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    Does serum R-Spondin-1 play a role in pathophysiology of polycystic ovary syndrome?
    (Selçuk Üniversitesi, 2022) Başpınar, Osman; Şimşek, Yasin; Koçer, Derya; Dizdar, Oğuzhan Sıtkı; Topaloğlu, Hatice Kayış
    Objective: It has been thought that many novel metabolic and inflammatory markers are involved in the etiology of Polycystic ovary syndrome (PCOS). R-spondin-1 (Rspo1) is a member of the roof plate-specific spondin protein family. Rspo1 levels have been associated to obesity and insulin resistance. In this study, it was aimed to investigate whether the Rspo1 plays role in the PCOS pathophysiology. Materials and methods: This cross-sectional study included newly diagnosed, treatment-naïve PCOS patients and healthy controls. The Rspo1 levels were compared between PCOS patientsand healthy controls. In addition, the Rspo1 levels were compared within PCOSS group according to body mass index (BMI) and Ferriman Gallwey (FG) score. Results: verall, 83 subjects (47 patients with PCOS and 36 healthy controls) were included in the study. TheO PCOS and control groups were comparable regarding age and BMI. However, FG score, homeostasis model assessment of insulin resistance score, Rspo1 and total testosterone levels were significantly higher in patients with PCOS when compared to controls (p<0.001, p=0.01, p=0.02, p=0.001 respectively). In the PCOS group, there was no significant difference in the Rspo1 levels among BMI and FG scores subgroups It was also found that the Rspo1 had a significant positive correlation with total testosterone and dehydroepiandrosterone sulfate levels (p=0.03, r=0.23; p=0.08, r=0.30, respectively). Conclusion: The Rspo-1 may be associated with PCOS pathophysiology through total testosterone and dehydroepiandrosterone sulfate. Further molecular and genetic studies are needed to support this hypothesis.