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    DETERMINATION OF DEFENSIN HNP-1 IN HUMAN SALIVA OF PATIENTS WITH ORAL MUCOSAL DISEASES
    (TAYLOR & FRANCIS INC, 2011) Kucukkolbasi, Hasan; Kucukkolbasi, Semahat; Dursun, Recep; Ayyildiz, Filiz; Kara, Huseyin
    Saliva is a biological fluid that is easily obtainable and that can give useful information both in systemic and oral diseases. In this study, a chromatographic method was applied to determine the amount of defensin HNP-1 in human saliva of patients with oral mucosal diseases before and after treatments and compared with controls. Defensin human neutrophil peptide-1 (HNP-1) was identified and confirmed. The concentration of HNP-1 in saliva was determined by comparing the area of eluted HNP-1 with that of HNP-1 standard. Linear calibration range of defensin HNP-1 was 0.10 to 0.90 mu g/10 mu L with R(2) values of 0.996. The concentrations of HNP-1 in the saliva of patients with oral lichen planus, Behcet's disease, and recurrent apthous stomatitis were 33.6 +/- 10.6, 15.5 +/- 7.6, and 36.3 +/- 9.5 mu gmL(-1) (mean +/- S.D.), respectively. The salivary defensin-1 concentration was significantly higher in patients with oral mucosal diseases than in healthy volunteers; furthermore, in patients with oral mucosal diseases, the concentration was significantly higher before treatment than after treatment.
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    Histological evaluation of the effects of bioglass, hydroxyapatite, or demineralized freeze-dried bone, grafted alone or as composites, on the healing of tibial defects in rabbits
    (SAUDI MED J, 2009) Kucukkolbasi, Hasan; Mutlu, Necip; Isik, Kubilay; Celik, Ilhami; Oznurlu, Yasemin
    Objectives: To compare the effectiveness of bioactive glass (BG), natural hydroxyapatite (HA), and demineralized freeze-dried bone (DFDB) in bone defects. Methods: All animal experiments were conducted in Faculty (if Veterinary Medicine, Selcuk University, Konya, Turkey, under the Selcuk University Guidelines for Animal Experimentation, in 2005. Eighteen New Zealand rabbits were used for the experiment. Four cavities were prepared on right and left tibias. The cavities on the right tibia were filled with either BG, HA or DFDB. One cavity was left empty as a control. The cavities on the other tibia] bone were grafted with HA+BG, DFA+DFDB, BG+DFDB and HA+BG+DFDB composites. Histological examinations were performed at first, third, and sixth postoperative months. Results: According to histomorphometric findings, the mixture containing HA+BG+DFDB obtained the best histological results (P<0.05). Conclusion: The composite graft of HA, BG and DFDB is more effective than when used as individual agents.