Yazar "Liorent-Martinez, Eulogio J." seçeneğine göre listele

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    Exploring chemical profiles and bioactivities of Harungana madagascariensis Lam. ex Poir. leaves and stem bark extracts: A new source of procyanidins
    (TAYLOR & FRANCIS INC, 2020) Liorent-Martinez, Eulogio J.; Ruiz-Riaguas, Alba; Sinan, Kouadio Ibrahime; Bene, Kouadio; Cordova, Maria Luisa Fernandez-de; Picot-Allain, Carene; Mahomoodally, Fawzi ‪Mohamad; Saleem, Hammad; Zengin, Gökhan
    This study attempts to valorize the multiple pharmacological properties of Harungana madagascariensis Lam. ex Poir., also known as dragon's blood tree, with wide applications in African traditional medicine. The antioxidant and inhibitory activity of H. madagascariensis leaves and stem bark extracts (ethyl acetate, aqueous extracts, and methanol) against enzymes related to diabetes (alpha-glucosidase, alpha-amylase), epidermal hyperpigmentation problems (tyrosinase), and Alzheimer's disease (acetyl and butyryl cholinesterase) were evaluated. The phytochemical profiles of the extracts were studied by high-performance liquid chromatography with diode array detection and mass spectrometry (HPLC-DAD-MS), observing the presence of procyanidins and flavonoids, particularly in the leaves' extracts. The radical scavenging and reducing power of H. madagascariensis leaves' extracts were greater than the stem bark extracts. The methanol extracts of leaves (4.61 mg galantamine equivalent (GALAE)/g extract) and stem bark (4.68 mg galantamine (GALAE)/g extract) of H. madagascariensis inhibited acetyl cholinesterase. Methanol extracts (153.55 and 147.07 mg kojic acid equivalent (KAE)/g extract, for leaves and stem bark extracts, respectively) of H. madagascariensis showed high tyrosinase inhibition. Correlation and principal component analysis (PCA) were also performed. The observed pharmacological effects of H. madagascariensis support that this plant may be a promising candidate for the development of novel pharmacophores for the treatment of diabetes, epidermal hyperpigmentation problems, Alzheimer's disease, and other oxidative-stress-related complications.
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    Syzgium coriaceum Bosser & J. Gueho-An endemic plant potentiates conventional antibiotics, inhibits clinical enzymes and induces apoptosis in breast cancer cells
    (ELSEVIER, 2020) Mahomoodally, Mohamad Fawzi; Uğurlu, Aslı; Liorent-Martinez, Eulogio J.; Nagamootoo, Meenathee; Picot-Allain, Marie Carene Nancy; Baloğlu, Mehmet Cengiz; Altunoğlu, Yasemin Çelik; Hosenally, Muzzammil; Zengin, Gökhan
    Syzygium species are renowned for being important reservoirs of phytochemicals with pharmaceutical and biomedical potential. However, no attempt has been made to delineate the pharmacological potential and phytochemical profile of Syzgtturt coriaceum Bosser & J. Gueho, an endemic plant to Mauritius. The present study aimed to determine the antibacterial, antioxidant, cytotoxicity, enzyme inhibitory and phytochemical profile of the ethyl acetate and methanol extracts of S. coriaceum. Preliminary qualitative phytochemical study of the extracts showed the presence of phenol, tannins, and alkaloids. Chemical characterisation showed the presence of derivatives of tannins, gallic acids, quercetin, and kaempferol. Potentiating activity between S. coriaceum extracts and antibiotics (ampicillin and streptomycin) using the checkerboard method showed additive interaction. The extracts showed potent 2,2-diphenyl-1-picrylhydrazyl (DPPH) (2.95 and 2.93 mmol trolox equivalent (TE)/g sample for ethyl acetate and methanol extracts, respectively) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) (4.09 and 3.83 mmol TE/g sample for ethyl acetate and methanol extracts, respectively) scavenging abilities. Syzygium coriaceum extracts were active inhibitors of alpha-glucosidase (about 47 mmol acarbose equivalent/g sample for ethyl acetate and methanol extract). S. coriaceum methanol extract caused maximum inhibition against human breast adenocarcinoma (MDA-MB-231) cancer cells after 48 h treatment with the IC50 value of 53.41 mu g/mL. Expression of anti-apoptotic Bcl2 and BIRCS genes were down-regulated. It can be concluded that S. coriaceum extracts lead to YIDA-MB-231 cells apoptosis. This investigation has provided a comprehensive report of the biological and chemical profile of S. coriaceum. Collected scientific evidences can open new avenues for research and contributes towards establishing primary data on Syzygium species endemic to Mauritius for bioprospection of novel phytopharmaceuticals.