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Öğe Yalın Camsı Karbon Elektrot Kullanarak Farmasötik Formulasyon ve İnsan İdrarından Kortizolün Hızlı Kare Dalga Voltametrik Analizi(Selçuk Üniversitesi, 2019) Keskin, ErtuğrulA simple, fast and sensitive electrochemical method for the direct determination of cortisol in commercial pharmaceutical product and human urine was developed. The electrochemical reduction and quantitative analysis of cortisol were performed in Britton Robinson Buffer Solution (BRBS, pH 2.0) with a bare glassy carbon electrode (GCE) using cyclic voltammetry (CV) and square wave voltammetry (SWV). The compound showed one irreversible and adsorption-controlled reduction peak in CV. When SWSV mode is used, the compound yielded a well-defined voltammetric response at about -1.14 V (vs. Ag/AgCl) in BRBS at pH 2.0. Experimental results revealed an excellent linear correlation between the peak current and the concentration in the range of 1-50 µg mL-1 (2.8×10-6 -1.4×10-4 mol L-1 ). Detection and quantification limits were found to be 0.069 µg mL-1 (1.9×10-7 mol L-1 ) and 0.229 µg mL-1 (6.32×10-7 mol L1 ), respectively. Precision and accuracy of the developed method were checked by recovery studies in spiked tablets and urine.