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    Effect of septoplasty on the mean platelet volume and inflammation markers
    (2018) Ulusoy, Bülent; Bozdemir, Kazım; Mişe, Halil İbrahim; Kutluhan, Ahmet; Korkmaz, Mehmet Hakan
    Objective: Nasal septal deviation is an obstructive pathology and can be related to inflammation. This study aimed to investigate therelationship between nasal septum deviation leading to obvious nasal obstruction and certain variables including mean platelet volume(MPV), platelet distribution width (PDW), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR). The study will alsoexamine the effect of this operation on this relationship.Materials and Methods: This is a prospective study. The study sample included 29 patient group participants that had septoplastyindications, and 31 control group participants that were healthy volunteers. Control and patient groups were compared with regard to MPV,PDW, NLR, PLR, platelet count and white blood cell (WBC) counts. The significance level was accepted as 0.05 in the relevant statisticalanalyses.Findings: The preoperative MPV and PDW levels were found to be higher in the patient group than the control group. The differencebetween them was statistically significant (p 0.05). In the patient group, the researchers observed a decrease of 0.72 units in the MPV valueand 0.91 units in the PDW value, and an increase of 6.72 units in the platelet count at the end of the month following the operation comparedwith the relevant values in the preoperative period (p 0.05).Result: The MPV and PDW values were high in the patients with nasal septum deviation requiring surgery. Moreover, these high MPVand PDW values were found to normalize after the operation.
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    Insufficiency of positive airway pressure treatment on increased mean platelet volume: a prospective controlled study in patients with obstructive sleep apnea syndrome
    (Springer Verlag, 2019) Ulusoy, Bülent; Oğuzhan, Tolga; Akyol, Mesut; Bozdemir, Kazım; Çiftçi, Bülent; Korkmaz, Mehmet Hakan
    Background: To analyze the association between obstructive sleep apnea syndrome (OSAS) and some hematological variables such as mean platelet volume (MPV), platelet distribution width (PDW), and the impact of positive airway pressure (PAP) treatment on these parameters. Methods: The participants of the present prospective study consist of 36 OSAS patients diagnosed with polysomnography and recommended PAP treatment and 30 healthy members as the control group. Complete blood analyses were conducted to the patient group twice; before the initiation of the PAP treatment and 1 month after regular PAP use. The control group was administered a complete blood analyses only once. Patient and control group were compared in terms of various parameters such as MPV, PDW, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), white blood cell (WBC) values, and platelet counts. Results: MPV value of the patient group was before and after PAP treatment significantly higher than the control group (respectively; Z = 2.246; p = 0.025, and Z = 2.033; p = 0.042). However, there were no statistically significant differences in the values before and after PAP treatment in the patient group (Z = 0.727; p = 0.467). In terms of platelet numbers and PDW values, no significant differences were determined (p > 0.05). Conclusion: MPV value was significantly elevated in OSAS patients. However, the 1 month of PAP treatment was insufficient in decreasing elevated MPV values. © 2019, Springer Nature Switzerland AG.