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Öğe Anesthetic management of a patient with myasthenia gravis during cardiac surgery (case report) [Kardiyak cerrahide miyastenia gravisli hastada anestezik yaklaşim](2008) Sarkilar G.; Narin C.; Duman A.; Ökesli S.Myasthenia gravis (MG) is an autoimmune disorder mainly caused by antibodies against the muscle acetylcholine receptors at the neuromuscular junction. Loss of these receptors lead to a defect in neuromuscular transmission resulting with muscle weakness and fatigue. The use of muscle relaxants has remained controversial because patients with myasthenia gravis are known to be sensitive to their effects. The unpredictable susceptibility to muscle relaxants in patients with MG requires special considerations for anesthetic management. Experiences related to induction and maintenance of cardiac anesthesia without the use of muscle relaxant in patients with myasthena gravis are limited. In this report; induction and maintanence of anesthesia with sufentanil and propofol without neuromuscular block has been represented in a patient with MG undergoing cardiac surgery.Öğe Anti-inflammatory and anti-fibrotic effects of sirolimus on bleomycininduced pulmonary fibrosis in rats(2011) Tulek B.; Kiyan E.; Toy H.; Kiyici A.; Narin C.; Suerdem M.Purpose: Pulmonary fibrosis is a devastating disease with a poor prognosis. Although the diagnosis and pathophysiology of this disease have been better characterized over the past few years, there is no effective therapy for the disease. The aim of this study was to evaluate the anti-inflammatory and anti-fibrotic effects of sirolimus (SRL), which is a potential anti-fibrotic agent, by using bleomycin (BLM)-induced pulmonary fibrosis model in rats. Methods: A single intra-tracheal injection of BLM (2.5 U/kg) was administered and sirolimus (2.5 mg/kg/day) was given orally, beginning either one day before (early SRL) or nine days after (late SRL) the BLM administration. The effect of SRL on fibrosis was studied by analysis of cytokine levels in BAL fluid, measurement of lung tissue hydroxyproline (HPL) content and histopathological examination. Results: Both early and late SRL administrations caused a decrease in the levels of IL-13, PDGF-A and TGF-?1 (p=0.001) and an increase in IFN-? levels (p=0.001) in BAL fluid. Early and late SRL also caused a decrease in HPL content (p=0.001). Early sirolimus caused a significant decrease in fibrosis score (p=0.001), while late SRL did not. Conclusion: Sirolimus was effective in BLM-induced pulmonary fibrosis model, especially in the early phases of the disease. © 2011 CIM.Öğe Aortico-left ventricular fistula associated with infective endocarditis [İnfektif endokardit ile birlikte görülen aort-sol ventrikül arasi fistül](2010) Özdemir K.; Do?an U.; Narin C.; Paksoy Y.; Yeniterzi M.; Göktekin O.[Abstract not Available]Öğe Giant left ventricular pseudoaneurysm detected three years after myocardial infarction(2006) Soylu A.; Gök H.; Narin C.; Kayrak M.A 70-year-old male patient presented with symptoms of heart failure three years after having myocardial infarction. Transthoracic echocardiography revealed severely compromised left ventricular systolic function (ejection fraction 20%) and a large left ventricular pseudoaneurysm. The diagnosis was confirmed by computed tomography. The size of the pseudoaneurysm sac was 11 x9 cm. At surgery, the pseudoaneurysmal sac was resected and a defect of 3.5x4 cm was detected in the anterolateral wall of the left ventricle. The defect was repaired by the remodeling ventriculoplasty method of Dor. The patient whose general condition improved through intensive medical treatment was discharged with medications for heart failure and coronary artery disease on the 15th postoperative day.Öğe Mitral valve replacement in a renal transplant patient [12] [Böbrek transplantli bir hastada mitral kapak replasmani](2007) Narin C.; Ege E.; Dereli Y.; Sarigül A.[Abstract not Available]
