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    Acebutolol-induced massive pleural thickening
    (2010) Kiyan E.; Tulek B.; Kiliçaslan Z.; Yilmazbayhan D.
    Many patients take beta-blockers to control hypertension or angina, and such medication is often continued for years. Drug-induced pulmonary diseases due to beta-blockers have been published previously as pulmonary parenchymal infiltration and pleurisy, but bilateral multifocal and extensive pleural thickening alone has not been mentioned previously. In our case, Naranjo Adverse Drug Reaction probability scale score indicated that massive pleural thickening was a possible adverse reaction associated with long term use of acebutolol.
  • Küçük Resim Yok
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    Anti-inflammatory and anti-fibrotic effects of sirolimus on bleomycininduced pulmonary fibrosis in rats
    (2011) Tulek B.; Kiyan E.; Toy H.; Kiyici A.; Narin C.; Suerdem M.
    Purpose: Pulmonary fibrosis is a devastating disease with a poor prognosis. Although the diagnosis and pathophysiology of this disease have been better characterized over the past few years, there is no effective therapy for the disease. The aim of this study was to evaluate the anti-inflammatory and anti-fibrotic effects of sirolimus (SRL), which is a potential anti-fibrotic agent, by using bleomycin (BLM)-induced pulmonary fibrosis model in rats. Methods: A single intra-tracheal injection of BLM (2.5 U/kg) was administered and sirolimus (2.5 mg/kg/day) was given orally, beginning either one day before (early SRL) or nine days after (late SRL) the BLM administration. The effect of SRL on fibrosis was studied by analysis of cytokine levels in BAL fluid, measurement of lung tissue hydroxyproline (HPL) content and histopathological examination. Results: Both early and late SRL administrations caused a decrease in the levels of IL-13, PDGF-A and TGF-?1 (p=0.001) and an increase in IFN-? levels (p=0.001) in BAL fluid. Early and late SRL also caused a decrease in HPL content (p=0.001). Early sirolimus caused a significant decrease in fibrosis score (p=0.001), while late SRL did not. Conclusion: Sirolimus was effective in BLM-induced pulmonary fibrosis model, especially in the early phases of the disease. © 2011 CIM.