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Öğe Absence of Increase in Carotid Artery Intima-Media Thickness in Infants of Diabetic Mothers(GALENOS YAYINCILIK, 2011) Atabek, Mehmet Emre; Cagan, Havva Hasret; Eklioglu, Beray Selver; Oran, BulentObjective: Infants of diabetic mothers (IDM) are considered as a risk group for atherosclerosis. Increased aortic intima-media thickness has been reported in IDM. The purpose of this study was to assess carotid artery intima-media thickness (CA-IMT), left ventricular mass index (LVMI) and atherosclerotic risk factors in IDM. Methods: Thirty IDM and 25 healthy controls were included in the study. Of these infants, 14 were appropriate-for-gestational age (AGA) and 16 were large-for-gestational age (LGA). CA-IMT and LVMI were obtained by M-mode echocardiographic examination. The relationship between parameters of atherosclerosis and echocardiographic measurements was assessed by Pearson's correlation analysis. Results: LVMI was higher in LGA IDM when compared to AGA IDM and controls. CA-IMT was not significantly different between the groups and was also not related to atherosclerotic risk factors. Serum lipid and insulin levels were higher in LGA IDM when compared with AGA IDM and controls. There were no correlations between CA-IMT, LVMI and atherosclerotic risk factors. Conclusions: In contrast to previous reports indicating an increase in CA-IMT in IDM, no differences were found between IDM and controls in this study. Our results indicate that macrosomic IDM are prone to hypertrophic cardiomyopathy but not to atherosclerotic changes in the blood vessels.Öğe Assessment of P-wave dispersion in children with atrial septal aneurysm(CAMBRIDGE UNIV PRESS, 2014) Arslan, Derya; Cimen, Derya; Guvenc, Osman; Oran, Bulent; Yilmaz, Fatma HilalBackground: This was a prospective controlled study to determine the P-wave duration and P-wave dispersion in patients with atrial septal aneurysm. Methods: A total of 41 children with atrial septal aneurysm, including 21 boys and 20 girls (mean age 11.85 +/- 3.8 years), and 32 controls, including 17 boys and 15 girls (mean age 12.3 +/- 2.9 years), were included. P-wave dispersion was calculated from the 12-lead electrocardiogram. Cardiac functions, morphology of the aneurysm, and left atrial diameter were measured using conventional echocardiography. The diagnosis of atrial septal aneurysm was made when the base of the aneurysms with an excursion ratio >= 25% was found on echocardiography. Results: There was no significant difference between the patient and control groups in demographic, clinical findings, and M-mode echocardiographic parameters. The P-wave dispersion in patients with atrial septal aneurysm was significantly longer compared with the control group (64.4 +/- 13.4 ms; p < 0.0001). Similarly, the the maximum duration of the P wave in the patient group was significantly longer compared with the control group (106.1 +/- 13.3 ms; p < 0.001). The P-wave duration and dispersion were not correlated with age, gender, systolic and diastolic blood pressure, or m-mode echocardiographic parameters. Conclusions: This study shows that P-wave dispersion is delayed in atrial septal aneurysm patients. Prolonged P-wave dispersion was determined to indicate electrical disturbance, and therefore it has an increased electrocardiographic risk of atrial arrhythmia in children with atrial septal aneurysm.Öğe Atherogenic lipid profile and systolic blood pressure are associated with carotid artery intima-media thickness in children with Turner syndrome(KARGER, 2008) Atabek, Mehmet Emre; Pyrgon, Ozgur; Oran, Bulent; Guclu, Ridvan[Abstract not Available]Öğe Case Presentation: Approach To Acute Rheumatic Fever Patient With Hepatotoxicity Due To Acetylsalicylic Acid(GALENOS YAYINCILIK, 2017) Guvenc, Osman; Cimen, Derya; Aslan, Eyup; Emiroglu, Haldun; Arslan, Derya; Oran, BulentTreatment with acetylsalicylic acid is the first choice for arthritis and mild carditis of acute rheumatic fever which is a common disease in our country. There may be many adverse reactions during treatment. 10 year-old male patient diagnosed as acute rheumatic fever had hepatotoxicity due to acetylsalicylic acid therapy. This clinic manifestation has the possibility that can be seen always in pediatric cardiology practice. This case is presented due to limited literature on the treatment of patients with hepatotoxicity.