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Öğe Anti-inflammatory and anti-fibrotic effects of sirolimus on bleomycin-induced pulmonary fibrosis in rats(CANADIAN SOC CLINICAL INVESTIGATION, 2011) Tulek, Baykal; Kiyan, Esen; Toy, Hatice; Kiyici, Aysel; Narin, Cuneyt; Suerdem, MecitPurpose: Pulmonary fibrosis is a devastating disease with a poor prognosis. Although the diagnosis and pathophysiology of this disease have been better characterized over the past few years, there is no effective therapy for the disease. The aim of this study was to evaluate the anti-inflammatory and anti-fibrotic effects of sirolimus (SRL), which is a potential anti-fibrotic agent, by using bleomycin (BLM)-induced pulmonary fibrosis model in rats. Methods: A single intra-tracheal injection of BLM (2.5 U/kg) was administered and sirolimus (2.5 mg/kg/day) was given orally, beginning either one day before (early SRL) or nine days after (late SRL) the BLM administration. The effect of SRL on fibrosis was studied by analysis of cytokine levels in BAL fluid, measurement of lung tissue hydroxyproline (HPL) content and histopathological examination. Results: Both early and late SRL administrations caused a decrease in the levels of IL-13, PDGF-A and TGF-beta 1 (p=0.001) and an increase in IFN-beta levels (p=0.001) in BAL fluid. Early and late SRL also caused a decrease in HPL content (p=0.001). Early sirolimus caused a significant decrease in fibrosis score (p=0.001), while late SRL did not. Conclusion: Sirolimus was effective in BLM-induced pulmonary fibrosis model, especially in the early phases of the disease.Öğe Classification of left ventricular rupture following mitral valve replacement(EKIN TIBBI YAYINCILIK LTD STI-EKIN MEDICAL PUBL, 2011) Narin, Cuneyt[Abstract not Available]Öğe The Potential Effect of Epidural Anesthesia on Mesenteric Injury after Supraceliac Aortic Clamping in a Rabbit Model(ELSEVIER SCIENCE INC, 2016) Onoglu, Rasit; Narin, Cuneyt; Kiyici, Aysel; Sarkilar, Gamze; Hacibeyoglu, Gurhan; Baba, Fusun; Sarigul, AliBackground: Epidural anesthesia is known to increase blood flow by producing vasodilatation on mesenteric circulation. In this experimental study, we aim to examine the effect of epidural anesthesia on mesenteric ischemic-reperfusion ( IR) injury induced by supracoeliac aortic occlusion in a rabbit model. Methods: Twenty-eight male white New Zealand rabbits were assigned into 4 separate groups, with 7 rabbits in each group: group I, control group; group II, IR-only group; group III, IR plus epidural anesthesia group; group IV, epidural anesthesia-only group. IR model was produced by clamping supraceliac aorta with an atraumatic vascular clamp for 60 min, followed by reperfusion for 120 min. An epidural catheter was placed via Th12-L1 intervertebral space by using open technique before aortic clamping in those assigned to epidural anesthesia. IR injury was assessed using blood markers interleukin-6 and IMA and tissue markers superoxide dismutase and malondialdehyde. Also histopathological examination was performed to evaluate the degree of injury. Results: All biochemical markers in group II were significantly elevated in comparison with the other 3 groups ( p < 0.05). This was paralleled by a more severe histopathological injury in IR-only group ( group II). The group receiving IR plus epidural anesthesia ( group III) had lower biochemical marker levels as compared with the IR-only group ( group II). Conclusions: Mesenteric IR injury that can occur during abdominal aorta surgery can be reduced by epidural anesthesia, which is commonly used during or after major operations for pain control. Controlled clinical studies are required to evaluate these findings.