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Öğe 3 ', 4 '-dihydroxyflavonol attenuates tissue damage in unilateral testis ischemia-reperfusion in rats(COMENIUS UNIV, 2015) Duman, A.; Mogulkoc, R.; Baltaci, A. K.; Menevse, E.The purpose of this study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on oxidative damage and antioxidant system in experimental testicular torsion-detorsion. The study included 60 male Wistar albino rats. Study groups were formed as follows: 1. Control; 2. Sham; 3. 720 degrees - 4 hours torsion; 4. 720 degrees - 4 hours torsion + 4 hours detorsion; 5. 720 degrees - 4 hours torsion + DiOHF; 6. 720 degrees - 4 hours torsion + DiOHF + 4 hours detorsion; 7. 720 degrees - 4 hours torsion + 24 hours detorsion; 8. 720 degrees - 4 hours torsion + DiOHF + 24 hours detorsion. Testis were collected for the analysis of glutathione peroxidase (GPx), nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH), and xanthine oxidase (XO). GPx in the Group 8 were higher than the values in the other groups (p < 0.001). Concerning NO, the groups 3, 4, and 7 were found to have higher values than other groups (p < 0.001). MDA levels were higher in the groups 3, 7, and 8, when compared to the levels in other groups (p < 0.001). When tissue GSH levels were examined, the Group 5 had the highest GSH values (p < 0.001). With regard to XO values, the groups 3, 4, and 7 had the highest XO values (p < 0.001). The results of the study indicated that intraperitoneal DiOHF inhibited increased lipid peroxidation in testis ischemia-reperfusion injury in rats (Tab. 5, Ref. 46). Text in PDF www.elis.sk.Öğe Association between TSH status and genotypes of E23K polymorphism in KCNJ11 with gestational diabetic individuals(WILEY-BLACKWELL, 2016) Tok, M.; Menevse, E.; Arikoglu, H.; Unlu, A.; Kaya, D. Erkoc[Abstract not Available]Öğe Both experimental hypothyroidism and hyperthyroidism increase cardiac irisin levels in rats(COMENIUS UNIV, 2018) Atici, E.; Menevse, E.; Baltaci, A. K.; Mogulkoc, R.Irisin is a newly discovered myokine and adipokine that increases total body energy expenditure. The aim of this study was to determine the effect of experimental hypothyroidism and hyperthyroidism on the levels of irisin in heart tissue in rats. The study was performed on the 40 male Sprague-Dawley rats. Experimental groups were designed as; Control, Hypothyroidism, Hypothyroidism+L-Thyroxine, Hyperthyroidism and Hyperthyroidism + PTU. Following 3 weeks experimental period, irisin levels were determined in heart tissues. Hypothyroidism group values of irisin were higher than in the control group, but lower than in the hyperthyroidism group. The hyperthyroidism group had the highest levels of cardiac irisin. The results of the study showed that the experimental hypothyroidism and hyperthyroidism increased the heart irisin levels, but the increase in the hyperthyroidism group was much higher than in the hypothyroidism group. However, treatment of hypothyroidism and hyperthyroidism corrected cardiac irisin levels (Fig. 1, Ref. 28).Öğe Effect of Resveratrol Application on Lipid Peroxidation in Experimental Renal Ischemia-Reperfusion Injury in Rats(WILEY, 2017) Baltaci, A. K.; Gokbudak, H.; Mogulkoc, R.; Avunduk, M. C.; Menevse, E.[Abstract not Available]Öğe The Effects of Thyroid Dysfunction on Nesfatin-1 Levels in Rats(WILEY, 2017) Atici, E.; Menevse, E.; Baltaci, A. K.; Mogulkoc, R.[Abstract not Available]Öğe Experimental Hypothyroidism and Hyperthyroidism Have Similar Affects on Cardiac Irisin Levels in Rats(WILEY, 2017) Atici, E.; Menevse, E.; Baltaci, A. K.; Mogulkoc, R.[Abstract not Available]