Öğe Comparison of left and right ventricular pulsed and tissue Doppler myocardial performance index values using Z-score in newborns with hypoxic-ischemic encephalopathy(TURKISH SOC CARDIOLOGY, 2011) Alp, Hayrullah; Karaaslan, Sevim; Baysal, Tamer; Oran, Bulent; Ors, RahmiObjective: The aim of the study is determination of myocardial performance index (MPI/Tei index) using pulsed (PD) and tissue Doppler (TD) techniques to show cardiac response in newborns with hypoxic-ischemic encephalopathy (HIE) and healthy newborns and eventually evaluation of the differences between these two techniques. Methods: The study is a prospective observational study. Twenty term newborns diagnosed as perinatal asphyxia during postnatal 24 hours due to the defined criteria and fifty healthy term neonates as control group were included the study. Hypoxic group was divided into two groups with Sarnat stages, Sarnat Stage 1 and 2-3. MP's (Tei indexes) were calculated with PD and TO echocardiographic techniques in all groups after the 24 hours of birth and one year later. The statistical differences between same techniques were calculated with Kruskal-Wallis test and Z score was used to compare the superiority of two techniques. Results: The MPI values calculated by PD (0.41 +/- 0.04, 0.51 +/- 0.02) and TD (0.59 +/- 0.04, 0.51 +/- 0.02) during the first day of life in Sarnat Stage 2-3 in both ventricles were significantly higher than the control group (p<0.01, p<0.02, p<0.03). While the Z score, calculated for MPI measured by PD and TD methods, were found similar in both ventricles in Sarnat Stage 1 and control groups, it was significantly different in other groups of Sarnat stages. Conclusion: The degree of cardiac response in neonates with HIE is associated with the severity of hypoxia. MPI values are not different from the controls in newborns received mild hypoxia while they are higher in the patients who were received moderate or severe hypoxia. Any advantage could not be found between two techniques according to the measurement values, but higher variability in the value of MPI, measured by TO method, calculated from moderate and severe hypoxia group was detected. (Anadolu Kardiyol Derg 2011; 11: 719-25)Öğe Coronary Arteriovenous Fistula in a Child Presenting with Chest Pain(DERMAN MEDICAL PUBL, 2016) Arslan, Derya; Cimen, Derya; Oran, Bulent; Aygul, NazifCoronary arteriovenous fistula is an incidental finding in 0.1% to 0.2% of coronary angiograms. A 15-year-old famale patient presented with a three years history of chest pain on exertion. Echocardiography was performed previously and a small muscular ventricular septal defect was detected. The electrocardiogram was normal sinus rhythm together with normal axis. On echocardiography, left ventricular function was normal and there was continuous flow into the right ventricle. Therefore, coronary angiography was performed for considering the coronary artery fistula. Coronary artery fistula was observed between the first septal perforating branch of the left anterior descending coronary artery with right ventricle. The patient's clinical follow-up was decided since a significant shunt could not be identified.Öğe The future of activity-promoting video games in clinical practice: Is it the ultimate exercise test in pre-pubertal children?(AVES PRESS LTD, 2015) Oran, Bulent; Akkurt, Alper; Arslan, Derya; Cimen, DeryaPaediatric exercise testing laboratories should accommodate subjects of various sizes and ages. To this day, games and conventional treadmill exercise tests have not been carried out in pre-pubertal children. Children cannot easily adapt to the treadmill or cycle ergometer. We therefore aim to the use of video games as a form of exercise tests in pre-pubertal children. Twenty healthy children (10 girls and 10 boys, aged 5-11 years old) were enrolled in the study. The physical examination, 12-lead electrocardiography and echocardiography were performed. The heart rate and respiratory rate were measured with systolic blood pressures. Treadmill exercise testing was performed, and electrocardiographic changes were studied during both the treadmill exercise test with Bruce protocol and an activity-promoting video game (Nintendo Wii Boxing), in different time periods. Exercises were stopped at the target heart rate.The mean duration of exercise was 15 minutes in both the Bruce protocol and the activity-promoting video game. Although the data of healthy children (including heart rate and blood pressure responses to exercise) were consistent with the results from several countries using the Bruce protocol, the mean maximal heart rates for all groups were slightly lower than those obtained with the video game. The data obtained from this new exercise test may be used to determine the diagnosis and activation of