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Öğe The effects of smoking on aneuploidy and aneuploidy frequency in infertile males: a five-colour FISH study(SPRINGER, 2005) Durakbasi-Dursun, H. G.; Zamani, A. G.; Kutlu, R.; Gorkemli, H.; Bahce, M.; Acar, A.[Abstract not Available]Öğe The frequency of smoking, quitting and socio-demographic characteristics of physicians of a medical faculty(UNIV WEST INDIES FACULTY MEDICAL SCIENCES, 2006) Marakoglu, K.; Kutlu, R.; Sahsivar, S.Background. The aim of this study was to determine the epidemiology of smoking among physicians and to describe their socio-demographic characteristics. Subjects and Methods: All professors, associate professors, assistant professors, lecturers and research assistants working for the Faculty of Medicine of Meram, University of Selcuk were included in the study. Of the 500 subjects, 363 (72.6%) completed the anonymous questionnaire of the survey satisfactorily. The smoking status, age at smoking initiation, daily cigarette consumption and association between current smoking and socio-demographic variables, family characteristics and body mass index were examined The SPSS software was used to tabulate the data. The chi-square test was used for statistical analysis. Results: The mean age was 34.2 +/- 9.1 years. The rate of ever-smokers was 28.7% (n = 104). The rates of smoking in females and males were 13.4% (n = 15) and 35.6% (n = 89), respectively (P = 0.000). The rate of ex-smokers was 9.9% (n = 36). The rate of never-smokers was 61.4% (n = 223). The mean age at starting smoking was 21.7 +/- 4.9 years. The quit ratio was 25.7% (36/140) [23.3% (27/116) for men and 37.5% (9124) for women]. Fagerstrom score was averaged 2.8 +/- 2.7 among all smokers. The rate of smoking in the families (p = 0.003) and among close friends (p = 0.000) of the smoker-group was higher than in non-smokers. Conclusion: In Turkey, prevalence of tobacco smoking is high among physicians though lower than the general community. This may compromise their role in tobacco control unless they quit smoking.Öğe Y Chromosome Microdeletions in Turkish Infertile Men(2006) Zamani, Ayşe Gül; Kutlu, R.; Durakbaşı, Gül; Görkemli, H.; Acar, A.; Dursun, H.AIMS: To detect the frequency and types of both chromosomal abnormalities and Y chromosome microdeletions in infertile men attending to our university intracytoplasmic sperm injection ICSI/IVF centre and fertile control subjects in our patient population. SETTINGS AND DESIGN: A total of 50 infertile men who were referred to IVF center of Meram medical faculty were selected for the molecular azospermia factor (AZF) screening program. MATERIALS AND METHODS: Karyotype analysis and polymerase chain reaction amplification using 15 Y-specific sequence-tagged sites of AZF region were done. RESULTS: The total prevalence of chromosomal abnormalities was found to be 10% (5/50), including 4 patients with numerical and 1 patient with structural abnormalities. Overall, 4 of the 50 patients tested (8%) exhibited deletions of the Y chromosome, 3 of them being azospermic and 1 of them oligospermic men. The frequency of the microdeletions in subgroups with azospermia and oligozoospermia was found to be 10.7% (3/29) and 4.7% (1/21) respectively. Microdeletions of AZFb and AZFc regions were detected in all of the 4 patients. Neither AZFa nor AZFd microdeletions were indicated. CONCLUSIONS: Our findings suggest that one must know whether there is a genetic cause for male infertility before patients can be subjected to ISCI or testicular sperm extraction (TESE)/ISCI treatment.
