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Öğe Bis-Schiff Base Derivatives of 2,5-Dihydroxybenzaldehyde: Synthesis, Characterization and Antimicrobial Activity of Their Cu(II), Co(II) and Zn(II) Complexes(TAYLOR & FRANCIS INC, 2013) Sahin, M.; Kocak, N.; Arslan, U.; Sahin, O.; Yilmaz, M.In this study, three Schiff base ligands (N,N-Bis(2,5-dihydroxybenzylidene)-4,4- diaminodiphenylmethane (DHDPM), N,N-Bis(2,5-dihydroxybenzylidene)- 1,2- diaminoethane (DHSalen) and N,N-Bis(2,5-dihydroxybenzylidene)- 1,3-phenylenedimethanamine (DHSalomphen)) and their metal complexes were synthesized and characterized by infrared spectroscopy (IR), thermogravimetric analysis (TGA), nuclear magnetic resonance (H-1 NMR), fluorescence spectra, elemental analysis and magnetic susceptibility apparatuses. The antibacterial activity was also studied against Staphylococcus aureusATCC 29213, Streptococcus mutansRSHM 676, Enterococcus faecalisATCC 29212, Lactobacillus acidophilus RSHM 06029, Escherichia coli ATCC 25922 and Pseudomonas aeruginosaATCC 27853.Öğe Can Theranekron be an agent for inducing apoptosis and ER stress in human pancreatic cells(NATURE PUBLISHING GROUP, 2019) Kocak, N.; Duran, T.; Ucar, V. B.; Nergiz, S.; Yildirim, I.[Abstract not Available]Öğe A Case with Pallister-Killian mosaic syndrome(NATURE PUBLISHING GROUP, 2018) Cavdartepe, B. Eser; Kocak, N.; Cora, T.[Abstract not Available]Öğe Determination of distribution of chromosomes in the spreads(SPRINGER, 2009) Kocak, N.; Ozen, F.; Acar, H.[Abstract not Available]Öğe Does Tarantula cubensis venom have antipoliferative & endoplasmic reticulum stress inhibitor activity on skin cancer cells?(NATURE PUBLISHING GROUP, 2019) Duran, T.; Kocak, N.; Ucar, V. B.; Cora, T.; Nergiz, S.[Abstract not Available]Öğe Does the imbalance between agonistic and antagonistic IL-1 play a role in progression of febrile convulsions?(VERDUCI PUBLISHER, 2016) Ozen, F.; Kocak, N.; Yildirim, I. Halil; Hacimuto, G.; Sen, V.OBJECTIVE: Inflammation may play an important role in the etiopathology of febrile convulsions (FC). IL-1 beta is an important mediator of inflammation and fever is also important information of FCs. It is suggested that there may be a relationship between polymorphisms of IL-1 beta and FC. The aim of the present study is to investigate the polymorphic stituation of promoter region of IL-1 beta in two sites (-31 and -511) and assess the IL-1 RA VNTR polymorphisms in FC patients in comparison with healthy control groups. MATERIALS AND METHODS: Fifty FC patients and 50 healthy controls (HC) were included in the study. DNA extraction was performed by QIAamp DNA Mini Kit from peripheral blood lymphocytes of all subjects. IL-1 beta promoter polymorphisms were analyzed by PCR-RFLP, IL-1 RA VNTR polymorphisms were analyzed by PCR-agarose gel electrophoresis. RESULTS: Genotype distribution of IL-1 beta promoter region in position -31 was statistically different between FC patients and control groups. Allele I and allele II of IL-1 RA distribution were also statistically different in FC patients and healthy controls. CONCLUSIONS: We have found a significant association between IL-1 RA allele distribution and FC and a poor correlation of T/C substitution at the -31 position of IL-1 beta promoter in FC. Further studies are needed to investigate the gene expression levels and polymorphic situation in same samples.Öğe The frequency of MEFV gene mutation in patients admitted to hospital with preliminary diagnosis of familian mediterranean fever who undergone a prior appendectomy(VERDUCI PUBLISHER, 2012) Yolbas, I.; Ozen, F.; Kocak, N.; Kelekci, S.; Gunes, A.; Yel, S.OBJECTIVES, Familial mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent and self-limiting fever, peritonitis, arthritis, synovitis, pleuritis, carditis, and erysipelas-like lesions. The aim of this study was to investigate the frequency of the MEFV gene mutation in patients who admitted to hospital with preliminary diagnosis FMF and who had undergone a prior appendectomy. PATIENTS AND METHODS, We retrospectively reviewed the files of 52 patients between the ages of 7-18 who admitted to hospital with preliminary diagnosis of FMF and who had undergone a prior appendectomy. Age, gender and the MEFV gene mutations were included in the data. The 12 known, common MEFV gene mutations [E148Q, P369S, F479L, M680I (G/C), M680I (G/A), I692del, M694V, M694I, K695R, V726A, A744S, R761H] were investigated in the patients. RESULTS, Of these 52 cases, 