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Öğe Inclusion of Quercetin in Gold Nanoparticles Decorated with Supramolecular Hosts Amplifies Its Tumor Targeting Properties(American Chemical Society, 2019) Yilmaz M.; Karanastasis A.A.; Chatziathanasiadou M.V.; Oguz M.; Kougioumtzi A.; Clemente N.; Kellici T.F.Despite the anticancer potential of natural products (NPs), their limited bioavailability necessitates laborious derivatization or covalent conjugation to delivery vehicles. To unleash their potential, we developed a nanohybrid delivery platform with a noncovalently tunable surface. Initially, the active compound was encapsulated in a macrocycle, p-sulfonatocalix[4]arene, enabling a 62â000-fold aqueous solubility amplification as also a 2.9-fold enhancement in its cytotoxicity with respect to the parent compound in SW-620 colon cancer cells. A pH stimuli responsive behavior was recorded for this formulate, where a programmable release of quercetin from the macrocycle was monitored in an acidic environment. Then, a nanoparticle gold core was decorated with calixarene hosts to accommodate noncovalently NPs. The loaded nanocarrier with the NP quercetin dramatically enhanced the cytotoxicity (>50-fold) of the parent NP in colon cancer and altered its cell membrane transport mode. In vivo experiments in a mouse 4T1 tumor model showed a reduction of tumor volume in mice treated with quercetin-loaded nanoparticles without apparent toxic effects. Further analysis of the tumor-derived RNA highlighted that treatment with quercetin-loaded nanoparticles altered the expression of 27 genes related to apoptosis. © 2019 American Chemical Society.Öğe A novel colorimetric/fluorometric dual-channel sensor based on phenolphthalein and Bodipy for Sn (II) and Al (III) ions in half-aqueous medium and its applications in bioimaging(Elsevier Ltd, 2020) Gul A.; Oguz M.; Kursunlu A.N.; Yilmaz M.The aim of this study was to develop a new colorimetric and fluorometric chemosensor for Sn (II) & Al(III) detection in half aqueous medium. A new probe containing Bodipys, appended on phenolphthalein (PP-B) was synthesized with multi-step reactions. The structure of intermediate products and target compound was characterized with spectroscopic techniques. The absorption and emission properties of the synthesized PP-B probe were investigated in detail and it was deduced that PP-B probe possesses a specifically real-time, fluorometric and colorimetric response to Sn(II) and Al(III) in H2O/acetone (v/v: 1:1). The selectivity of the probe was checked in the presence of competing metal ions [Al(III), Zn(II), Cu(II), Cd(II), Fe(II), Sn(II), Hg(II), Co(II), Pb(II), Ga(III), Cr(III)]. It was found that there was a marginal difference in fluorescence response of PP-B towards Sn (II) and Al (III) in the presence of competing metal ions. Under the optimized conditions, 1:2 (ligand:metal) stoichiometries were obtained by Job's plot for Sn(II) and Al(III) complexes, respectively. Cell viability study was carried out to check the applicability of probe in human cancer cell lines. Fluorescence images of the probe (PP-B) in human lung cancer cell lines with XTT (sodium 3?-[1-[(phenylamino)-carbony]-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzene-sulfonic acid hydrate) test to detect the presence of Sn (II) and Al (III) were acquired by using a confocal laser scanning microscope. © 2020 Elsevier LtdÖğe Surface coating of magnetite nanoparticles with fluorescence derivative for the detection of mercury in water environments(Elsevier B.V., 2020) Oguz M.; Bhatti A.A.; Yilmaz M.In this study, we report synthesis of new fluorescent compound integrated with Fe3O4 nanoparticles for the detection of mercury ion (Hg2+) in aqueous environment. Fluorescent compound synthesized by reacting dansyl chloride with isonipecotic acid in one simple step reaction. The synthesized compound, dansyl-isonipecotic acid (DIA) was coated on Fe3O4 nanoparticles. Fe3O4-DIA nanoparticles have average size of 20 nm and pore size 0.3 nm as confirmed from Transmission Electron Microscope (TEM). Fluorescence study shows the quenching in intensity after addition of Hg2+ ion in Fe3O4-DIA nanoparticles solution, which is due to energy transfer from excited state of ligand to low-lying empty d-orbital of Hg2+. The quenching effect was also confirmed from confocal microscope images of Fe3O4-DIA nanoparticles. © 2020 Elsevier B.V.