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Öğe Distracted mandible does not reach the same strength as normal mandible in rabbits(ELSEVIER SCIENCE INC, 2012) Bulut, Turker; Durmus, Ercan; Mihmanli, Ahmet; Dolanmaz, Dogan; Kalayci, Abdullah; Saglam, HaciObjective. The aim of this study was to determine the resistance and fracture strength values of the bone with the use of biomechanical tests in different consolidation periods of mandibular distraction osteogenesis. Study Design. In this study, 21 mature male New Zeland rabbits were used. After distraction, rabbits were separated into 3 groups to experience 4, 8, and 12 weeks' consolidation periods. Nonoperated hemimandibles of 6 rabbits were used as a control group. After 5 days' latency period, 0.5-mm distraction was applied twice a day, i.e., 1 mm/d lengthening. After the 5-mm lengthening application, we left the animals for 1, 2, or 3 months of consolidation period. Bending stress and strength values of the bone at fracture point were measured with the use of a 3-point bending test. Results. There were significant differences between the control and 3 study groups regarding bending stress and strength values. In addition, each study group was significantly different from each other. Conclusions. Bending stress and fracture strength of the bone may not reach that of normal bone after completion of 3 months' consolidation. It should be considered to keep in place extraoral appliances or comfortable intraoral distractors for a long period. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114(suppl 5): S140-S145)Öğe Effects of Recombinant Human Erythropoietin on Mandibular Distraction Osteogenesis(W B SAUNDERS CO-ELSEVIER INC, 2009) Mihmanli, Ahmet; Dolanmaz, Dogan; Avunduk, Mustafa C.; Erdemli, EsraPurpose: To evaluate the effects of subcutaneous administration of recombinant human erythropoietin (rHuEPO) oil regeneration formation and quality during mandibular distraction osteogenesis. Materials and Methods: Sixteen adult male New Zealand rabbits were Used ill this study Ethical approval was obtained front the Animal Research Institute of Selcuk University, Konya, Turkey Subjects were randomly divided into 2 groups Distraction osteogenesis (DO) was performed witha Custom-made distractor on the left mandibles of rabbits. In the experimental group, 4 doses of 150 IU/kg rHuEPO wet-administered at 48-hour intervals. The first close was given immediately after surgery. Control subjects received 0 5 mL/kg isotonic solution in the same manner After 2 clays of latency, mandibles were distracted I mm/day at 12-hour intervals for 5 clays. A 5-mm lengthening was achieved. All animals were sacrificed after 30 days of consolidation Afterward, samples were prepared for histomorphometric evaluation of newly formed bone area. Results: The number of osteoblasts and blood vessels was significantly higher, whereas the number of osteoclasts was significantly lower, ill the experimental group than in the control group (P < 05) In the experimental group. the area of new bone formation was greater than in the control group (P < .05). Moreover. fibroblast and collagen numbers per Unit area were higher in the experimental group However, this finding was not statistically significant (P > 05) Conclusion: The subcutaneous administration of rHuEPO improves the rate and quality of bone-healing during distraction osteogenesis. However, the short-term favorable effects of rHuEPO in tills study should be extended with long-term investigations before clinical application. (C) 2009 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 67-2337-2343, 2009Öğe Management of central giant cell granuloma of the jaws with intralesional steroid injection and review of the literature(SPRINGER HEIDELBERG, 2016) Dolanmaz, Dogan; Esen, Alparslan; Mihmanli, Ahmet; Isik, KubilayWe report the results of the intralesional steroid injections for the management of central giant cell granuloma (CGCG) of the jaws. Seven CGCGs were treated with intralesional injection of corticosteroids. To accomplish this, 3.5 mL of triamcinolone and 3.5 mL of 0.5 % marcaine with 1/200,000 epinephrine (total 7 mL) were mixed. An adequate amount of steroid was injected into different areas of the lesion. This procedure was repeated on a weekly basis for 6 weeks. Clinical and radiological examination showed complete resolution and ossification of the lesions in four patients. Partial recovery was achieved in two patients. One patient did not respond to the treatment and underwent surgical curettage. We suggest that intralesional steroid injection is safe and effective for the treatment of CGCG, especially in non-aggressive lesions.Öğe Pathologic changes in soft tissues associated with asymptomatic impacted third molars(MOSBY-ELSEVIER, 2008) Yildirim, Guelsuen; Ataoglu, Hanife; Mihmanli, Ahmet; Kiziloglu, Dilek; Avunduk, Mustafa CihatObjective. The aim of this study was to examine the need for routine removal of asymptomatic impacted third molars under the prophylactic indication, based on the incidence of pathologic changes. The frequency and type of pathologic conditions associated with impacted third molars were also evaluated. Study design. One hundred twenty impacted third molar dental follicles were submitted for histopathologic examination. The association between dental follicles and pathologic changes, age, gender, and angular position were statistically evaluated. Results. Among these dental follicles, pathologic conditions were found in 23%. The relation between pathologic changes and angular position was not statistically significant (chi(2) = 2.040; P > .05). Pathologic changes were seen mostly in women who were >= 20 years old. Conclusions. Cystic changes may be developed in asymptomatic impacted third molars. Asymptomatic impacted third molars should be removed before pathologic changes can occur.
