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    Association between Serum Total Antioxidant Status and Coronary Microvascular Functions in Patients with SLE
    (WILEY, 2012) Yilmaz, Sema; Caliskan, Mustafa; Kulaksizoglu, Sevsen; Ciftci, Ozgur; Caliskan, Zuhal; Gullu, Hakan; Guven, Aytekin
    Mortality from cardiovascular disease has been found to be increased in patients with systemic lupus erythematosus (SLE). Coronary flow reserve (CFR) measurement is used both to assess epicardial coronary arteries and to examine the integrity of coronary microvascular circulation. Oxidative stress, enhancing modification of plasma lipids, is also associated with atherosclerotic events in lupus patients. Impairment of CFR and TAS has been shown to be an early manifestation of coronary atherosclerosis. Forty patients with SLE and 33 healthy volunteers were included in this study. Echocardiographic examination included left ventricular myocardial velocity measurements and coronary flow reserve (CFR) measurement. Serum total antioxidant status levels (TAS) also were measured using TAS kit. Lateral myocardial early peak velocity (Em) and lateral Em/Am ratio did not differ between the groups, but lateral myocardial atrial peak velocity (Am) was significantly higher in SLE group than the control group. Baseline coronary diastolic peak flow velocity (DPFV) of left anterior descending was similar in both the groups. However, hyperemic DPFV and CFR (2.50 +/- 0.42 vs. 3.09 +/- 0.45, P < 0.0001) were significantly lower in the SLE group than in the control group. CFR significantly and inversely correlated with CRP and significantly correlated with TAS. Subclinical coronary microvascular dysfunction can occur in SLE patients without traditional cardiovascular risk factors, probably associated with underlying inflammation and impairment of TAS. (Echocardiography 2012;29:1218-1223)
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    The goiter prevalence and urinary iodine levels among adolescents
    (TURKISH J PEDIATRICS, 2011) Kutlu, Ruhusen; Karakose, Serdar; Gungor, Kagan; Kulaksizoglu, Sevsen
    Kutlu R, Karakose S, Gungor K, Kulaksizoglu S. The goiter prevalence and urinary iodine levels among adolescents. Turk J Pediatr 2011; 53: 161-168. Endemic goiter and iodine deficiency are among the worldwide major public health problems of today. We aimed to research the goiter prevalence and the urinary iodine level of school children. In this descriptive study, 1,847 school children in Konya aged between 10 and 18 years were included. Urinary iodine level was measured. The mean value of iodine excretion in urine was 198 +/- 46.61 mu g/L. In 40 students (2.2%), the urinary iodine level was <100 mu g/L. Six of these students (0.3%) had moderate iodine deficiency. Thyroid hyperplasia was found with palpation method in 128 students (6.9%). Ultrasonographically, five female students had solid nodule, and one male student had multiple nodules. In our study, no severe iodine deficiency was found. According to the results of our study, the mandatory iodization program in Konya has been conducted successfully.
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    Parathyroid Hormone Levels in the Prediction of Ischemic Stroke Risk
    (HINDAWI PUBLISHING CORP, 2017) Celik, Guner; Dogan, Ali; Dener, Sefik; Ozturk, Serefnur; Kulaksizoglu, Sevsen; Ekmekci, Hakan
    Objective. It was examined whether PTH and 25-dihydroxyvitamin D(25(OH)D) levels, together or separately, are indicators of the risk of stroke. Materials and Methods. This prospective study was performed at two centers. In the study, 100 patients diagnosed with acute ischemic stroke and 100 control individuals in the same age range were examined. In addition to neurological examination, cranial imaging, extensive routine blood chemistry, PTH, and 25(OH) D levels were evaluated in all cases. Stroke risk factors were determined. Logistic regression was used for statistical analysis. Results. A total of 60 patients and 79 control individuals were included in the study. Different estimation models were designed in order to examine the relationship between PTH and 25(OH) D levels with stroke. According to modeling results, it was determined that the most effective predictor for risk of stroke was 25(OH) D levels, followed by hypertension and PTH levels, respectively. Conclusion. PTH and 25(OH) D levels together can make important contributions to determination of stroke risk, and further investigations are needed to understand this relationship more fully.