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Öğe Anti-Mullerian hormone is associated with extrauterine involvement and stage of disease in patients with endometrial cancer(INFORMA HEALTHCARE, 2015) Dogan, N. U.; Kerimoglu, O. S.; Karabagli, P.; Pekin, A.; Yilmaz, S. A.; Incesu, F.; Celik, C.Our aim was to evaluate serum levels of anti-Mullerian hormone (AMH) and also immunohistochemical (IHC) staining properties of AMH receptor type II (AMHRII) in patients with endometrial cancer (EC) and a control group. Preoperatively, serum levels of AMH were assessed and AMHRII expression was evaluated by immunohistochemistry in a benign and malignant group. AMH serum levels of the control group and EC patients were comparable. For EC patients, there was no difference with respect to the AMH levels and tumour stage; grade; histological type; deep myometrial invasion; lymphovascular space invasion or lymph node involvement. However, AMH levels in patients with extrauterine involvement were higher than patients with disease confined to the uterus. EC samples were more likely to be stained positive for AMHRII than benign lesions. Also, as the stage of the lesion worsens, the rate of IHC staining of AMHRII decreases. In conclusion, AMHRII is expressed in normal endometrial cells as well as endometrial cancer cells. AMH levels increase in EC, with extrauterine involvement at least in locally advanced disease. Also AMH expression decreases as the disease is staged-up.Öğe ASSOCIATION OF ANTI-MULLERIAN HORMON (AMH) SERUM LEVELS AND ENDOMETRIAL AMH RECEPTOR II EXPRESSION IN PATIENTS WITH ENDOMETRIAL CANCER(LIPPINCOTT WILLIAMS & WILKINS, 2013) Celik, C.; Dogan, N. U.; Karabagli, P.; Kerimoglu, O. S.; Tazegul, A.; Incesu, F.[Abstract not Available]Öğe Association of clinical androgen excess with radial artery intima media thickness in women with polycystic ovary syndrome(TAYLOR & FRANCIS LTD, 2015) Yilmaz, S. A.; Kebapcilar, A.; Koplay, M.; Kerimoglu, O. S.; Pekin, A. T.; Gencoglu, B.; Dogan, N. U.This study explores the relationship between clinical cardiovascular risk factors and clinical androgen excess, with direct comparison to radial artery intima media thickness (rIMT). rIMT of 91 patients with polycystic ovary syndrome (PCOS) were compared with 72 healthy women. Patients were divided into three groups with regard to body mass index (BMI). Group1=56 women (31 controls and 25 PCOS) with low BMI(18-22.49 kg/m(2)), Group2=36 women (15 controls and 21 PCOS) with normal BMI (22.5-24.99 kg/m(2)) and Group3=71 women (26 controls and 45 PCOS) with high BMI (25-30 kg/m(2)). rIMT was significantly higher in patients with PCOS (p=0.007). rIMT was significantly higher group1 and group3 in patients with PCOS compared to controls (p=0.007 and p=0.042, respectively). There was a significant positive association between rIMT levels and fT in women with PCOS in group1 (r=0.24, p=0.04). rIMT levels correlated to fT levels in women with PCOS in group3 (r=0.32, p=0.03). Modified Ferriman-Gallwey (mFG) scores demonstrated a positive association with free testosterone, total testosterone, free androgen index, waist circumference (WC), LH levels, insulin levels, Homeostasis Model Assessment index(HOMA-IR), rIMT and a negative correlation with sex hormone binding globulin in group1 and group2. mFG scores demonstrated a positive association with free testosterone (r=0.33, p=0.029) in group3, but no association was found between mFG and WC, HOMA-IR in group3. Our findings indicate that clinical androgen excess may be associated with cardiovascular disease in patients with PCOS.Öğe Effect of drainage on postoperative pain after laparoscopic ovarian cystectomy(INFORMA HEALTHCARE, 2015) Kerimoglu, O. S.; Yilmaz, S. A.; Pekin, A.; Incesu, F.; Dogan, N. U.; Ilhan, T. T.; Celik, C.The aim of this prospective study was to investigate the effect of drainage on postoperative shoulder and abdominal pain after uncomplicated laparoscopic ovarian cystectomy (LOC). Allocation to drain or not to drain was non-randomised. There were 55 patients with drainage and 56 patients without drainage. Postoperative shoulder and abdominal pain was assessed using a 10-point visual analogue scale. Postoperative hospital stay in the drainage group was longer than the non-drainage group (p = 0.040). Postoperative shoulder pain scores at 6 h and 24 h were similar between the drainage and non-drainage groups (p = 0.376 and p = 0.847, respectively). Postoperative abdominal pain was higher in the drainage group at 6 h (p = 0.009), but was similar at 24 h (p = 0.097) between the groups. These data suggest that for LOC, drainage may not be useful to prevent postoperative shoulder pain and also increases postoperative abdominal pain and length of hospital stay.