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Öğe The changes in biomarkers for necrotising enterocolitis in premature calves with respiratory distress syndrome(CZECH ACADEMY AGRICULTURAL SCIENCES, 2019) Yıldız, Ramazan.; Ok, Mahmut.; Ider, Merve.; Akar, Aybars.; Naseri, Amir.; Koral, Erman.The aim of this study was to determine the changes of the biomarkers used for the diagnosis of necrotising enterocolitis of human neonates in premature calves with respiratory distress syndrome (RDS). Novel biomarkers including the intestinal fatty acid binding protein (IFABP), the liver-type FABP (LFABP), trefoil factor-3 (TFF3), actin gamma 2 smooth muscle (ACTG2), and Claudin-3 were investigated using bovine specific ELISA kits. Thirty premature calves with respiratory distress syndrome (the RDS group), seven premature calves without RDS (the non-RDS group), and seven healthy calves (control) were included in the study. Blood samples from all the groups were taken at 0 and 48 h for the blood gas and biomarker measurement. It was determined that IFABP (P < 0.05), LFABP (P < 0.05), TFF3 (P < 0.05), ACTG2 (P < 0.05), and Claudin-3 (P < 0.05) in the control group were significantly higher than those in the RDS and non-RDS groups at 0 hour. The LFABP and Claudin-3 concentrations in the control group were statistically higher (P < 0.05) than those in the RDS and non-RDS groups at 48 h, whereas the ACTG2 and TFF3 contents were significantly higher (P < 0.05) than the non-RDS group. A significant increase in the contents of IFABP (P <= 0.01), LFABP (P < 0.05), TFF3 (P < 0.05), ACTG2 (P < 0.05) at 48 h was detected in the RDS group only. In conclusion, the changes in the biomarkers support the suspicion of intestinal damage such as necrotising enterocolitis (NEC) after enteral feeding in premature calves with RDS. Intestinal damage biomarkers such as IFABP, LFABP, TFF3, and ACTG2 may be useful in the diagnosis of intestinal damage in premature calves. These results also indicate that the plasma concentrations of the intestinal biomarkers change in new born calves with their gestational age.Öğe Clinical and cardiologic assessment of Anatolian shepherd dogs with asymptomatic degenerative mitral valve disease(INST ADVANCED SCIENCE EXTENSION, 2019) Turgut, Kursad.; Naseri, Amir.; Ince, Mehmet Ege.; Suleymanoğlu, Havva.; Ertan, Merve.; Sağmanligil, Vedat.; Sen, Ismail.Degenerative mitral valve disease (DMVD) is the leading cause of cardiac disease and heart failure in the dog. Advanced age, breed and male gender are well-known risk factors for DMVD. The incidence of the disease in German Shepherds seems to be noteworthy. Early diagnosis of DMVD is related to the identification of a left apical systolic murmur, characteristic of MR in a dog. Dogs with DMVD had a low frequency of arrhythmias compared to other cardiac conditions. The goal of the study was (i) to evaluate the age and gender incidences of the asymptomatic Anatolian Shepherd Dogs (ASHs) with DMVD and, (ii) to investigate the importance of its clinical, radiological, electrocardiographic (ECG) findings and the correlations of those with some echo cardio logical measurements. 35 healthy ASHs (control group) and 38 ASHs with DMVD (experimental group) were used as the materials. The severity of cardiac disease was classified according to the American College of Veterinary Internal Medicine (ACVIM) consensus statement. Thirty two dogs (84.2%) were males and 6 dogs (15.8%) were females in the experimental group. The median age, the intensity of heart murmur and the severity of mitral regurgitation (MR) of the B2 dogs were bigger (p <0.05) than that of the B1 dogs. There was a positive correlation (P<0.05) between age and mitral valve lesions (MVLs). The clinical examination assessed by cardiac auscultation (murmur) was not correlated to MVLs, VHS, ECG findings and ARJ/LAA (P>0.05). The intensity of murmur was correlated to left ventricle to aorta ratio (LA/Ao) and it was not correlated (P>0.05) to MVLs, vertebral heart scale (VHS), ECG findings and regurgitant jet area to LA area ratio (ARJ/LAA). The correlations between ECG findings and VHS, along with, LA/Ao and ARJ/LAA were positive (P <0.05). In conclusion, aging and male gender may have a significant impact on DMVD progression in ASHs. Assessment of higher murmur in group B2 might be related to the progressive severity of the illnesses. The prevalence of arrhythmia was low in asymptomatic ASHs with DMVD. P-mitrale was noteworthy. (C) 2019 The Authors. Published by IASE.