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Öğe Both hypothyroidism and hyperthyroidism increase plasma irisin levels in rats(WALTER DE GRUYTER GMBH, 2018) Atici, Emine; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim; Menevse, EsmaBackground: A recently discovered hormone, irisin is accepted to be significantly involved in the regulation of body weight. Thyroid functions may be, directly or indirectly, associated with irisin. Aim: The aim of the present study is to determine the effect of experimental thyroid dysfunction on irisin levels in rats. Methods: The study registered 40 adult male Sprague-Dawley rats, which were allocated to groups as follows: 1. Control; 2. Hypothyroidism induced by injection of 10 mg/kg/day intraperitoneal propylthiouracil (PTU) for 3 weeks; 3. Hypothyroidism (PTU 2 weeks) + L-thyroxin (1.5 mg/kg/day for 1 week); 4. Hyperthyroidism induced in rats by 3-week thyroxin (0.3 mg/kg/day); 5. Hyperthyroidism + PTU. At the end of the study, blood samples were collected to quantify free triiodothyronine (FT3), free triiodothyronine (FT4) and irisin levels. Results: FT3 and FT4 levels were reduced in hypothyroidism and were significantly elevated in hyperthyroidism (p < 0.001). Irisin values, on the other hand, were found to be elevated in both hypothyroidism and hyperthyroidism groups (p < 0.001). Conclusion: The results of the study suggest that irisin values increase in thyroid dysfunction, hypo-and hyperthyroidism, and that when hypothyroidism is corrected by thyroxin administration and hyperthyroidism by PTU injection, plasma irisin values go back to normal.Öğe The effect of 3 ', 4 '-dihydroxyflavonol on lipid peroxidation in brain ischemia-reperfusion damage in rat(WILEY-BLACKWELL, 2015) Caliskan, Merve; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim; Menevse, Esma; Ergene, Neyhan[Abstract not Available]Öğe The Effect of 3 ',4 '-Dihydroxyflavonol on Lipid Peroxidation in Rats with Cerebral Ischemia Reperfusion Injury(SPRINGER/PLENUM PUBLISHERS, 2016) Caliskan, Merve; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim; Menevse, EsmaThe aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental brain ischemia-reperfusion in rats. Present study was performed on the 34 male Wistar-albino rats, weigth 350-400 g. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; animal were anesthesized and carotid arteried were clemped for 20 min and reperfusion (7 days). 3-DiOHF + Ischemia-reperfusion; DiOHF was given to animals as 10 mg/kg by intraperitoneal. 4- Ischemia + DiOHF + Reperfusion; 5- Ischemia-reperfusion + DiOHF. Blood samples and serebral cortex were analysed for malondyaldehyde (MDA), NO (nitric oxide), xanthine oxidase (XO), glutathione (GSH) and glutathione peroxidase (GPx). Blood MDA levels were significantly higher ischemia-reperfusion groups (P < 0.005). However, DiOHF inhibited MDA. Ischemia-reperfusion led to increased XO and NO but DiOHF supplementation reduced NO and XO. DiOHF increased GSH and GPx levels compared to ischemia-reperfusion group. All together, our present study showed that intraperitoneal DiOHF supplementation has protective effect on brain ischaemia-reperfusion injury in rat.Öğe Effect of nebivolol and metoprolol treatments on serum asymmetric dimethlyarginine levels in hypertensive patients with type 2 diabetes mellitus(TURKISH SOC CARDIOLOGY, 2008) Menevse, Esma[Abstract not Available]Öğe The Effect of Pinealectomy and Melatonin Supplementation on Serum Melatonin, Nesfatin-1 and Ghrelin Levels in Rats(KARGER, 2018) Sonmez, Saadet; Baltaci, Abdulkerim Kasim; Baltaci, Saltuk Bugra; Mogulkoc, Rasim; Menevse, Esma[Abstract not Available]Öğe The Effect of the Application of Melatonin and Zinc in DMBA-Induced Mammary Carcinoma in Rats on Lipid Peroxidation and Element Metabolism(KARGER, 2018) Mutlu, Elif Gulbahce; Baltaci, Saltuk Bugra; Menevse, Esma; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim[Abstract not Available]Öğe The effect of thyroid dysfunction on nesfatin-1 and adiponectin levels in rats(WALTER DE GRUYTER GMBH, 2017) Atici, Emine; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim; Menevse, EsmaBackground: Changes in thyroid hormone concentrations may affect adiponectin concentrations through various mechanisms. A molecule released primarily from the fat cells adiposities; adiponectin has important effects on the regulation of body weight. Aim: The present study aimed to explore the effects of experimental thyroid dysfunction and its treatment on nesfatin-1 and adiponectin levels in rats. Methods: The study included 40 adult male Sprague-Dawley rats which were grouped as follows: (1) control; (2) hypothyroidism [hypothyroidism was induced by intraperitoneal injection of 10 mg/kg/day propylthiouracil (PTU) for 3 weeks]; (3) hypothyroidism + thyroxine group [after hypothyroidism was induced by 2-week PTU injection, they were treated with high-dose L-thyroxine (1.5 mg/kg/day) for 1 week]; (4) hyperthyroidism [hyperthyroidism was induced by 3-weeks' thyroxine injection (0.3 mg/kg/day)]; (5) hyperthyroidism + PTU (after hyperthyroidism was induced by 2-weeks' thyroxine injection, the animals were given 10 mg/kg/day PTU for 1 week). Blood samples taken at the end of the study were analyzed to measure nesfatin-1 and adiponectin levels. Results: It was found that nesfatin-1 levels increased in hypothyroidism, while adiponectin levels decreased (p < 0.001). In experimental hyperthyroidism, on the other hand, both nesfatin-1 and adiponectin levels were found significantly elevated (p < 0.001). Conclusion: The results of the study indicate that nesfatin-1 and adiponectin levels were modified considerably in hypo- and hyperthyroidism, whereas with the restoration of the thyroid function, modified hormone levels went back to normal.Öğe Investigation of Juglone's apoptotic effect on PANC-1 pancreatic cancer cells(LIPPINCOTT WILLIAMS & WILKINS, 2015) Asik, Aycan; Arikoglu, Hilal; Dursunoglu, Duygu; Menevse, Esma[Abstract not Available]Öğe Levels of Plasma NPY, Leptin and Nesfatin-1, and Their Relation to Zinc in Children with Obese and Metabolic Syndrome(KARGER, 2018) Aydogdu, Adnan; Baltaci, Abdulkerim Kasim; Menevse, Esma; Baltaci, Saltuk Bugra; Mogulkoc, Rasim; Erdem, Said Sami; Buyukinan, Muammer[Abstract not Available]