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    Assessment of ischaemia-modified albumin level in patients with psoriasis
    (WILEY-BLACKWELL, 2012) Ozdemir, M.; Kiyici, A.; Balevi, A.; Mevlitoglu, I.; Peru, C.
    Background. Ischaemia-modified albumin (IMA) is increased in diseases associated with oxidative stress, as detected using the albumin cobalt-binding test. Oxidative stress plays an important role in the development of psoriasis. Aim. To investigate circulating IMA levels in patients with psoriasis and its association with the disease characteristics. Methods. Serum IMA and albumin concentrations were evaluated in 26 patients with psoriasis and 26 healthy controls matched for age, gender and body mass index. Levels of albumin, IMA and adjusted IMA were compared between the groups. Results. IMA and adjusted IMA were significantly higher in patients with psoriasis [0.55 +/- 0.04 and 0.54 +/- 0.05 absorbance units (ABSU), respectively] than in healthy controls (0.38 +/- 0.04 and 0.38 +/- 0.05 ABSU, respectively). The two groups had similar albumin levels, but there was a negative correlation between IMA and albumin levels in patients with psoriasis. IMA did not correlate with any disease characteristics. Conclusions. IMA levels are higher in patients with psoriasis than in healthy controls. IMA might be produced through an adaptive response to chronic hypoxia and oxidative stress, which might play a role in the systemic inflammation seen in psoriasis.
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    The ischemia-modified albumin in childhood acute asthma exacerbation
    (WILEY-BLACKWELL, 2010) Karagol, C.; Kiyici, A.; Keles, S.; Artac, H.; Kirac, M.; Gokturk, B.; Reisli, I
    [Abstract not Available]
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    Paraoxonase activities in female migraine patients
    (BLACKWELL PUBLISHING, 2007) Kiyici, A.; Karakuscu, A.; Mehmetoglu, I.
    [Abstract not Available]
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    PLASMA LEPTIN, NEUROPEPTIDE Y, GHRELIN AND ADIPONECTIN LEVELS AND CAROTID ARTERY INTIMA MEDIA THICKNESS IN EPILEPTIC CHILDREN TREATED WITH VALPROATE
    (WILEY-BLACKWELL, 2011) Tokgoz, H.; Aydin, K.; Oran, B.; Kiyici, A.
    [Abstract not Available]
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    Radiotherapy-induced Hypopituitarism in Nasopharyngeal Carcinoma: the Tip of an Iceberg
    (JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH, 2015) Ipekci, S. H.; Cakir, M.; Kiyici, A.; Koc, O.; Artac, M.
    Background: Radiation-induced hypopituitarism is an important late complication of cranial radiotherapy in children and adults. The purpose of this cross-sectional study was to evaluate the effects of radiotherapy on pituitary function in adult nasopharyngeal carcinoma patients. Methods: Pituitary function was evaluated in 30 patients after cranial radiotherapy for nasopharyngeal carcinoma. Somatotroph and corticotroph axes were assessed by insulin tolerance test while gonadotroph and thyroid axes were evaluated by basal pituitary and end organ hormone levels at 10-133 months after radiotherapy. Results: At least one hormonal disorder was observed in 28 (93%) patients after radiotherapy. 26 (87%) patients had one or more anterior pituitary hormone deficiencies. The rates of pituitary hormone deficiencies were 77% for growth hormone, followed by adrenocorticotropic hormone (73%), thyroid-stimulating hormone (27%) and gonadotropins (7%). Hyperprolactinemia was present in 13 (43%) patients. Conclusions: Radiation-induced hypopituitarism is more common than expected in patients with nasopharyngeal carcinoma.