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    The frequency of metabolic syndrome in patients with acrochordons
    (IBN SINA TRUST, 2017) Kurtipek, G. Saylam; Duran, Cevdet; Kutlu, Orkide; Ataseven, Arzu; Akyürek, Fatma Tunçez; Kurku, Hüseyin; Elmas, Halis
    Objective: To investigate the frequency of metabolic syndrome (MetS) in patients with acrochordons. Materials and Methods: 102 patients with acrochordons and 76 controls were enrolled into the study. The presence of MetS was evaluated under the criteria NCEP-ATP III. Results and Discussion: Waist circumference (p<0.001), body mass index (p<0.001), systolic (p=0.014) and diastolic blood pressure (p<0.001), insulin (p<0.001) and triglyceride (TG) levels (p<0.001) were higher in the group with acrochordons. The presence of MetS was found as 71.6% in patients with acrochordon and 40.8% in controls (p<0.001). Conclusions: Patients with acrochordons should be evaluated in terms of the presence of MetS and its components.
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    Frequency of metabolic syndrome in patients with knuckle pads
    (WILEY-BLACKWELL, 2015) Kurtipek, Gülcan Saylam; Kutlu, Orkide; Duran, Cevdet; Kurku, Hüseyin; Ataseven, Arzu; Akyürek, Fatma Tunçez
    Knuckle pads are hyperkeratotic, benign skin lesions that we commonly observe in obese patients. There is no study that investigates the association between metabolic syndrome (MetS) and knuckle pads. We aimed to investigate the frequency of MetS in patients with knuckle pads. Forty-seven patients with knuckle pads and 46 age-and sex-matched controls were enrolled. The presence of MetS was evaluated according to National Cholesterol Education Program-Adult Treatment Panel III criteria. In the patient group, waist circumference (P < 0.01), body mass index (BMI; P < 0.01), and systolic (P < 0.01) and diastolic blood pressure (P < 0.01) were higher than controls, and most of the patients had a history of hypertension (P < 0.01). The presence of MetS was found in 66% of the patients with knuckle pads and in 52.2% of the controls (P = 0.25). In the patient group, compared with controls, more patients had blood pressure above reference values or were on antihypertensive therapy (70.2% and 43.5%, P = 0.017, respectively), and had greater waist circumference value (93.6% and 76.1%, P = 0.038, respectively). The presence of the other three criteria were similar in both groups. Although we found similar MetS frequency in both groups, patients with knuckle pads should be examined for the presence of MetS components, especially abdominal obesity and hypertension.
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    SEVERE HYPERBILIRUBINEMIA DURING FAMILYAL MEDITERRANEAN FEVER ATTACK IN PATIENTS WITH GILBERT'S SYNDROME
    (ISTANBUL UNIV, FACULTY MEDICINE, PUBLISHING OFFICE, 2016) Kutlu, Orkide; Keskin, Muharrem; Basturk, Abdulkadir; Ecirli, Samil; Bilgic, Yilmaz; Fisekci Oktar, Sevil
    Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by fever and accompanying attacks of serositis. Cytokines such as IL-6, TNF-alpha, IL-1 beta are known to play an active role in FMF pathogenesis. Gilbert's syndrome, is a clinical condition that results indirect hyperbilirubinemia during febrile illness, surgery, vomiting and prolonged fasting period because of inhibition of UDP-glucuronide transferase activity. Increased bilirubin levels during FMF attack is caused suppression of UDP-glucuronide transferase activity by cytokines involved in the pathogenesis of FMF. Here, we report a patient who had serious indirect bilirubin elevation during an attack of FMF.