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Öğe Effects of fish oil on cell proliferation and liver injury in an experimental model of acute hepatic injury induced by carbon tetrachloride(COMENIUS UNIV, 2014) Korkmaz, H.; Temel, T.; Bugdaci, M. S.; Tekelioglu, Y.; Ozoran, Y.; Kapicioglu, S.Objective: We aimed to investigate the effect of fish oil on the hepatic injury and cell cycle phases as well as cellular proliferation-regeneration in a rat model of acute hepatic injury induced by carbon tetrachloride. Background: Compensatory cell proliferation and tissue regeneration occurs as an endogenous response following chemical damage to the liver and enable animals to over come the injury. Data related to effect of fish oil on liver injury induced by chemical hepatotoxicants are controversial. Method: 60 male Wistar-albino rats were fed either with a diet supplemented with 20% fish oil or standard rat feed for 2 weeks. After an overnight fast, rats in each group were administered either 1 ml/kg carbon tetrachloride or saline intraperitoneally. Results: Fish oil enriched diet significantly enhanced the carbon tetrachloride - associated necroinflammatory damage, ballooning degeneration and the elevation of serum transaminases induced by carbon tetrachloride. Furthermore fish oil diet prevented cell proliferation, increased the proportion of cells in the G0/G1phase concomitant with a decrease in the proportion of cells in the S phase cells. Conclusion: Fish oil diet exacerbates the hepatic injury and prevents cell proliferation-regeneration in normal and injured liver cells. Suppression of tissue regeneration by fish oil may lead to progression of the hepatic injury (Tab. 3, Fig. 4, Ref. 31). Text in PDF www.elis.sk.Öğe Magnetic resonance enterography with oral mannitol solution: Diagnostic efficacy and image quality in Crohn disease(ELSEVIER MASSON, 2017) Koplay, M.; Guneyli, S.; Cebeci, H.; Korkmaz, H.; Emiroglu, H. H.; Sekmenli, T.; Paksoy, Y.Purpose: The aim of this study was to investigate the diagnostic efficacy and image quality of magnetic resonance enterography (MRE) using oral mannitol solution for the evaluation Crohn disease (CD). Materials and methods: We retrospectively evaluated MRE examinations of 153 patients with an assumed or definitive diagnosis of CD. There were 65 men and 88 women, with a mean age of 35.7 years (range: 6-73 years). MRE findings of the patients were compared to histopathologic results obtained by surgery-fiberoptic endoscopy. The sensitivity, specificity and diagnostic efficacy rate were calculated. Additionally, image quality of MRE was evaluated using a four-point scale (1 = excellent, 4 = poor/non-diagnostic). Results: Sensitivity, specificity and diagnostic efficacy were 92.5%, 93% and 92.8%, respectively. Six patients had false-positive and five patients had false-negative findings. Three falsely positive patients had ulcerative colitis and three had non-specific terminal ileitis. A total of 765 small bowel segments were analyzed; 475 (62%) had an image quality score of 1 and 15 (2%), an image quality score of 4. Conclusion: MRE using oral mannitol solution provides excellent image quality for MRE and has high degrees of diagnostic efficacy in CD patients. (C) 2017 Editions francaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.Öğe A rare cause of dysphagia: hairy esophagus(GEORG THIEME VERLAG KG, 2013) Korkmaz, H.; Elsurer, C.; Temel, T.[Abstract not Available]Öğe A rare presentation of esophageal actinomycosis in an immunocompetent patient(GEORG THIEME VERLAG KG, 2013) Korkmaz, H.; Kutluana, U.; Bugdaci, M. S.; Kucukosmanoglu, I.[Abstract not Available]