cardiovascular disease in pre-pubertal children. It can be used as an exercise test especially in young children who are unable to use the treadmill or cycle ergometerÖğe Growth-differentiation factor-15 and tissue doppler imaging in detection of asymptomatic anthracycline cardiomyopathy in childhood cancer survivors(PERGAMON-ELSEVIER SCIENCE LTD, 2013) Arslan, Derya; Cihan, Tugba; Kose, Dogan; Vatansev, Husamettin; Cimen, Derya; Koksal, Yavuz; Oran, BulentObjectives: Anthracyclines have led to an increased risk of cardiac morbidity and mortality. Late cardiac complications in cancer survivors may develop from subclinical myocardial damage. Tissue Doppler imaging (TDI) also has potential as a clinically useful technique for the assessment of myocardial function. Biochemical markers may be used to detect cardiac damage growth-differentiation factor-15 (GDF-15) and are emerging as a biomarker of cardiac dysfunction. The aim of this study is to assess the value of the plasma levels of GDF-15 and TDI in detecting late myocardial dysfunction in childhood cancer survivors (CCS) who were treated with anthracyclines. Design and methods: Thirty-eight CCS who had completed chemotherapy treatment with anthracyclines were included in this study. Control group consisted of 32 age- and gender-matched healthy volunteers. All children underwent a detailed echocardiography, which contained an M-mode, pulse Doppler and tissue Doppler imaging. However, GDF-15 and cardiac troponin-I (cTnI) were measured. Results: Although, systolic function of the left ventricular was similar in all groups, there were significant differences between parameters of diastolic function of the heart. The mitral valve E wave, E/A ratio, left ventricular E'm wave, and E'm/A'm ratio were different in the patients than in the controls (p = 0.049, p = 0.037, p < 0.0001, p = 0.001, respectively). The tricuspid valve E/A ratio, right ventricular E't wave, and E't/A't ratio in the patients were also different from those of the controls (p = 0.031, p < 0.0001, p < 0.0001, respectively). Mean plasma GDF-15 was significantly higher in patients than healthy controls (p = 0.027). There were no significant differences in cTnI between both groups. Conclusions: Growth-differentiation factor-15 level may be used as a biomarker of anthracycline-induced cardiovascular disease severity in the CCS. (c) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.Öğe Hemitruncus Arteriosus: Cardiac Magnetic Resonance Angiography Findings(Wiley Periodicals, Inc, 2012) Koplay, Mustafa; Erol, Cengiz; Paksoy, Yahya; Uysal, Emine; Arslan, Derya; Oran, BulentHemitruncus arteriosus (HA) is an uncommon congenital cardiac malformation in which one pulmonary artery branch originates from the ascending aorta. A 2-month-old male was referred to our hospital for failure to thrive, cyanosis, and tachypnea. A chest radiograph demonstrated moderate cardiomegaly and peribronchial thickening. Echocardiography demonstrated right atrial and ventricular enlargement and increased gradient (25 mm Hg) in the right pulmonary artery. Cardiac magnetic resonance angiography was performed and clearly revealed typical imaging findings of a right HA which had complex cardiac and vascular anatomy. This case report presents cardiac magnetic resonance angiography findings of HA.Öğe Heparin-Induced Thrombocytopenia Association with Impaired Liver Function Tests(DERMAN MEDICAL PUBL, 2016) Arslan, Derya; Guvenc, Osman; Cimen, Derya; Oran, BulentHeparin-induced thrombocytopenia is an intensely procoagulant disorder and carries significant morbidity and mortality. However, the elevations in serum aminotransferases are characteristically asymptomatic and reversible with treatment termination. The serious liver injury due to heparins has not been reported but liver function should be monitored closely since potential severe liver damage with hepatocyte necrosis can occur. In this case report, we present a one-year-old male patient who developed a left lower extremity arterial thrombosis following an pulmonary artery banding procedure. Our case was taking unfractionated heparin for anticoagulation. On the third day of heparin therapy, routine blood analysis revealed deranged hepatic function tests and thrombocytopenia. Unfractionated heparin treatment was discontinued and he was treated with therapeutic doses of low-molecular-weight heparin for arterial thrombosis. His platelet count and liver function tests had normalised 2 weeks later.