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Öğe Association of clinical androgen excess with radial artery intima media thickness in women with polycystic ovary syndrome(TAYLOR & FRANCIS LTD, 2015) Yilmaz, S. A.; Kebapcilar, A.; Koplay, M.; Kerimoglu, O. S.; Pekin, A. T.; Gencoglu, B.; Dogan, N. U.This study explores the relationship between clinical cardiovascular risk factors and clinical androgen excess, with direct comparison to radial artery intima media thickness (rIMT). rIMT of 91 patients with polycystic ovary syndrome (PCOS) were compared with 72 healthy women. Patients were divided into three groups with regard to body mass index (BMI). Group1=56 women (31 controls and 25 PCOS) with low BMI(18-22.49 kg/m(2)), Group2=36 women (15 controls and 21 PCOS) with normal BMI (22.5-24.99 kg/m(2)) and Group3=71 women (26 controls and 45 PCOS) with high BMI (25-30 kg/m(2)). rIMT was significantly higher in patients with PCOS (p=0.007). rIMT was significantly higher group1 and group3 in patients with PCOS compared to controls (p=0.007 and p=0.042, respectively). There was a significant positive association between rIMT levels and fT in women with PCOS in group1 (r=0.24, p=0.04). rIMT levels correlated to fT levels in women with PCOS in group3 (r=0.32, p=0.03). Modified Ferriman-Gallwey (mFG) scores demonstrated a positive association with free testosterone, total testosterone, free androgen index, waist circumference (WC), LH levels, insulin levels, Homeostasis Model Assessment index(HOMA-IR), rIMT and a negative correlation with sex hormone binding globulin in group1 and group2. mFG scores demonstrated a positive association with free testosterone (r=0.33, p=0.029) in group3, but no association was found between mFG and WC, HOMA-IR in group3. Our findings indicate that clinical androgen excess may be associated with cardiovascular disease in patients with PCOS.Öğe Blood flow dynamics during spinal block: more questions than answers?(WILEY-BLACKWELL, 2012) Ozbek, S.; Apiliogullari, S.; Kivrak, A. S.; Koplay, M.[Abstract not Available]Öğe Effectiveness of Shear Wave Elastography in the diagnosis of acute pancreatitis on admission(SOC ROMANA ULTRASONOGRAFE MEDICINA BIOLOGIE-SRUMB, 2018) Durmaz, Mehmet Sedat.; Arslan, Serdar.; Ozbakir, Bora.; Gungor, Gokhan.; Tolu, Ismet.; Arslan, Fatma Zeynep.; Sivri, Mesut.; Koplay, M.Aim: We aimed to investigate the effectiveness of shear wave elastography (SWE) in the diagnosis of acute pancreatitis (AP). Material and methods: The pancreatic parenchyma of 50 patients whose clinical and laboratory findings were indicative of AP and of 70 healthy, asymptomatic volunteer participants with normal laboratory values was examined using SWE. Computed tomography was performed in all patients with AP on admission. Elastographic measurements were performed by manually drawing the contours of the pancreatic parenchyma using the free region of interest. The quantitative SWE values (meters/second [m/s], kilopascal [kPa]) of the patients and asymptomatic volunteers group were compared. Results: The mean SWE value of the pancreatic parenchyma was 2.60 +/- 1.63 m/s in the asymptomatic volunteers and 3.48 +/- 0.52 m/s in patients with AP, with a statistically significant difference (p < 0.001, t=-3.685). The mean SWE value of the pancreatic parenchyma was 23.77 +/- 6.72 kPa in the asymptomatic volunteers and 45.71 +/- 10.72 kPa in patients with AP, indicating a significant difference (p < 0.001, t=-3.685). AP can be diagnosed with a sensitivity and specificity of 98.0% when 29.45 kPa was designated as cut-off value and with a 96.0% sensitivity and 98.3% specificity when 2.77 m/s was designated as the cut-off value. The superiority of SWE was found over B-mode US and CECT in the diagnosis of AP on admission. Conclusion: SWE can be used as an effective imaging method with high sensitivity and specificity for the diagnosis of AP. It may be used as an important imaging method to assist in the diagnosis of AP especially when B-mode US and CECT findings are normal.Öğe Effects of Micronised Purified Flavonoid Fraction and Oxerutin on Pain, Spermiogram and Scrotal Color Doppler Parameters in Patients with Painful Varicocele(Elsevier Science Bv, 2010) Söylemez, H.; Beytur, A.; Kılıç, S.; Oğuz, F.; Karademir, I.; Koplay, M.[Abstract not Available]Öğe Hepatobiliary and Pancreatic: Magnetic resonance imaging (MRI) features of liver involvement in adult-onset Still's disease(WILEY-BLACKWELL, 2015) Koplay, M.; Sivri, M.; Kendir, I. C.; Erdogan, H.; Yilmaz, S.