Öğe Effect of the FSH receptor polymorphism on the age at menarche(7847050 CANADA INC, 2019) Kerimoglu, O. S.; Pekin, A.; Yilmaz, S. A.; Incesu, F. N.; Nergiz, S.; Dogan, N. U.; Acar, H.Estrogen and estrogen receptor (ER) genes have an effect on the age at menarche. Follicle stimulating hormone (BID is an important hormone that plays a major role in the regulation of folliculogenesis and estrogen synthesis. The aim of this study was to investigate the influence of the FSH receptor (FSHR) polymorphisms Asn680Ser and Thr307Ala on age at menarche. Materials and Methods: FSH receptor gene polymorphisms were investigated in women who were admitted to Selcuk University between May 2013 and November 2014. Information about age at menarche was obtained through interviews. Polymorphic analysis of the FSH receptor gene was performed in 209 healthy female patients who had undergone an annual health examination. Genomic DNA was obtained from peripheral blood leukocytes, and polymorphisms were investigated using restriction fragment length polymorphism analysis. Results: The mean age at menarche was 12.95 +/- 1.62 years. The overall frequencies for Asn680Ser variants NN, NS, and SS were 40.2%, 36.4%, and 23.4%, respectively, whereas Thr307Ala variants TT, TA, and AA were 34.4%, 41.1%, and 24.4%, respectively. Menarche occurred 3.6 months earlier in subjects with TN homozygote genotype than in AS homozygotes, and the mean age at menarche was 2.5 months earlier in TN homozygotes compared with that in all other study subjects, but the differences were not statistically significant (p = 0.966 and p = 0.986, respectively). Conclusions: The Ala307Thr and Ser680Asn polymorphisms of the FSHR gene are not associated with age at menarche.Öğe Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome(ELSEVIER SCIENCE BV, 2014) Yilmaz, S. A.; Kerimoglu, O. S.; Pekin, A. T.; Incesu, F.; Dogan, N. U.; Celik, C.; Unlu, A.Objective: The aim of the present study was to evaluate serum concentrations of metastin in relation with hormonal and metabolic profile in patients with and without polycystic ovary syndrome (PCOS). Study design: The study was a clinical study. Eighty-three women with PCOS and 66 body mass index (BMI) matched controls were divided into two groups, based on BMI: overweight and obese (BMI >= 25 kg/m(2)) and normal weight. (BMI < 25 kg/m(2)) Hirsutism scores, hormonal and metabolic profile as well as metastin levels were evaluated in each subject. Blood samples were collected in the early follicular phase (between day 2 and day 5 of the menstrual cycle) at 9:00 AM, after an overnight fast. Circulating levels of LH, FSH, PRL, TSH, T, fT, DHEAS, 17-OH-P, sex hormone-binding globulin (SHBG), insulin, glucose, lipid profile and metastin were measured. Results: Metastin levels were significantly higher in the PCOS group compared to controls (2.02 ng/ml versus 1.16 ng/ml, p < 0.001). Metastin levels correlated significantly positively with luteinizing hormone (LH), total testosterone (T), dehydroepiandrosteronesulphate (DHEA-SO4) levels, modified Ferriman-Gallwey (mFG) scores and free androgen index (FAI); however, correlated negatively with sex hormone binding globulin (SHBG) levels (p < 0.05). When overweight or obese (BMI >= 25 kg/m(2)) and normal weight (BMI < 25 kg/m(2)) women with PCOS were compared to body mass index (BMI) matched controls, higher metastin levels were also found in PCOS groups (1.94 ng/ml versus 1.18 ng/ml, and 2.06 ng/ml versus 1.08 ng/ml, p < 0.05, respectively). Conclusions: These findings suggest that metastin levels were higher in women with PCOS as compared to controls regardless of BMI. Furthermore, metastin levels can be used as a specific marker for androgenic profile and this marker might play a role in the pathogenesis of PCOS. (C) 2014 Elsevier Ireland Ltd. All rights reserved.Öğe Pyometra in elderly post-menopausal women: a sign of malignity(I R O G CANADA, INC, 2015) Kerimoglu, O. S.; Pekin, A.; Yilmaz, S. A.; Bakbak, B. B. Gencoglu; Celik, C.Purpose: To describe the clinical and histopathological characteristics of 12 patients with pyometra and highlight the increased incidence of gynecological malignancy in these patients. Materials and Methods: The authors examined the medical records of 12 patients with pyometra, who were treated between 2009 and 2013. Results: All patients were post-menopausal, and their mean age was 70.83 6.978 years (min=61, max=82). To remove purulent fluid via dilation and because of the probability of malignancy, three patients (25%) underwent cervical biopsy and endometrial curettage; the other nine patients (75%) underwent curettage alone, with suitable antibiotic therapy. Of the 12 patients, nine (75%) had gynecologic malignancy [(endometrial cancer, n=5, 41.6%), (cervical cancer, n=3, 25%), (uterine leiomyosarcoma, n=1, 8.3%)]. In three (25%) patients, the cause of pyometra was benign pathologies, among which the most common were leiomyomas (n=2, 66.6%). Conclusion: Pyometra diagnosed during the post-menopausal period should be considered a complication caused by gynecological malignancy until proven otherwise.
