DR were labeled as group 20 (n = 98). The RNFL thickness of all subjects were measured using optical coherence tomography (OCT). Results: The study included 118 type 1 DM patients with a mean age of 18.77 +/- 8.80 years. The mean age of 49 subjects in the control group was 18.71 +/- 5.72 (range 7-40) years. The mean RNFL thickness was 103.79 +/- 6.45 mu m in the control group, 100.00 +/- 11.93 mu m in group 1 and 85.59 +/- 19.81 mu m in group 2. The decrease in group 2 was found statistically significant (p < 0.001). The mean RNFL thickness in the superior, nasal, inferior and temporal quadrants were less in group 1 compared to controls, however this data was not statistically significant (p = 0.274, p = 0.149, p = 0326, p = 0783, respectively). In group 2, the RNFL thickness revealed a statistically significant decrease in all quadrants (p < 0.001) except temporal quadrant (p = 0.396). The mean duration of DM was significantly longer in group 2 (153.80 +/- 70.35) compared to group 1(60.76 +/- 50.41 months) (p < 0.001). However, there was no correlation between the RNFL thickness and the duration of DM. Conclusion: The RNFL thickness of patients with type 1 DM was found less compared to control subjects. This was more prominent in patients with established retinopathy (group 2). These findings suggested that the RNFL thickness measurement with the aid of OCT may be used as an adjunctive diagnostic tool for early diagnosis of DR.Öğe Glucose regulation influences treatment outcome in ranibizumab treatment for diabetic macular edema(ELSEVIER SCIENCE INC, 2011) Ozturk, Banu Turgut; Kerimoglu, Hurkan; Adam, Mehmet; Gunduz, Kemal; Okudan, SuleymanPurpose: To evaluate the effect of glucose regulation on intravitreal ranibizumab injection for clinically significant diabetic macular edema (DME). Methods: This retrospective study enrolled 65 eyes of 65 patients with persistent DME treated with intravitreal ranibizumab injection. The main outcome measures were the change in best corrected visual acuity (BCVA), the central subfield macular thickness (CSMT) recorded with optical coherence tomography (OCT), and its correlation with the serum hemoglobin A(1c) values (HbA(1c)). Results: The study included 24 (36.9%) female and 41(63.1%) male patients with a mean age of 58.90 +/- 9.45 years. The mean HbA(1c) of the enrolled patients was 8.25 +/- 1.74% (range 5.7-12.7%). The median value of BCVA at baseline examination was 20/80 (52 letters), and the median CSMT was 468 pm (range 255-964 mu m). In the final control after 4-6 weeks following injection, the median value of BCVA increased to 20/50 (59.50 letters) and the median CSMT decreased to 310 pin (range 129-652 mu m). This change in BCVA and macular thickness was found to be significant (P<.001 for both). There was no correlation between BCVA and the change in macular thickness (coefficient=0.04, P=.78). The serum HbA(1c) values were found to be negatively correlated with the change in CSMT (coefficient=-0.50, P<.001). Conclusions: The results of intravitreal ranibizumab injection for DME demonstrated a beneficial effect on visual acuity and a decrease in CSMT which is inversely correlated with the serum HbA(1c), level. (C) 2011 Elsevier Inc. All rights reserved.Öğe Linear corneal epithelial keratitis with a horseshoe pattern(TAYLOR & FRANCIS INC, 2007) Erdem, Uzeyir; Hurmeric, Volkan; Muftuoglu, Orkun; Kerimoglu, HurkanPurpose: To report the treatment and follow-up of a linear epithelial keratitis with a horseshoe pattern. Methods: A 21-year-old Turkish soldier, who presented with epithelial keratitis with a horseshoe pattern that did not respond to immunosuppressive and multiple anti-microbial treatment, was studied clinically. Results: No microorganism was identified with different stains, cultures, and herpes simplex virus-polymerase chain reaction. The impression cytology revealed prominent polymorphonuclear leukocyte infiltration at the keratitis line. The keratitis did not respond to different antimicrobial treatment or local and systemic corticosteroids. After a fourth scraping was performed deeply with a disc-knife, the lesion healed and did not recur in six months. Conclusion: Linear epitheliitis of cornea with a horseshoe pattern was not found to be associated with any microorganism or systemic disease.Öğe Ocular Changes Associated with Topiramate(TAYLOR & FRANCIS INC, 2011) Ozturk, Banu Turgut; Genc, Emine; Tokgoz, Mine; Kerimoglu, Hurkan; Genc, Bulent OguzPurpose: To determine the changes in refractive error, and the cornea, anterior chamber, and retina induced by topiramate. Methods: The study included 76 eyes of 38 patients that began to use topiramate due to migraine. Following ophthalmological examination, all of the patients underwent central corneal thickness (CCT), anterior chamber volume (ACV), anterior chamber depth (ACD), and anterior chamber angle (ACA) measurement using a Scheimpflug camera, as well as macular thickness, retinal and retinal nerve fiber layer thickness (RNFLT) measurements using optical coherence tomography (OCT). These procedures were repeated 15, 30, and 90 days after the initiation of topiramate therapy. Results: The median refractive error value showed a statistically significant increase from -0.25 diopters (D) to -0.62 D at the 90th day follow-up (P < 0.001). Mean CCT was 570.56 mu m before treatment and increased to 573.69 mu m at the 15th day follow-up, 575.31 mu m at the 30th day follow-up, and 574.56 mu m at the 90th day follow-up; however, these changes were not statistically significant. Mean ACV, ACD, and ACA did not exhibit statistically significant changes. Mean retinal thickness (RT) increased during the treatment from 263.46 mu m to 271.60 mu m, which was not statistically significant. The initial mean RNFLT was 100.56 +/- 15.36 mu m and significantly increased to 110.2 +/- 8.41 mu m and 111.03 +/- 14.59 mu m at the 30th and 90th day follow-ups, respectively (P = 0.01 and P = 0.004, respectively). Conclusions: During the 3-month follow-up of patients using topiramate 50 mg d(-1) significant myopic shift and an increase in RNFLT were observed. Further studies are warranted in order to assess the effects of topiramate when used long term and at higher doses.Öğe Topiramate-induced acute-onset myopia and central corneal thickening: Pentacam Scheimpflug imaging findings(CANADIAN OPHTHAL SOC, 2009) Kerimoglu, Hurkan; Tokgoz, Mine; Ozturk, Banu; Gonul, Saban; Pekel, Hamiyet[Abstract not Available]Öğe Unilateral chemosis, acute onset myopia and choroidal detachment following the use of tamsulosin(WILEY-BLACKWELL PUBLISHING, INC, 2010) Kerimoglu, Hurkan; Zengin, Nazmi; Ozturk, Banu; Gunduz, Kemal[Abstract not Available]
