Yazar "Maden, M" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    The importance of urinary enzyme activities in dogs with experimentally induced gentamicin nephrotoxicity
    (SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, 1999) Maden, M; Aslan, V
    Totally nine healthy and mature dogs were used in the study. Two of which were served as controls and remaining seven dogs were assigned to experimental group. Gentamicin sulphate was given to induce nephrotoxicity at the dose of 10 mg/kg body weight every 8 hours for 10 consecutive days. The samples of blood and urine were taken twice before the experiment and every other day during gentamicin infection and for 5 days after gentamicin injection was ceased. N-acetyl-beta-D-glocosaminidase (NAG), gamma-glutamyl transterase (GGT) and Alkaline phosphatase (ALP) and creatinine (CR), total protein (TP), glucose (GLU) and electrolyte (Ca, P, Na, K) concentrations in the urine samples and blood urea nitrogen (BUN), total protein (TP), albumin (ALB), cretainine (SCR), glucose and electrolytes (Ca, P, Na, K) concentrations in the blood samples were measured. Urine dip stick and microscopic examination of urine sediment were performed. Urine protein/creatinine rate and daily protein loss in urine were calculated. The fractionel clearances of electrolytes (Ca, P, Na, K) and glucose were determined. Sodium sulphanilate clearence was measured twice before the experiment and three times during the experiment. Daily clinical examination of all dogs were performed during the experiment. Autopsy and histopatologic examinations were performed in three dogs (1 control, 2 experimental group) on the 11th day of the experiment, two dogs were euthenasied due to uremic coma on the 12th day of the experiment and remaining dogs were necropsied at the end of the experiment. In this study, acute tubular necrosis induced with nephrotoxic doses of gentamicin was found to be occured between 7th and 10th days of the experiment on the basis of clinical and laboratory findings. Urine GGT activities were found to be increased (P<0.01) on the 7th day of the experiment, urine NAG and ALP activities did not significantly increase. Significant increaments in the GGT/CR (P<0.01) and NAG/CR (P<0.01), ALP/CR (P<0.05) rates were observed respectively on the 7(th) and 13(th) days of the experiment. In conclusion, GGT/CR rate was found to be the most sensitive and reliable indicator in the determination of renal tubular damage associated with gentamicin nephrotoxicity.
  • Küçük Resim
    Öğe
    The Role of Ultrasonography in the Diagnosis of Bacterial Prostatitis in Dogs
    (INDIAN VETERINARY JOURNAL, 2000) Maden, M; Birdane, F. M; Sen, I; Hadimli, H H
    This report describes a paraprostatic cyst in a sexually intact 7 years old Boxer. The clinical history of the dog revealed dysuria, hematuria, constipation and lameness in the right hind leg. An abdominal mass were discovered on clinical examination of the dog. Transabdominal ultrasonographic examination showed an abdominal mass with a cavernous pattern and a hyperechoic wall. The mass was filled with anechoic fluid and was observed to be related to the prostate and adjacent to the urinary bladder. It was decided to remove the mass surgically, Microscopic evaluation of the cystic mass revealed necrotic debris in the lumen along with fibrin, the cyst wall was rich in fibrous tissue and contained bony structures. The prostatic cyst described in this study was identified as an osseous metaplastic paraprostatic cyst on the basis of the clinical, laboratory, ultrasonographic and microscopic findings.