[Abstract not Available]Öğe Magnetic resonance enterography with oral mannitol solution: Diagnostic efficacy and image quality in Crohn disease(ELSEVIER MASSON, 2017) Koplay, M.; Guneyli, S.; Cebeci, H.; Korkmaz, H.; Emiroglu, H. H.; Sekmenli, T.; Paksoy, Y.Purpose: The aim of this study was to investigate the diagnostic efficacy and image quality of magnetic resonance enterography (MRE) using oral mannitol solution for the evaluation Crohn disease (CD). Materials and methods: We retrospectively evaluated MRE examinations of 153 patients with an assumed or definitive diagnosis of CD. There were 65 men and 88 women, with a mean age of 35.7 years (range: 6-73 years). MRE findings of the patients were compared to histopathologic results obtained by surgery-fiberoptic endoscopy. The sensitivity, specificity and diagnostic efficacy rate were calculated. Additionally, image quality of MRE was evaluated using a four-point scale (1 = excellent, 4 = poor/non-diagnostic). Results: Sensitivity, specificity and diagnostic efficacy were 92.5%, 93% and 92.8%, respectively. Six patients had false-positive and five patients had false-negative findings. Three falsely positive patients had ulcerative colitis and three had non-specific terminal ileitis. A total of 765 small bowel segments were analyzed; 475 (62%) had an image quality score of 1 and 15 (2%), an image quality score of 4. Conclusion: MRE using oral mannitol solution provides excellent image quality for MRE and has high degrees of diagnostic efficacy in CD patients. (C) 2017 Editions francaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.Öğe Prospective ECG-gated high-pitch dual-source cardiac CT angiography in the diagnosis of congenital cardiovascular abnormalities: Radiation dose and diagnostic efficacy in a pediatric population(ELSEVIER MASSON, CORP OFF, 2016) Koplay, M.; Kizilca, O.; Cimen, D.; Sivri, M.; Erdogan, H.; Guvenc, O.; Oc, M.Purpose: The goal of this study was to investigate the radiation dose and diagnostic efficacy of cardiac computed tomography angiography (CCTA) using prospective ECG-gated high-pitch dual-source computed tomography (DSCT) in the diagnosis of congenital cardiovascular abnormalities in pediatric population. Materials and methods: One hundred five pediatric patients who were clinically diagnosed with congenital heart disease with suspected extracardiac vascular abnormalities were included in the study. All CCTAs were performed on a 128 x 2-section DSCT scanner. CCTA findings were compared with surgical and/or conventional cardiac angiography findings. Dose-length product (DLP) and effective doses (ED) were calculated for each patient. Patients were divided into 4 groups by age, and ED and DLP values were compared among groups. The image quality was evaluated using a five-point scale. Results: CCTA showed 173 abnormalities in 105 patients. There were 2 patients with false positive and 3 with false negative findings. The sensitivity and specificity of CCTA were 98.3% and 99.9%, respectively. The positive predictive value and negative predictive value of CCT were 98.9% and 99.9%, respectively. The average DLP and ED values were 15.6 +/- 9.6 (SD) mGy.cm and 0.34 +/- 0.10 (SD) mSv, respectively. The mean image quality score was 4.8 +/- 0.5 (SD) in all patients. The inter-observer agreement for the image quality scores was good (kappa = 0.80). Conclusion: CCTA is an excellent imaging modality for evaluation of cardiovascular abnormalities and provides excellent image quality with very low radiation exposure when low-dose prospective ECG-triggered high-pitch DSCT is used. (C) 2016 Editions francaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.Öğe Radiation dose and diagnostic accuracy of high-pitch dual-source coronary angiography in the evaluation of coronary artery stenoses(ELSEVIER MASSON, CORPORATION OFFICE, 2016) Koplay, M.; Erdogan, H.; Avci, A.; Sivri, M.; Demir, K.; Guler, I.; Demir, L. S.Purpose: "Flash Spiral'' imaging is a new prospective ECG-triggered spiral scan mode that uses a very high-pitch for coronary computed tomography angiography (CTA). This enables complete image acquisition within one cardiac cycle with a very low radiation exposure. The aim of this study was to investigate the diagnostic accuracy, image quality, and effective radiation dose of prospectively ECG-triggered high-pitch spiral method (Flash spiral mode) of coronary CTA using dual-source technology for the evaluation of coronary artery stenoses. Material and methods: The study included 186 consecutive patients (115 men, 71 women; mean age: 53.37 years) who underwent coronary CTA. Coronary CTA was performed with a 128 x 2-slice dual-source CT (Somatom Definition Flash, Siemens, Germany) using a prospectively ECG-triggered high-pitch spiral mode. Patients were divided into three groups according to heart rate (<= 65 bpm, 66-75 bpm, >= 76 bpm) and body mass index (BMI) (20-24 kg/m(2), 25-29 kg/m(2), 30-34 kg/m(2)) values. The correlation between heart rates, image quality and BMI values are investigated. A four-point scale (1 = excellent, 4 = poor/non-diagnostic) was used to rank the comparative image quality. Effective radiation doses were calculated. Also the correlation between radiation dose, sex and BMI values were investigated. In addition, diagnostic accuracy of CTA for detection of significant (= 50%) coronary artery stenoses was compared with invasive coronary angiography findings of 612 vessel segments in 38 patients. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy rate were calculated. Results: A total of 2976 coronary artery segments were present. Of all coronary artery segments, 2381 (80%) had an image quality score of 1, and 1.5% segments were rated as "poor/nondiagnostic". When the correlation between heart rate and image quality is investigated, there was a significant difference between < 65 bpm and > 76 bpm groups. However, there was no significant difference between < 65 bpm and 66-75 bpm groups. The mean effective dose was found as 1.3 mSv (min: 0.5, max: 2.4 mSv). The correlation between effective radiation dose and BMI was moderate. However, the correlation between gender and radiation dose was significant. Sensitivity, specificity, negative predictive value and accuracy of coronary CTA on a per -vessel segment were 90.1%, 97.4%, 98.6%, and 96.5%, respectively. Conclusions: Prospectively ECG -triggered high -pitch spiral mode coronary CTA provides high image quality and diagnostic accuracy, with very low radiation dose for evaluation and exclusion of coronary artery stenoses. (C) 2015 Editions franc aises de radiologie. Published by Elsevier Masson SAS. All rights reserved.Öğe Risk factors associated with recanalization of incompetent saphenous veins treated with radiofrequency ablation catheter(ELSEVIER MASSON, CORPORATION OFFICE, 2017) Nayman, A.; Yildiz, I.; Koca, N.; Deniz, S.; Koplay, M.; Oguzkurt, L.Purpose: The purpose of this study was to determine the occlusion rate of incompetent great saphenous veins (GSVs) and small saphenous veins (SSVs) treated with radiofrequency ablation (RFA) and individualize variables associated with recanalization. Materials and methods: A retrospective review of 311 veins (256 GSVs and 55 SSVs) in 211 patients [177 women, 34 men; mean age, 45 years +/- 12 (SD) (range: 18-75 years)] with incompetent GSVs and/or SSVs who were treated using new-generation RFA catheters was performed. The clinical results, occlusion rates, and variables associated with recanalization for the incompetent GSVs and SSVs were analyzed. Results: No major complications were observed in the study population. Ten months after RFA, the occlusion rate was 89% (227/256) for GSVs and 91% (50/55) for SSVs. An increased pre-procedure diameter of the incompetent GSVs was associated with a higher rate of recanalization (OR: 0.825; 95% CI: 0.715-0.952) (P < 0.05). No significant differences in age, gender, and side of treated veins were found between patients with recanalization of treated veins and those without recanalization. Conclusion: Our results show that pre-procedure diameter of the GSV is the single risk factor for recanalization after RFA. (C) 2016 Editions francaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.Öğe Rosary-like giant coronary artery aneurysms in Kawasaki disease: Diagnosis with prospectively ECG-gated dual source CT angiography(EDICIONES DOYMA S A, 2016) Koplay, M.; Emiroglu, M. Keser; Cimen, D.; Soylu, H.[Abstract not Available]Öğe Total anomalous pulmonary venous connection draining into the portal vein in a 2-month-old infant: multidetector computed tomography angiography diagnosis(SAGE PUBLICATIONS LTD, 2011) Onbas, O.; Koplay, M.; Kandis, H.; Besir, F. H.; Erdogmus, B.Total anomalous pulmonary venous connection (TAPVC) is a rare congenital cardiac anomaly in which the pulmonary veins fail to connect with the left atrium and connect directly to the right atrium or to one of the systemic veins. Early diagnosis and surgical correction is highly important for survival. In the evaluation of TAPVC, imaging methods such. as echocardiography, computed tomography (CT) angiography, magnetic resonance (MR) angiography, and catheter angiography have been used. We reported a rare case of infracardiac type of TAPVC draining into the portal vein at 2-mounth-old infant who was admitted to the hospital with shortness of breath and mild cyanosis. The images demonstrating TAPVC between the portal vein and the pulmonary veins with multidetector computed tomography (MDCT) angiography were also shown. (Hong Kong j.emerg.med. 2011;18:331-334)
