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Öğe Both zinc deficiency and supplementation affect plasma melatonin levels in rats(2003) Bediz C.S.; Baltaci A.K.; Mogulkoc R.At physiological levels, zinc and various hormones affect each other reciprocally. Reduction in zinc levels in pinealectomized rats suggests the relation between zinc and melatonin. The effect of both zinc deficiency and supplementation on plasma melatonin levels in rats were investigated in this study. The study was done in Selçuk University, Experimental Medicine Research and Application Center. Twenty-four adult male Sprague Dawley rats were divided into 3 groups. Eight rats were fed with zinc-deficient diet. Zinc supplementation was administered intraperitoneally to 8 rats. The remaining 8 rats were used as controls. All rats sacrificed 3 weeks later. Plasma melatonin and zinc levels were determined. The plasma zinc levels of the zinc-supplemented group were higher than those of the other groups as expected (P<0.01). Similarly, the melatonin levels in the zinc-supplemented group were higher than those in the other groups. A significant decrease was observed in melatonin levels of the zinc-deficient group compared to the control and zinc-supplemented group (P<0.01). The results of this study suggest that zinc deficiency decreases the melatonin levels and zinc supplementation may increase the plasma melatonin levels in rats.Öğe The effect of 3?,4?-dihydroxyflavonol on plasma oxidant and antioxidant systems in testis ischemia-reperfusion injury in rats(AMG Transcend Association, 2018) Duman A.; Mogulkoc R.; Baltaci A.K.; Sivrikaya A.The purpose of the present study was to determine the effect of 3’,4’-dihydroxyflavonol (DiOHF) on plasma lipid peroxidation in experimental testicular torsion-detorsion.The study involved 60 Wistar-albino type male rats weighing 250-260 gr. The experiment groups were formed as follows: 1. Control; 2. Sham-control; 3.720o-4 hours torsion; 4. 720o-4 hours torsion + 4 hours detorsion; 5. 720o-4 hours torsion + DiOHF; 6. 720o-4 hours torsion + DiOHF + 4 hours detorsion; 7. 720o-4 hours torsion + 24 hours detorsion; 8. 720o-4 hours torsion + DiOHF + 24 hours detorsion. The animals in the experimental groups were anesthetized after the procedures and their blood samples were taken to determine the levels of plasma glutathione peroxidase (GPx), nitric oxide (NO), malondialdehyde (MDA), and erythrocyte glutathione (GSH). Among the study groups, group 5 was found to have the highest plasma glutathione peroxidase values (p<0.001). Groups 3 and 4, which were torsion and detorsion groups, had the lowest plasma GPx values (p<0.001).Plasma NO values were found be higher in groups 3 and 4 than all other groups (p<0.001).Groups 3, 4, and 7 had the highest plasma MDA levels (p<0.001).Erythrocyte GSH levels in groups 5 and 7 were significantly higher than the levels in other groups (p<0.001).The results of the study indicate that lipid peroxidation that increases in plasma during testis ischemia-reperfusion injury in rats is prevented by intra-peritoneal DiOHF administration. © 2018 by the authors.Öğe Effect of L-thyroxine induced hyperthyroidism on lipid peroxidation in testis and kidney tissues of rats(2007) Baltacl A.K.; Mogulkoc R.; Oztekin E.The present study was conducted to determine lipid peroxidation caused by hyperthyroidism stimulated by 3-weeks L-thyroxin in testis and kidney tissues of rats. Experimental animals were divided into control group 2, sham - hyperthyroidism group; 3, hyperthyroidism group. Malondialdehyde (MDA) and glutathione (GSH) levels were determined in testis and kidney tissues. MDA levels in the testis and kidney were significantly higher in the hyperthyroidism group than in control and sham hyperthyroidism groups (P < 0.001). GSH levels in testis and kidney were also higher in the hyperthyroidism group than those control and sham-hyperthyroidism groups (P < 0.001). The results of the present study demonstrate that the increase is more evident in testis tissue than kidney tissue.