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  • Küçük Resim
    Öğe
    Characteristics and Prognosis of Childhood Atopic Dermatitis: A Multicenter Study in Turkey
    (Karger, 2010) Yüksel, Hasan; Can, Demet; Reisli, İsmail; Uzuner, Nevin; Orhan, Fazıl; Cevit, Ömer; Tahan, Fulya; Canitez, Yakup; Kuyucu, Semanur; Bingöl Boz, Ayşen; Akçay, Ahmet; Yılmaz, Özge
    Background: Childhood atopic dermatitis (AD) is classically accepted as initial finding of atopic march; however, non-atopic cases do not follow this course. The aim of this study was to determine the characteristics and prognosis of AD in childhood in Turkey. Methods: The study included 531 children with AD that presented to pediatric allergy departments in 11 different regions of Turkey. Age at diagnosis, total serum and inhalant-specific immunoglobulin E (IgE) levels and allergen skin prick test results were recorded retrospectively. Clinical characteristics like additional allergic diseases at presentation or during follow-up were recorded as well as duration of follow-up. Results: Mean age at diagnosis was 37.8 +/- 36.2 months. Mean IgE level was 318.3 +/- 677.8 IU/ml (median 100 IU/ml). Skin prick tests yielded positive results in 47% of children. At presentation, 31.6% of children reported additional allergic disease, while 11.7% developed allergic disease during follow-up. Among all, 46.6% had additional allergic disease at any point. IgE levels were significantly higher in children with additional allergic diseases (p = 0.001). Allergen skin prick test positivity and family history of allergic diseases increased the risk of additional allergic diseases significantly (OR = 3.90, 95% CI = 2.3-6.6 and OR = 1.89, 95% CI = 1.3-2.8, respectively). Conclusions: Allergic sensitization is not present in all cases of AD. Coexistence of additional allergic diseases is not as high as expected but more common in children who have been demonstrated to have atopic sensitization with high IgE levels and allergen skin prick test positivity.
  • Küçük Resim
    Öğe
    Perceptions of Parents and Physicians Concerning the Childhood Asthma Control Test
    (TAYLOR & FRANCIS LTD, 2012) Uysal Soyer, Özge; Öztürk, Fadıl; Keskin, Özlem; Asilsoy, Suna; Altınel, Nazan; Karaman, Özkan; Yazıcıoğlu, Mehtap; Sapan, Nihat; Zeyrek, Dost; Kuyucu, Semanur; Özmen, Serap; Reisli, İsmail; Aydoğan, Metin; Ufuk Altıntaş, Derya; Orhan, Fazıl; Yüksel, Hasan; Bingöl Boz, Ayşen; Gürkan, Fuat; Tahan, Fulya; Cevit, Ömer; Şekerel, Bülent Enis
    Background. The Childhood Asthma Control Test (C-ACT) has been proposed to be a simple, patient-based test that is able to reflect the multidimensional nature of asthma control. In this analysis, the aim was to evaluate the perceptions of physicians and caregivers concerning C-ACT and its predictive value for future asthma-related events. Method. In a multicenter prospective design, 368 children aged 4-11 years with asthma who were either well-or not well-controlled were included in the study. The study participants were evaluated during three visits made at 2-month intervals and the Turkish version of C-ACT was completed each month. Parents completed questionnaires concerning their perception of asthma (before and after the study) and the C-ACT (after the study). Physicians completed a survey about their perception of a control-based approach and the C-ACT. Results. The C-ACT scores increased from visit 1 to visit 3, with improvement seen in all domains of the test. At the end of the study period, the parents more strongly agreed that asthma could be controlled completely and that asthma attacks and nocturnal awakenings due to asthma were preventable (p < .05). Most of the parents reported that the C-ACT helped them to determine asthma treatment goals for their children and also that the C-ACT improved communication with their physicians. The physicians indicated that a control-centered approach was more convenient (95%) and simpler (94.5%) thana severity-centered approach and provided better disease control (93.4%). A higher C-ACT score was associated with a decreased risk of asthma attack and emergency department admittance in the 2 months following the administration of C-ACT. Conclusion. Our findings indicated that the C-ACT improved both parental outlook on asthma control and the communication between the physician and parents. There was a good correlation between the C-ACT score and the level of asthma control achieved, as described by the physician. Additionally the C-ACT score was predictive of future asthma-related events. These findings suggest that the C-ACT may have an important role in asthma management in the future.