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    How Effective are Anti-Ageing Products?
    (TURKISH SOC DERMATOLOGY VENEROLOGY, 2009) Mevlitoglu, Inci; Engin, Burhan; Kaplan, Meltem
    Skin represents the major organ in which changes of ageing are visible. Two components are responsible for skin ageing: Intrinsic (genetic) and extrinsic (photo ageing). Intrinsic ageing is related to genetic background of individual. On the other hand, extrinsic ageing which can be prevented and delayed, is mostly related to smoking, alcohol intake, increased sun exposure, poor nutrition and hormones. Since life expectancy has increased, interests to anti-ageing have been increased. There are many topical preparations that are now being used or under investigation for anti-ageing. Even though topical medications such as tretinoin have been demonstrated in the literature to reduce the signs of ageing, patients often seek over the counter anti-ageing products. Some of the most popular ingredients used in these products are vitamins, minerals and botanical extracts. In this article, ingredients of the anti-ageing products are reviewed. (Turkderm 2009, 43 Suppl 1: 2-6)
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    Progressive Macular Hypomelanosis
    (DERI ZUHREVI HASTALIKLAR DERNEGI, 2011) Mevlitoglu, Inci; Aykol, Caner
    Progressive macular hypomelanosis (PMH) was initially described and named by Guillet in 1988. PMH is characterized by asymptomatic, ill-defined, nummular, non-scaly, hypopigmented macules, localized predominantly on the trunk. PMH is mostly seen in adolescents and young females. The etiopathogenesis of PMH is still unknown. The red follicular fluorescence becomes visible in the hypopigmented macules under Wood's lamp but is absent in normal adjacent skin. The histopathologic findings in PMH are usually non-specific, but a common feature is the decreased melanin content in the hypopigmented macules compared to the normal skin. No effective therapy is currently known. Phototherapy was found to be effective for the control of PMH; however, it does not prevent recurrence of the disease. In this paper, we aimed to review the etiopathogenesis, clinical findings, histopathology, differential diagnosis and treatment options of PMH.
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    A Randomized Comparison of Acitretin-narrow-band TL-01 Phototherapy and Acitretin-Psoralen plus Ultraviolet A for Psoriasis
    (ACTA DERMATO-VENEREOLOGICA, 2008) Oezemir, Mustafa; Engin, Burhan; Baysal, Ibrahim; Mevlitoglu, Inci
    The combination of retinoids with phototherapy enhances the efficacy of phototherapy and reduces the cumulative ultraviolet dose and duration of the therapy needed to treat chronic plaque psoriasis. Although TL-01 phototherapy has been used widely, there are few data about the effectiveness of the combination of acitretin with TL-01 in treatment of the disease. The aim of this study was to compare acitretin-narrow-band TL-01 phototherapy with acitretin-psoralen plus ultraviolet A (acitretin-PUVA) in psoriasis. We studied 60 patients with moderate to severe plaque psoriasis who were randomly allocated to three times weekly treatment acitretin-narrow-band TL-01 or acitretin-PUVA. The efficacy of treatments was assessed using the Psoriasis Area and Severity Index by a blinded observer. Clearance of psoriasis was achieved in 56.6% of patients treated with acitretin-narrow-band TL-01 and in 63.3% of those treated with acitretin-PUVA. All of these patients remained clear of psoriasis 3 months after finishing the treatments. Mucocutaneous side-effects, such as dry lips and mouth, were the most common complaints in both groups. In conclusion, acitretin-narrow-band TL-01 is an effective and well-tolerated treatment for moderate to severe plaque psoriasis, with a therapeutic effect equal to that of acitretin-PUVA.
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    Remitting Seronegative Symmetrical Synovitis With Pitting Edema in a Patient With Kaposi Sarcoma
    (LIPPINCOTT WILLIAMS & WILKINS, 2008) Oezdemir, Mustafa; Engin, Burhan; Tunc, Recep; Mevlitoglu, Inci
    [Abstract not Available]
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    Serum leptin, adiponectin, resistin and ghrelin levels in psoriatic patients treated with cyclosporin
    (WILEY-BLACKWELL, 2012) Ozdemir, Mustafa; Yuksel, Mavise; Gokbel, Hakki; Okudan, Nilsel; Mevlitoglu, Inci
    Cyclosporin has various effects on adipose tissue and glucose metabolism. This situation may lead to changes in serum levels of adipocyte-derived cytokines which have influence on the pathogenesis of psoriasis. The aim of this study was to evaluate the effect of cyclosporin treatment on some adipocyte-derived cytokines in psoriatic patients. This casecontrol study was performed between June 2009 and March 2010, at the Department of Dermatology of Meram School of Medicine. Serum leptin, adiponectin, resistin and ghrelin levels were assessed in 26 patients with psoriasis before and after cyclosporin treatment and body mass index-matched 26 healthy control subjects. The adipokines levels were compared between the groups. Serum leptin, ghrelin, resistin and adiponectin levels in patients with psoriasis before the treatment were higher than those of the control group but the differences were not statistically significant. A positive correlation between serum leptin and family history of psoriasis was detected (r = 0.398, P = 0.044). A strong negative correlation between the Psoriasis Area and Severity Index and serum ghrelin levels was seen (r = -0.52, P = 0.001) and there was a strong positive correlation between the Nail Psoriasis Severity Index and serum resistin levels (r = 0.62, P = 0.001). Following the treatment, a significant increase was seen in the serum level of adiponectin (P = 0.02) and resistin (P = 0.003). The correlations between the adipokines and the disease parameters before the treatment were lost after the treatment. Our results suggest that levels of some adipocyte-derived cytokines in psoriatic patients are affected by cyclosporin treatment.
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    Treatment of chronic urticaria with narrowband ultraviolet B phototherapy: a randomized controlled trial
    (ACTA DERMATO-VENEREOLOGICA, 2008) Engin, Burhan; Oezdemir, Mustafa; Balevi, Ali; Mevlitoglu, Inci
    Data regarding narrowband ultraviolet B (NB-UVB) phototherapy in patients with chronic urticaria is limited. The aim of this open, controlled study was to determine whether NB-UVB is effective in treating urticaria in combination with antihistamin. A total of 81 patients with chronic urticaria were recruited, 48 of whom were randomized into the NB-UVB plus antihistamine group. The control group (n = 33) received only antihistamine. Patients were assessed using the urticaria activity score and a visual analogue score (VAS). The 2 groups were evaluated at the same time-points: at treatment sessions 10 and 20 and at follow-up 3 months post-treatment. The reduction in urticaria activity score and VAS was statistically significant (p<0.05 for both groups). When comparing the groups, the mean urticaria activity score was significantly lower in the NB-UVB group at session 10 (22.6 vs. 27.3) and session 20 (17.4 vs. 20.7). Statistically significant differences were also noted in VAS between the 2 groups (p<0.01) at 3 months post-treatment. We conclude that NB-UVB may be an effective complementary treatment for patients with chronic urticaria.