Öğe Homocysteine levels and total antioxidant capacity in children with acute rheumatic fever(PERGAMON-ELSEVIER SCIENCE LTD, 2008) Kurban, Sevil; Mehmetoglu, Idris; Oran, Bulent; Kiyici, AyselObjective: The aim of the study was to investigate total antioxidant capacity (TAC) and homocysteine levels in children with acute rheumatic fever (ARF). Design and methods: Nineteen patients with ARE and twenty healthy children, age- and sex-matched were included in the study. Follow-up studies were made at the 7(th), 14(th), 21(st) and 28(th) day of diagnosis. Results: Children with ARF had significantly higher serum homocysteine levels and lower TAC than the same parameters of the controls at all measurements. Following the anti-inflammatory therapy, we found a progressive increase in TAC and a decrease in homocysteine levels of the patients. Conclusion: We concluded that increased serum homocysteine levels and decreased serum TAC of the patients with ARF can be considered as a sign of increased inflammation and oxidative stress in these patients which needs to be considered during therapy. Further studies are needed to understand the underlying mechanisms of these findings. (c) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.Öğe The importance of troponin-I as a predictor of cardiac injury caused by carbon monoxide poisoning(TAYLOR & FRANCIS INC, 2007) Unal, Ekrem; Yazar, Abdullah; Oran, Bulent[Abstract not Available]Öğe Is Myocardial Performance Index Useful in Differential Diagnosis of Moderate and Severe Hypoxic-İschaemic Encephalopathy? A Serial Doppler Echocardiographic Evaluation(Cambridge Univ Press, 2012) Karaarslan, Sevim; Alp, Hayrullah; Baysal, Tamer; Çimen, Derya; Örs, Rahmi; Oran, BulentIntroduction: The aim of this study was to investigate the importance of myocardial performance index as an additive criterion to Sarnat criteria in differential diagnosis of newborn babies with moderate and severe hypoxic-ischaemic encephalopathy. Methods: Our study group included 50 healthy term newborn babies and 20 newborn babies with hypoxic ischaemic encephalopathy. The 20 newborn babies with hypoxic-ischaemic encephalopathy were scored using Sarnat grades. Left and right ventricular functions were determined on the first day and thereafter in the 1, 3-4, 6-7, and 11-12 months of life by M-Mode and pulsed Doppler. Results: Myocardial performance indexes of the left ventricle were significantly higher in the severe hypoxic ischaemic encephalopathy group than in the control group during the first, second, and third analyses (p = 0.01, p = 0.02, p = 0.02, respectively) and only during the first analysis (p = 0.01) in the moderate hypoxic-ischaemic encephalopathy group. In addition, the myocardial performance indexes of the right ventricle were significantly higher during the first, second, and third analyses in both severe and moderate hypoxic-ischaemic encephalopathy groups than in the control group (p = 0.01, all). Hypoxia-induced alterations last longer in the right ventricle than in the left ventricle in the moderate group, as during the second and third analyses myocardial performance index continues to be higher than the control group. Conclusion: Myocardial performance indexes for the left and right ventricles were significantly higher in both severe and moderate hypoxic-ischaemic encephalopathy groups than in the control group during the first analysis, and myocardial performance index greater than or equal to 0.5 can be used in order to distinguish moderate and severe hypoxic-ischaemic encephalopathy babies according to Sarnat grades as a discriminative additive criterion.Öğe Ischemia-Modified Albumin as a Marker of Acute Coronary Syndrome: The Case for Revising the Concept of "N-Terminal Modification" to "Fatty Acid Occupation" of Albumin(HINDAWI LTD, 2017) Oran, Ismail; Oran, BulentIschemia-modified albumin (IMA) is assumed "N-terminal modified" albumin which is generated immediately following myocardial ischemia. The diagnosis of IMA is based on reduced cobalt binding affinity to albumin which is attributed mainly to incapability of cobalt to bind at albumin's modified N-terminus. Although the albumin cobalt binding test was accepted as a potentially powerful marker for discriminating acute coronary syndrome from nonischemic chest pain, its usefulness has been brought into question in recent years. Patients with acutely ischemic myocardium exhibit a rapid increase in serum levels of fatty acids (FAs). Almost all released FAs are strongly bound to albumin which create conformational changes in the protein with resultant reduced cobalt binding affinity. There is a clear metabolic and temporal relationship between IMA measured via albumin cobalt binding testing and serum levels of FAs. In line with what has been suggested recently in the literature, we conclude that a shift from the concept of "N-terminal modified" to "FA-occupied" albumin is required, as this better describes IMA in patients with acute coronary syndrome. We also offer "oxidation modified albumin, OMA," which is conceptually different from the "FA-occupied" IMA, to describe modification of albumin in chronic disease associated with increased oxidative stress.