Öğe The effect of zinc supplementation on Max Vo2 and lactate levels in sedentary people(AMG Transcend Association, 2018) Kilic M.; Baltaci A.K.; Gunay M.; Okudan N.; Mogulkoc R.Results of previous studies have shown that exercise influences zinc metabolism. The importance of zinc intake by diet in athletes has been emphasized and it has been argued that zinc deficiency in the diet can have unfavorable effects on performance. The present study aims to investigate how zinc supplementation affects Max VO2 and lactate levels in sedentary people. The study included 10 male students who were not actively involved in sports. All subjects were supplemented with oral zinc sulfate (3mg/kg/day) for 4 weeks. Max VO2 and lactate levels of all subjects were determined before and after zinc supplementation. Max VO2 values of the subjects as measured after 4 weeks of zinc supplementation were numerically higher than the values measured before the supplementation, but the two values were not statistically different. Lactate levels, on the other hand, were found significantly lower after the supplementation, when compared to the levels before supplementation (p<0,05). Results of our study demonstrate that 4-week zinc supplementation leads to a significant decrease in lactate levels and delays exhaustion. Zinc supplementation can improve muscle strength and metabolism in physical activity. Consequently, physiological doses of zinc supplementation can be useful for performance. © 2018 by the authors.Öğe The effects of exogenous estradiol and progesterone with melatonin on homocvsteine levels in ovariectomized rats(2007) Oztekin E.; Mogulkoc R.; Baltaci A.K.; Ozturk B.; Tiftik A.M.The study was carried out an 24 adult, Spraque-Dawfey strain of female rats. Group 1: Control group; Group 2: Ovariectomy group; Group 3 : supplemented with esradiol and progesterone after ovariectomy. Estradiol propionate 450?g/kg and medroxyprogesterone acetate 15mg/kg were supplemented a one time every week and melatonin injection (3mg/kg/rat) was made for four weeks. Serum homocysteine levels in groups 2 and 3 were significantly higher than those in groups 1 and 4. Homocysteine levels in groups 1 and 4 were not different from each other. The findings demonstrate that ovariectomy leads to a significant increase in homocysteine levels, but hormone (estradiol and progesterone) replacement could not prevent this increase. However, this increase was suppressed by exogenous melatonin supplementation.Öğe Effects of zink deficiency and supplementation on some hematologic parameters of rats performing acute swimming exercise(2003) Baltaci A.K.; Ozyurek K.; Mogulkoc R.; Kurtoglu E.; Oztekin E.; Kul A.The aim of the study was to investigate how zinc deficiency and supplementation effect some hematologic parameters of rats performing swimming exercise. Forty adult male Spraque-Dawley rats were divided into 4 groups, zinc deficient swimmimg group (Group 1, n=10), zinc supplemented swimming group (Group 2, n=10), swimming control group (Group 3, n=10), and control group (Group 4, n=10). Blood samples were taken by decapitation and analyzed for the determination of erythrocyte, hemoglobin level, hematocrit, leukocyte, lymphocyte, platelet count and plasma zinc level at the end of the 4 week experiment. Erythrocyte count of group 1 was the lowest whereas erythrocyte count in group 3 was significantly lower than that in group 2 and 4 (p<0,05). Hemoglobin level of group 1 was significantly lower than that of groups 2 and 4 (p<0.05). Hematocrit was significantly lower in both group 1 and group 3 than both groups 2 and 4 (p<0.05). Lymphocyte count in group 2 was significantly higher than in all other groups (p<0.05). Platelet counts in group 2 was significantly lower than in all other groups (p<0.05). Our findings suggest that zinc deficiency effects the hematologic parameters mentioned negatively whereas zinc supplementation has a positive influence.Öğe Serum levels of calcium, selenium, magnesium, phosphorus, chromium, copper and iron - their relation to zinc in rats with induced hypothyroidism(2013) Baltaci A.K.; Mogulkoc R.; Belviranli M.There is an important relation between thyroid hormones and zinc. Establishment of low zinc levels in hypothyroidism and high levels in hyperthyroidism is a significant proof of this relation. The aim of the present study was to explore changes in serum levels of some elements and their relation to zinc in rats with hypothyroidism. Thirty adult male rats of Sprague-Dawley type were divided into 3 equal groups: group 1, control; group 2, sham-hypothyroidism group supplemented with 10 mg/kg serum physiologic i.p. for 4 weeks; and group 3, hypothyroidism group supplemented with 10 mg/kg propylthiouracil i.p. for 4 weeks. Blood samples were collected from all animals by decapitation and serum calcium, phosphorus, chromium, copper, iron, magnesium, selenium and zinc levels were analyzed using an atomic emission apparatus. Group 3 had lower calcium, selenium and zinc levels, and higher chromium, copper, iron and phosphorus levels (p<0.01 all) relative to groups 1 and 2. Study parameters did not differ between groups 1 and 2. Results obtained in this study indicate that hypothyroidism leads to changes in serum levels of some elements in rats. These changes may be associated with reduced zinc levels in hypothyroidism.
