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    The Preventive Effects of Different Doses of Glucomannan on Experimental Aflatoxicosis in Japanese Quails
    (FACTA-FUNDACIO ARNCO CIENCIA TECNOLOGIA AVICOLAS, 2017) Yavuz, O.; Ozdemir, O.; Ortatatli, M.; Atalay, B.; Hatipoglu, F.; Terzi, F.
    This experimental study was performed to investigate whether there is a protective effect of different doses of Glucomannan using against aflatoxicosis in Japanese quail, and pathological changes and relative organ weights were compared. In the experiment, 60 one-day old male Japanese quails were used as divided into six different groups. Experimental groups were designated as Control(C), aflatoxin(A), glucomannan(GM), 2-fold dose of glucomannan(2GM), aflatoxin+glucomannan(A+GM) and aflatoxin+2-fold dose of glucomannan(A+2GM). While control group quails fed the standard ration as ad libitum, other groups were fed with the administrations additionally to standard diet respectively; 2mg/kg of aflatoxin to group A, 1g/kg of glucomannan to group GM, 2g/kg of glucomannan to group 2GM, 2mg/kg of aflatoxin and 1g/kg glucomannan to group A+GM, 2mg/kg of aflatoxin and 2g/kg glucomannan to group A+2GM. All quails were euthanized at day 21 of the study and organs, (liver, spleen, kidney, thymus and bursa of Fabricius) were removed, weighed and subjected to routine histopathological procedures. Although any important macroscopic changes were not observed in the C, GM and 2GM groups, significant pathological changes were found in the groups of A, A+GM and A+2GM. In the A+GM group, the partial reduction in the severity of microscopic lesions were seen in liver, bursa of Fabricius, thymus and spleen, however a significant reduction in severity of lesions was noticed in A+2GM group. As a result of the study, 2g/kg of glucomannan has been found pathologically to be more effective than 1g/kg glucomannan in terms of the protection against aflatoxicosis by giving orally.
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    Use of aluminium hydroxide and calcium phosphate as delivery molecules for TGF-beta(1)
    (INDIAN VETERINARY JOURNAL, 2007) Ucan, U. S.; Yildirim, S.; Simsek, A.; Ortatatli, M.; Erganis, O.
    Transforming Growth Factor-beta(1) (TGF - beta(1))'s mitogenic activities have been documented to some extent in dentinogenesis and wound healing. However, TGF as a therapeutical agent has not been considered neither in veterinary nor in medical dentistry so far. In order to examine this, it is first necessary. to incorporate the cytokine to a slow delivery system and then to show its various effects on different types of cells. The present study was designed to evaluate the properties of two different adjuvants, aluminium hydroxide (AH) and calcium phosphate (CP), as delivery substances for recombinate human TGF-beta(1).