Öğe Repair of Coarctation-Related Aortic Arch Aneurysm and Ventricular Septal Defect in an Adolescent(TEXAS HEART INST, 2008) Narin, Cuneyt; Ege, Erdal; Orhan, Atilla; Yeniterzi, MehmetA saccular aortic arch aneurysm that is secondary to aortic arch coarctation and that is accompanied by a ventricular septal defect is a rare combination in the adolescent patient. Total simultaneous repair of all of these conditions is desirable, because of the higher morbidity and mortality rates of staged procedures-particularly when resection of the saccular aneurysm is delayed. Herein, we discuss the case of a 16-year-old boy who underwent simultaneous surgical correction of these malformations. With the aid of cardiopulmonary bypass on the beating heart, the coarctation and the aneurysmal segment were resected, and a tubular Dacron graft was interposed. The ascending aorta and femoral artery were both then cannulated to ensure whole-body perfusion during cardiopulmonary bypass. The ventricular septal defect was closed with the patient under cardioplegic arrest. After 70 days, he was discharged from the hospital without sequelae. We conclude that single-staged repair of cardiac abnormalities and of an aortic arch aneurysm that is secondary to coarctation of the aortic arch can be performed safely and effectively in adolescent and adult patients by use of our technique. (Tex Heart Inst J 2008;35(4):466-9)Öğe Surgery of left atrial myxoma as a second primary tumor in a patient previously treated for breast cancer(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2012) Narin, Cuneyt; Ege, Erdal; Onoglu, Rasit; Yazici, Mehmet; Sarigul, AliA rising level of experience and advances in cardiac surgery are leading to more operations being performed on elderly patients with other complicated diseases. But cardiac surgery in patients with malignant diseases remains a problem. Although most malignant diseases are curable, surgeons are usually reluctant to perform open heart surgery in patients with advanced tumors and a short life expectancy. Among patients undergoing open heart surgery, the incidence of malignancy is 1.2%. In this article, we present a successful atrial myxoma excision in an elderly patient with treated breast cancer using cardiopulmonary bypass and cardiac arrest.Öğe Tezosentan Reduces the Renal Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Rats(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009) Gulmen, Senol; Kiris, Ilker; Narin, Cuneyt; Ceylan, Berit Gokce; Mermi, Betul; Sutcu, Recep; Meteoglu, IbrahimBackground. Renal injury induced by aortic ischemia-reperfusion (IR) is an important factor in the development of postoperative acute renal failure following abdominal aortic surgery. Endothelin (ET) is involved in the development of renal injury induced by aortic IR and tezosentan (R0 61-0612) is a specific ET receptor antagonist. The aim of this study was to examine the effect of tezosentan on renal injury induced by abdominal aortic IR in rats. Material and Methods. Twenty-four Wistar-Albino rats were randomized into three groups (eight per group). Control group underwent laparotomy and dissection of the infrarenal abdominal aorta (IAA) without occlusion. The aortic IR group underwent laparotomy and clamping of the IAA for 120 min followed by 120 min of reperfusion. Aortic IR + tezosentan group underwent same aortic IR periods, and received a bolus intravenous injection of 10 mg/kg tezosentan before ischemia plus continuous intravenous infusion of 1 mg/kg/h tezosentan during 120 min ischemia and 120 min reperfusion. At the end of the experiment, blood and kidney tissue specimens were obtained for biochemical analysis. Histological evaluation of the rat kidney tissues was also done. Results. Biochemical analysis showed that aortic IR significantly increased (P<0.05 versus control) while tezosentan significantly decreased (P<0.05 versus aortic IR) the tissue levels of malondialdehyde, superoxide dismutase, catalase and myeloperoxidase. Histological analyses showed that aortic IR significantly increased (P<0.05 versus control) while tezosentan significantly decreased (P<0.05 versus aortic IR) focal glomerular necrosis, dilatation of Bowman's capsule, degeneration of tubular epithelium, necrosis in tubular epithelium and tubular dilatation in the renal tissue samples. Conclusion. The results of this study indicate that tezosentan reduces renal injury induced by aortic IR in rats. We think that tezosentan exerted this beneficial effect via reducing oxidative stress and lipid peroxidation, inhibition of leukocyte infiltration into renal tissue and acting cytoprotective on renal tubular cells after aortic IR. (C) 2009 Elsevier Inc. All rights reserved.
