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  • Küçük Resim Yok
    Öğe
    Isolated mitral valve prolapsus does not affect left ventricular function [İzole mitral kapak prolapsusu sol ventrikül fonksiyonunu etkilemez]
    (2011) Demir K.; Koc F.; Can I.; Vatankulu M.A.; Yazici M.; Ülgen M.S.
    Aim: Idiopathic mitral valve prolapsus (MVP) is characterized by myxomatous degeneration of mitral valve. The most common determinant of cardiovascular mortality in patients with MVP is left ventricular (LV) dysfunction. Therefore we aimed to evaluate LV functions of cases with isolated MVP by tissue Doppler echocardiography (TDE). Method: Twenty five patients with MVP (mean age, 31±12 years) were enrolled the study as MVP group. Control group was consisted 20 age and sex matched patients (mean age, 34±9 years) were enrolled to this study. LV functions were detected by using conventional echocardiography and TDE. Myocardial peak systolic (Sm), early (Em) and late (Am) diastolic filling velocities, Em/Am, isovolumetric contraction time (ICT), isovolumetric relaxation time (IRT) and ejection time (ET) were obtained in the basal segments of the inferior-septal and lateral wall. Myocardial performance index (MPI) was calculated. Result: Mild degree mitral regurgitation was present in 10 (40%) of patients with MVP, and moderate degree mitral regurgitation was present in 2 (8%) of patients. No difference was found between the two groups with regard to diastolic parameters. TDE-derivated MPI values were similar in all segments in two groups. There was significant difference between the two groups with regard to LV mean Sm and lateral wall Sm (11.6±2.8 vs. 9.4±1.0, p=0.001; 13.0±3.9 vs. 9.2±2.3, p=0.001 respectively). Conclusion: Isolated MVP without significant mitral regurgitation does not affect LV diastolic functions and MPI. However, Sm of late ral wall and LV mean was higher in patients with MVP than patients without MVP.
  • Küçük Resim Yok
    Öğe
    The relation of HOMA index with endothelial functions determined by flow mediated dilatation method among hyperglycemic patients
    (2007) Karaba? T.; Kaya A.; Yavuz S.; Kaya C.; Koc F.; Yeter E.
    Aims/Objective: To research the relation between "homeostasis model assessment of insulin resistance index (HOMA-IR)" and endothelial functions, determined by the flow mediated dilatation (FMD) method with brachial artery ultrasound and the atherosclerotic factors influencing these values among hyperglycemic patients taking the same type of oral antidiabethics (sulphonylurea). Method: Seventy type-2 diabetes mellitus patients (33 males and 37 females, mean age 53.5 ± 8.5 years) who took the same oral antidiabetic drugs, and 40 people (22 males, 18 females, mean age 46.9 ± 14.6 years) as control group who had no hypertension and no cardiovascular disease were included in the study. The HOMA-IR of the patients was calculated. Patients who had HOMA-IR ? 3.6 were assumed as insulin resistance (IR) existing and who had HOMA-IR < 3.6 were not existing. The groups were divided into the IR existing (group 1) and IR not existing (group 2). Endothelium dependent dilatation (FMD) values of the groups and the controls were calculated as percentage increase as to basic values in reactive hyperemia phase. Results: FMD percentages among group 1 were significantly lower than the control group (p < 0.05). No difference was observed between group 2 and the control group (p > 0.05). Percentage increase between the basic level and reactive hyperemy phase was not found statistically significant (p > 0.05) between group 1 and 2. While the main factors influencing FMD percantages were total cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein levels for group 1. No parameter could be found affecting the related percentages for group 2. Conclusion: While endothelial functions, determined by FMD method, were impaired with hyperglycemic patients whose HOMA-IR was ? 3.6; it was normal among hyperglycemics whose HOMA-IR was < 3.6.