Öğe Echocardiographic assessment of left ventricular systolic function in neonatal calves with naturally occurring sepsis or septic shock due to diarrhea(ELSEVIER SCI LTD, 2019) Naseri, Amir.; Sen, Ismail.; Turgut, Kursad.; Guzelbektes, Hasan.; Constable, Peter D.Sepsis is associated with clinically relevant cardiovascular changes. The objectives of this study were to evaluate the clinical value of echocardiography for monitoring left ventricular (LV) systolic function in septic calves. A prospective longitudinal study was performed using a convenience sample. Twenty septic calves and 10 healthy calves were enrolled in the study. Arterial blood pressure (BP) was measured and M-mode echocardiography performed to characterize LV systolic function; the latter included measurement of ejection fraction, EF; stroke volume, SVI and cardiac output indexed to body weight, CI; E-point of septal separation, EPSS; pre-ejection period, PEP; ejection time, LVET; ratio of PEP to LVET; velocity of circumferential shortening, Vcf, LV enddiastolic volume index (LVEDVI) and LV end-systolic volume index (LVESVI) on admission and 6, 24, 48 and 72 h later in septic calves and once in healthy calves. Admission data were compared using the Mann-Whitney U test and P < .05 was considered significant. Decreased preload and afterload were present in septic calves, as indicated by marked decreases in BP, LVEDVI, LVESVI, SVI, CI, EPSS when compared to healthy calves. Systolic function appeared adequate in septic calves, based on EF and FS compared to control calves. There was no difference in heart rate, LVET, PEP:LVET, or Vcf between septic and health calves. We conclude that circulatory dysfunction, rather than systolic dysfunction predominates in septic calves. Positive associations on admission between CI and LVEDVI, LVESVI, and SVI support this conclusion. Echocardiographic determination of LVEDVI and CI appears useful in directing treatment in septic calves.Öğe Evaluation of intestinal damage biomarkers in calves with atresia coli(WALTER DE GRUYTER GMBH, 2018) Yildiz, Ramazan.; Ok, Mahmut.; Ider, Merve.; Aydogdu, Ugur.; Naseri, Amir.; Parlak, Kurtulus.; Gulersoy, Erdem.Introduction: Intestinal obstruction such as atresia coli causes pathophysiological changes in gastrointestinal tissue due to the rise of intra-abdominal pressure. The aim of this study is to determine the intestinal damage with intestinal biomarkers in calves with atresia coli. Material and Methods: The study was conducted on 40 Holstein calves diagnosed with atresia coli with mild to moderate abdominal distention and 10 healthy Holstein calves which served as the control. Blood samples were collected from all calves, and then serum concentrations of intestinal biomarkers were estimated, namely intestinal fatty acid binding protein (IFABP), liver fatty acid binding protein (LFABP), trefoil factor 3 (TFF3), and intestinal alkaline phosphatase (IAP), using commercially available specific bovine ELISA kits. An automatic blood gas analyser was employed for determining the lactate concentration. Results: The concentrations of serum LFABP (P < 0.01), IFABP, TFF3, IAP, and blood lactate (P < 0.001) were significantly higher in calves with atresia coli than in healthy calves. Conclusion: The calves affected with atresia coli exhibited severe intestinal damage, and IFABP, LFABP, and TFF3 have significant diagnostic importance and play a useful role in determining the intestinal damage due to intestinal obstruction. High levels of IAP and lactate may serve as a signal for the development of intestinal injury.
