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    The effect of aprotinin on brain ischemic-reperfusion injury after hemorrhagic shock in rats: An experimental study
    (LIPPINCOTT WILLIAMS & WILKINS, 2007) Eser, Cay; Kalkan, Erdal; Cosar, Murat; Buyukbas, Sadik; Avunduk, Mustafa Cihat; Aslan, Adem; Kocabas, Volkan
    Background. We aimed to demonstrate the positive effects of the serine protease inhibitor aprotinin on neural ischemia-reperfusion injury and apoptosis in a rat model. Methods: There were 18 rats divided into 3 groups: group A (sham, n = 6), group B (ischemia-reperfusion, n = 6), and group C (ischemia-reperfusion + aprotinin, n = 6). The systolic blood pressure of the group B and C rats was decreased to 40% to 50% of the normal level by taking blood from the femoral vein to develop hemorrhagic shock. The blood was retained and given to the remaining group B and C rats for reperfusion 20 minutes after the procedure. In group B, isotonic solution and, in group C, aprotinin was administered to the rats 5 minutes before reperfusion. After the rats were killed, the brain tissue samples were fixed for histopathologic examination. Brain tissue superoxide dismutase, malondialdehyde, and tissue myeloperoxidase level and apoptotic cell analyses were performed in all groups. Results: Superoxide dismutase level decreased from group A to group B and increased from group B to group C (p < 0.05). Malondialdehyde and myeloperoxidase levels and apoptotic cells increased from group A to group B and decreased from group B to group C (p < 0.05). Conclusions: The results suggest that the systemic use of aprotinin in ischemic neural tissue prevents reperfusion injury and also protects the morphologic, functional, and biochemical integrity of the neural tissue.
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    Ghrelin levels in children with adenoid or chronic tonsil hypertrophies before and after surgery
    (ELSEVIER IRELAND LTD, 2009) Koc, Sema; Ozturk, Kayhan; Buyukbas, Sadik; Kocabas, Volkan; Ozer, Bedri; Kara, Medine
    Objective: We aimed to evaluate the ghrelin levels in the children with adenoid or tonsil hyperthrophies. Methods: The Study included 27 children (17 boys and 10 girls). Mean age was 6.9 +/- 3.5 years, ranging from 3 to 16. Ghrelin levels in the patients and their weight and height measurements were evaluated before surgery and after 3 months later of the operation. Results: While 18 (67%) children were operated for adenoid hypertrophy, 9 (33%) children were operated for adenoid and tonsil hypertrophy. it was found that postoperative ghrelin levels were significantly decreased whereas weight and BMI scores were significantly increased (p < 0.01). A weak correlation was observed between preoperative ghrelin and weight (r = -0.29), This negative Correlation became more profound at the postoperative 3rd month examination (r = 0.85) (p < 0.01). Conclusions: The present Study showed that the surgical treatment provides positive contributions on the growing of children with adenoid and tonsil hypertrophies. The ghrelin levels were significantly decreased at the postoperative period in the children, and a negative relationship was observed between the ghrelin levels and the weight, These findings Suggest that blood ghrelin levels may be useful as a parameter for following the development of the children. (c) 2009 Elsevier Ireland Ltd. All rights reserved.