Yazar "Kim, Doo Hwan" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    Bioactive compounds in seaweeds: An overview of their biological properties and safety
    (PERGAMON-ELSEVIER SCIENCE LTD, 2020) Rengasamy, Kannan R. R.; Mahomoodally, Mohamad Fawzi; Aumeeruddy, Muhammad Zakariyyah; Zengin, Gökhan; Xiao, Jianbo; Kim, Doo Hwan
    Seaweeds are among the significant currently exploited marine plant resources which are gaining full applications in culinary, cosmetic, pharmaceutical, and biotechnological processes. Much attention has been devoted to seaweeds based on their proven health benefits and is considered as a rich source of structurally different bioactive metabolites for the discovery of novel functional food-based pharmacophores/drugs. Nonetheless, there is still a dearth of updated compilation and analysis of the in-depth pharmacological activities of these compounds. This review, therefore, aims to provide a piece of up-to-date detailed information on the major compounds isolated from various seaweed species together with their in-vitro and in-vivo biological properties. These compounds were found to possess broad pharmacological properties and inhibitory enzyme activities against critical enzymes involved in the aetiology of noncommunicable diseases. However, their toxicity, clinical efficacy, mechanisms of action, and interaction with conventional foods, are still less explored and require more attention in future studies.
  • Küçük Resim
    Öğe
    Marine algae: A potential resource of anti-HSV molecules
    (MDPI, 2019) Mahomoodally, Mohamad Fawzi; Lobine, Devina; Rengasamy, Kannan R. R.; Gowrishankar, Shanmugaraj; Tewari, Devesh; Zengin, Gökhan; Kim, Doo Hwan; Sivanesan, Iyyakkannu
    Herpes simplex viruses (HSVs) are common human pathogens belonging to the subfamily alpha-herpesvirinae that trigger severe infections in neonates and immunocompromised patients. After primary infection, the HSVs establish a lifelong latent infection in the vegetative neural ganglia of their hosts. HSV infections contribute to substantial disease burden in humans as well as in newborns. Despite a fair number of drugs being available for the treatment of HSV infections, new, effective, and safe antiviral agents, exerting different mechanisms of action, are urgently required, mainly due to the increasing number of resistant strains. Accumulating pieces of evidence have suggested that structurally diverse compounds from marine algae possess promising anti-HSV potentials. Several studies have documented a variety of algal polysaccharides possessing anti-HSV activity, including carrageenan and fucan. This review aimed to compile previous anti-HSV studies on marine algae-derived compounds, especially sulfated polysaccharides, along with their mode of action, toward their development as novel natural anti-HSV agents for future investigations.