Öğe Left ventricular diastolic function evaluated with tissue Doppler imaging in children with familial Mediterranean fever(SPRINGER LONDON LTD, 2009) Baysal, Tamer; Peru, Harun; Oran, Bulent; Sahin, Tahir Kemal; Koksal, Yavuz; Karaaslan, SevimThe aim of this study was to assess the left ventricular diastolic function using conventional echocardiography and tissue Doppler imaging in children with familial Mediterranean fever. This study included 29 (13 males and 16 females) patients and 30 healthy subjects as controls. Body mass index was calculated and arterial blood pressure was monitored. After an overnight fast, venous blood samples were taken and serum amyloid A protein, C-reactive protein, serum-fasting glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol, very low density lipoprotein cholesterol, and serum low-density lipoprotein cholesterol levels were measured. A complete 2-dimensional, M-mode, pulse wave Doppler, and pulse wave tissue Doppler echocardiographic examination was performed. There were no significant differences between the groups regarding age, body mass index values, systolic and diastolic blood pressures, heart rates, serum-fasting glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol, very low density lipoprotein cholesterol, and serum low-density lipoprotein cholesterol. Serum levels of inflammatory markers were higher in patients' group (C-reactive protein and serum amyloid A protein levels were 10.84 mg/dl, 22.32 mg/l in patients' group, respectively, and 4.11 mg/dl, 3.65 mg/l, respectively, in the healthy controls.) Peak mitral A wave, E and A wave ratio differed significantly in both groups. There were statistically significant differences regarding parameters observed by tissue Doppler imaging such as E'm, A'm, E'm, and A'm ratio between patients' group and controls. Tissue Doppler imaging provided additional information on left ventricular diastolic function. While systolic functions were in normal range, some of the diastolic function parameters were impaired in patients with familial Mediterranean fever during childhood.Öğe Myocardial Ventricular Noncompaction: Recent Literature Due to its Rarity in Childhood(GALENOS YAYINCILIK, 2015) Guvenc, Osman; Cimen, Derya; Arslan, Derya; Sivri, Mesut; Koplay, Mustafa; Oran, BulentMyocardial noncompaction is a rare form of congenital cardiomyopathy. The disorder represents an arrest of normal embryogenesis of myocardium in utero. It is characterized by deep trabecular structures anatomically and deep intratrabecular recesses. Congestive heart failure, thromboembolism and cardiac arrhythmias are main clinical findings. On the other hand patients may be asymptomatic. We describe a case of myocardial noncompaction presenting with decreased exercise capacity in our clinic. We would like to remind this rare disorder and search recent literatures.Öğe N-terminal-pro brain natriuretic peptide levels in children with allergic rhinitis(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2016) Artac, Hasibe; Vatansev, Husamettin; Cimen, Derya; Arslan, Derya; Kaya, Fatma; Kayis, Seyit Ali; Oran, BulentBackground/aim: Persistent upper airway obstruction may lead to increased pulmonary arterial pressure (PAP). The aim of this study was to evaluate N-terminal pro brain natriuretic peptide (NT-proBNP) concentrations and PAP values in children with allergic rhinitis. Materials and methods: Sixty-six patients with allergic rhinitis and 22 healthy children were prospectively enrolled in this study. Plasma NT-proBNP levels were measured at first admission and after treatment. Simultaneously, echocardiography was done to assess pulmonary arterial hypertension, and rhinitis symptom scores were recorded. Results: The median age of the study group was 9.0 (5.0. 17.0) years; 26 were female. PAP was found to be normal in all the patients. There was a negative correlation between age and NT-proBNP levels (r = -0.452, P < 0.01). Nasal blockage levels affected NT-proBNP levels mildly (P = 0.067). No significant difference between before and after nasal steroid treatment was observed in NT-proBNP levels. Conclusion: These results suggest that NT-proBNP level and PAP may not be affected in children with allergic rhinitis, and primarily this influence may be associated with the severity of nasal obstruction.