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  • Küçük Resim
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    A Reassessment of the International Study Group Criteria for the Diagnosis (Classification) of Behcet's Syndrome
    (Clinical & Exper Rheumatology, 2001) Tunç, R.; Uluhan, A.; Melikoğlu, Melike; Özyazgan, Y.; Özdoğan, H.; Yazıcı, Halil
    Objective Patients with ulcerative colitis (UC) and Crohn's disease (CD) were not represented in the diseased controls group that had been utilised in the development of the International Study Group (ISG) criteria for the diagnosis of Behcet's syndrome (BS). Having similar features, both of these conditions can pose problems in the differential diagnosis of BS. Moreover there has been a recent awareness of coexistence of BS and familial Mediterranean fever (FMF). The aim of this study was to reassess the performance of ISG criteria among patients with BS and other rheumatological conditions, specifically including those with CD, UC, and FMF Methods 302 consecutive patients with BS and 438 patients with other rheumatological conditions were surveyed for the presence or absence of the features of BS by, means of a standard form which had been prepared according to ISG criteria. All control patients with a history, of oral ulcer had a pathergy test and an eye examination by an experienced ophthalmologist with a slit lamp. The sensitivity and specificity of the ISG criteria were calculated. Results Seven of 302 patients with BS (2%) did not fulfil the ISG criteria while 5 of 438 controls (1%) fulfilled the ISG criteria. Conclusion In this study ISG criteria performed p well in correctly classifying BS. Further specificity studies might be considered in CD.
  • Küçük Resim
    Öğe
    Target Organ Associations in Turkish Patients With Behçet's Disease: A Cross Sectional Study by Exploratory Factor Analysis
    (2002) Tunç, Recep; Keyman, Erkani; Melikoğlu, Melike; Fresko, Izzet; Yazıcı, Hasan
    Objective. To look for target organ associations in Turkish patients with Behçet's disease (BD). Methods. We studied target organ associations in 272 consecutive patients with BD. The occurrence of any of the clinical manifestations related to BD within the previous 3 months was sought by history questionnaire completed by a rheumatologist and by physical examination. Factor analysis was used to analyze the data. Results. Four factors were identified by factor analysis of variables oral and genital ulcers, erythema nodosum, papulopustular skin lesions, uveitis, superficial and deep vein thrombosis, joint, arterial, neurological, and gastrointestinal involvement; the 4 identified factors explained 69% of the original information of the matrix. There was an association between oral ulcers, genital ulcers, and erythema nodosum (Factor 1); and between superficial and deep vein thrombosis (Factor 2). Uveitis was identified as a distinct feature, and was negatively associated with erythema nodosum (Factor 3) only among the females. There was also an association between papulopustular skin lesions and joint involvement (Factor 4). Factors 2 and 3 had higher scores in males (p = 0.001 and p = 0.009, respectively) versus females. Conclusion. We studied clinical features of BD in Turkish patients. The 4 factors we identified by factor analysis differ from a previous study from Israel, probably due to different methodologies used in the 2 studies. One factor described in our study, the association between papulopustular lesions and arthritis, supports findings of our recent study. A recognized association between superficial and deep vein thrombosis was also confirmed.