29 (55.8%) were female and 23 (44.2%) were male. Their mean age was 12.1 +/- 3.1 years (range 7-18 yr). MEFV gene mutation was detected in 31/52 cases (59.6%). In this study was found an high frequency of the MEFV gene mutation in patients admitted to hospital with a preliminary diagnosis FMF who had undergone a prior appendectomy. MEFV gene mutations were M694V 16/41 (39%), E148Q 13/41 (31%), M680I 6/41 (15%), V726A 4/41 (10%) and R761H 2/41 (5%). Other genes mutations were F479L, M680I (G/A), I692del, M694I, K695R and A744S. CONCLUSION, There are too much indications of unnecessary appendectomy in MEFV gene mutation carriers. In MEFV gene mutation carriers the frequency of appendicitis can be higher than the normal population. A more detailed and extensive study should be done about it.Öğe Integrated miRNA profiling of estrogen receptor-positive breast cancer cell MCF-7(WILEY-BLACKWELL, 2015) Bozkurt, S. B.; Ozturk; Kocak, N.; Unlu, A.[Abstract not Available]Öğe Investigation of the effect of colchicine on endoplasmic reticulum stress in FMF patients(NATURE PUBLISHING GROUP, 2018) Cora, T.; Kocak, N.; Cavdartepe, B. Eser; Zainalbden, H. A.; Nergiz, S.[Abstract not Available]Öğe Investigation of the effect of theranekron on endoplasmic reticulum stress in human pancreatic cell line BXPC-3(NATURE PUBLISHING GROUP, 2019) Ucar, V. B.; Duran, T.; Kocak, N.[Abstract not Available]Öğe Investigation of the effect of thymoquinone on endoplasmic reticulum stress in human breast adenocarcinoma cells(NATURE PUBLISHING GROUP, 2018) Duran, T.; Kocak, N.; Cavdartepe, B. Eser; Nergiz, S.[Abstract not Available]Öğe Mild phenotype of a large partial 13q trisomy due to t(9;13)(NATURE PUBLISHING GROUP, 2018) Cora, T.; Kocak, N.; Cavdartepe, B. Eser; Celik, S.[Abstract not Available]Öğe A novel mutation in the TCOF1 gene in a patient with Treacher Collins syndrome(NATURE PUBLISHING GROUP, 2019) Cavdartepe, B. Eser; Kocak, N.; Yasa, N.; Cora, T.; Duymus, F.[Abstract not Available]Öğe The prevalence of Familial Mediterranean Fever common gene mutations in patients with simple febrile seizures(VERDUCI PUBLISHER, 2014) Ozen, F.; Kocak, N.; Kelekci, S.; Yildirim, I. H.; Hacimuto, G.; Ozdemir, O.BACKGROUND: Febrile seizures (FS) represent the most common form of childhood seizures that occurs in 2-5 % of the children younger than 6 years. There have been many recent reports on the molecular genetic and pathogenesis of FC. It has been recognized that there is significant genetic component for susceptibility of FC with different reported mutation. FEB1, FEB2, FEB4, SCNA1, SCNA2, GABRG2 and IL-1 beta are related to with febrile convulsions (FCs). Interleukin 1 beta (IL-1 beta) is a cytokine that contributes to febrile inflammatory responses. There are conflicting results on increasing this cytokine in serum during FC. AIM: The determine the association between mutations of MEFV gene product pyrine and febrile seizures. PATIENTS AND METHODS: The study was carried out on 104 children that were diagnosed as FS and 96 healthy children. MEFV gene mutations were detected and analyzed with Pyro-Mark Q24. PCR was performed using the Pyro-Mark PCR Kit and pyrosequencing reaction was conducted on instrument instructions. RESULTS: M694V is the most common mutation in our patient group and we found a significant association between MEFV gene mutations and FSs. Of 104 patients, 68 were heterozygotes for any mutation and 10 patients were compound. 17.7% of control group were heterozygotes for any studied mutation. Statistical analyses showed that there was strongly significant statistical difference between results obtained from FS and control group (X = 46.20, p < 0.0001). CONCLUSIONS: MEFV gene mutations, especially M694V mutation, are positively associated with FSs.Öğe Synthesis of iminooxime derivatives and investigation of their complexes(MAIK NAUKA/INTERPERIODICA/SPRINGER, 2007) Sahin, M.; Kocak, N.; Ucan, H. I.; Deveci, M. A.Three novel ligands, a-pycolyliminoisonitrosoacetophenone ((LH)-H-1 center dot HCl), alpha-pycolylimino-p-methylisonitrosoacetophenone ((LH)-H-2 center dot HCl), and a-pycolylimino-p-chloroisonitrosoacetophenone (LH)-H-3, were synthesized. Their metal complexes with Co(II), Cu(II), and Ni(II) were prepared. The mononuclear complexes of these ligands with Co2+, Cu2+, and Ni2+ ions were obtained in ethanol. The structures of the ligands and their complexes were characterized by 1H NMR, IR spectroscopy, elemental analyses, and magnetic susceptibility.