Öğe Normal M mode values in healthy Turkish children(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2014) Oran, Bulent; Bodur, Abdurrahman Said; Arslan, Derya; Cimen, Derya; Guvenc, OsmanAim: Evaluation of cardiac structures requires a large study group for accurate data on normal values. The aim of the study was to obtain normal M mode echocardiographic values in a substantial sample of healthy term neonates and children to develop centile charts. Materials and methods: Data were obtained over 2 years from a single center in Turkey, from 1200 healthy infants and children aged 1 day to 17 years. Using echocardiographic investigation, measurements were obtained of the following: left ventricular dimension at end diastole and end systole; thickness of interventricular septum and posterior wall of the left ventricle; aortic and pulmonary root diameter; and left atrial dimension. The influence of systematic errors as statistical noise in this large sample was decreased using third-degree polynomial curves. Results: Measurements are presented graphically as curved lines of centiles with respect to body weight for healthy term neonates and children. The values showed a good correlation with body weight and allowed the construction of percentile curves (5%, 25%, 50%, 75%, and 95%). Higher values were observed in boys during adolescence. Conclusion: The presented charts and tables make it possible to judge the echocardiographic measurements of a particular patient as normal or abnormal.Öğe P-Wave Dispersion in Children With Acute Rheumatic Fever(SPRINGER, 2012) Kocaoglu, Celebi; Sert, Ahmet; Aypar, Ebru; Oran, Bulent; Odabas, Dursun; Arslan, Derya; Akin, FatihAs a new and simple electrocardiographic marker, P-wave dispersion is reported to be associated with inhomogeneous and discontinuous propagation of sinus impulses. The current study aimed to investigate P-wave dispersion in children with acute rheumatic fever. The study population consisted of 47 children with acute rheumatic fever (29 patients with carditis and 18 patients without carditis) and 31 healthy control subjects. Maximum and minimum P-wave durations were measured from the 12-lead surface electrocardiogram. The P-wave dispersion was calculated as the difference between maximum and minimum P-wave durations. The maximum P-wave duration and the P-wave dispersion of the patients with and without carditis were significantly greater than those of the control subjects. The P-wave dispersion of the patients with carditis was significantly greater than that of the patients without carditis. In conclusion, the P-wave dispersion was higher in the children with acute rheumatic fever than in the healthy control subjects.Öğe P-wave duration and dispersion in children with uncomplicated familial Mediterranean fever(TAYLOR & FRANCIS LTD, 2013) Arslan, Derya; Oran, Bulent; Yazilitas, Fatma; Peru, Harun; Cimen, Derya; Vatansev, HusamettinObjectives This was a prospective controlled study to determine the P-wave duration (Pdu) and P-wave dispersion (Pd) in patients with familial Mediterranean fever (FMF). Methods The study group consisted of 26 children with uncomplicated FMF and 25 age-and sex-matched healthy controls. We performed electrocardiography (ECG) with Doppler echocardiography on patients and controls. All participants underwent 12-lead electrocardiography under strict standards. Pdu and Pd were computed from a randomly selected beat and from an averaged beat constructed from 12 beats, included in a 10-s ECG. Results The left ventricle (LV) dimensions, LV ejection fraction (LVEF), and LV fractional shortening (LVFS) values, left atrium dimension, and aortic dimension were in normal range in both groups. There were significant differences between the groups regarding LV-isovolumic relaxation time (IRT), LV-isovolumic contraction time (ICT), right ventricle (RV)-ICT, RV-IRT, and Pd (all p < 0.0001). However, highly significant positive correlation was detected between LV-ICT, LV-IRT, RV-ICT, RV-IVT, C-reactive protein (CRP), and Pd (r = 0.505, p < 0.0001; r = 0.483, p < 0.0001; r = 0.433, p = 0.001; r = 0.421, p = 0.001; r = 0.452, p = 0.001; r = 0.478, p < 0.0001, respectively). Conclusions Uncomplicated FMF children who are continuously treated with colchicine and do not develop amyloidosis have abnormal atrial dispersion and therefore seemingly have an increased electrocardiographic risk of atrial fibrillation.
