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    Effect of septoplasty on the mean platelet volume and inflammation markers
    (2018) Ulusoy, Bülent; Bozdemir, Kazım; Mişe, Halil İbrahim; Kutluhan, Ahmet; Korkmaz, Mehmet Hakan
    Objective: Nasal septal deviation is an obstructive pathology and can be related to inflammation. This study aimed to investigate therelationship between nasal septum deviation leading to obvious nasal obstruction and certain variables including mean platelet volume(MPV), platelet distribution width (PDW), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR). The study will alsoexamine the effect of this operation on this relationship.Materials and Methods: This is a prospective study. The study sample included 29 patient group participants that had septoplastyindications, and 31 control group participants that were healthy volunteers. Control and patient groups were compared with regard to MPV,PDW, NLR, PLR, platelet count and white blood cell (WBC) counts. The significance level was accepted as 0.05 in the relevant statisticalanalyses.Findings: The preoperative MPV and PDW levels were found to be higher in the patient group than the control group. The differencebetween them was statistically significant (p 0.05). In the patient group, the researchers observed a decrease of 0.72 units in the MPV valueand 0.91 units in the PDW value, and an increase of 6.72 units in the platelet count at the end of the month following the operation comparedwith the relevant values in the preoperative period (p 0.05).Result: The MPV and PDW values were high in the patients with nasal septum deviation requiring surgery. Moreover, these high MPVand PDW values were found to normalize after the operation.
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    Effects of Endoscopic Endonasal Sinus Surgery on Nasal flora in Patients with Chronic Rhinosinusitis with Nasal Polyps
    (2019) Ulusoy, Bülent; Müderris, Tuba; Çallıoğlu, Elif Ersoy; Bozdemir, Kazım; Oğuzhan, Tolga; Kutluhan, Ahmet; Açıkgöz, Ziya Cibali
    Aim: This study aimed to evaluate the alterations in the nasal flora in patients who underwent endoscopic endonasal surgery forchronic rhinosinusitis with nasal polyps (CRSwNP).Material and Methods: This prospective study included 30 patients diagnosed with CRSwNP who were resistant to medicaltreatment and recommended for surgery. The nasal cavity was sampled two times, first preoperatively on the day of operation andpostoperatively in the 4th week. Patients were divided into two groups according to their culture results, including normal florabacteria and potential pathogen production.Results: In the preoperative swab samples, 3 (11.1%) patients had no bacterial growth, 16 (59.3%) patients had a normal flora, andpotential pathogens were detected in 8 (29.6%) patients. However, postoperatively, 3 (11.1%) patients had no bacterial growth, 13(48.1%) patients had a normal flora, and potential pathogens were detected in 11 (40.7%) patients during the postoperative period.No significant difference was found between preoperative and postoperative culture results in terms of the number of patientswith normal flora, potential pathogens, and no bacterial growth (p0.676). The most common microorganism in the normal floragroup preoperative and postoperative period was coagulase-negative Staphylococcus (77.8%, 51.9%, respectively), and the mostcommon microorganism in the potential pathogen group was Staphylococcus aureus (18.5% and 25.9%, respectively). Comparingpreoperative and postoperative culture results according to isolated potential pathogen microorganism types, no statisticallysignificant difference was observed for any microorganism in the potential pathogen group (p0.05).Conclusion: As a result, no correlation between nasal polyps’ surgery and potential pathogens was detected.