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    Antimicrobial and antiviral effects of essential oils from selected Umbelliferae and Labiatae plants and individual essential oil components
    (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2012) Orhan, Ilkay Erdogan; Ozcelik, Berrin; Kartal, Murat; Kan, Yuksel
    The essential oils obtained from Anethum graveolens, Foeniculum vulgare collected at fully-mature and flowering stages, Mentha piperita, Mentha spicata, Lavandula officinalis, Ocimum basilicum (green- and purple-leaf varieties), Origanum onites, O. vulgare, O. munitiflorum, O. majorana, Rosmarinus officinalis, Salvia officinalis, and Satureja cuneifolia, as well as the widely encountered components in essential oils (gamma-terpinene, 4-allylanisole, (-)-carvone, dihydrocarvone, D-limonene, (-)-phencone, cuminyl alcohol, cuminyl aldehyde, cuminol, trans-anethole, camphene, isoborneol, (-)-borneol, L-bornyl acetate, 2-decanol, 2-heptanol, methylheptane, farnesol, nerol, isopulegol, citral, citronellal, citronellol, geraniol, geranyl ester, linalool, linalyl oxide, linalyl ester, alpha-pinene, beta-pinene, piperitone, (-)-menthol, isomenthone, carvacrol, thymol, vanillin, and eugenol), were screened for their antiviral activity against Herpes simplex type-1 (HSV-1) and parainfluenza type-3 (PI-3). Cytotoxicity was expressed as cytopathogenic effect. Most of the oils and compounds displayed strong antiviral effects against HSV-1, ranging between 0.8 and 0.025 mu g mL(-1). However, the samples tested were less effective against PI-3, with results ranging between 1.6 and 0.2 mu g mL(-1). The essential oil of A. graveolens was the-most active. Most of the tested oils and compounds exhibited good antibacterial and antifungal effects.
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    In vitro antiviral activities under cytotoxic doses against herpes simples type-1 and parainfluensa-3 viruses of Cicer arietinum L. (Chickpea)
    (ACADEMIC JOURNALS, 2009) Kan, Asuman; Ozcelik, Berrin; Kartal, Murat
    The objective of this study was to evaluation antiviral activities of the extracts from the seed, fruit skin and aerial parts of ten registered varieties Cicer arietinum (Chickpea) against Herpes simplex type 1 (HSV-1) and Parainfluenza-3 (PI-3) viruses. Madin-Darby Bovine Kidney and Vero cell lines were employed for antiviral assessment of the Cicer arientinum L. extracts, in which acyclovir for HSV-1 and oseltamivir for PI-3 were tested as reference drugs. This is the first report showing that C. arietinum seed extracts of Cse-5 possesses significant antiviral activity both of DNA (32 - 4 mu g ml(-1)) and RNA (32 16 mu g ml(-1)) viruses compared to the fruit skin and aerial part extracts as well as the controls. Besides, the extracts of fruit skin (Cfs-4) and aerial parts (Cap-5) showed remarkable activity against DNA viruses at 32 - 1 mu g ml-(1).
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    Inhibitory Effects of Various Essential Oils and Individual Components against Extended-Spectrum Beta-Lactamase (ESBL) Produced by Klebsiella pneumoniae and Their Chemical Compositions
    (WILEY, 2011) Orhan, Ilkay Erdogan; Ozcelik, Berrin; Kan, Yuksel; Kartal, Murat
    In the current study, in vitro inhibitory activity of several essential oils obtained from the cultivated plants, Foeniculum vulgare, Mentha piperita and M. spicata, Ocimum basilicum, Origanum majorana, O. onites, O. vulgare, Satureja cuneifolia, and a number of individual essential oil components of terpene and aromatic types were screened against 10 isolated strains of Klebsiella pneumoniae producing extended-spectrum beta-lactamase (ESBL) enzyme, which makes this microorganism quite resistant against the antibiotics: trimetoprime-sulfametoksazol, sulbactam-ampicilin, clavulonate-amoxicilin, ceftriaxon, cefepime, imipenem, ceftazidime, tobramicine, gentamisine, ofloxacin, and ciprofloksasin. All of the essential oils and the components exerted a remarkable inhibition ranging between 32 and 64 mu g/mL against all of these strains as strong as the references (ampicilin and oflaxocin) inhibiting at 32 mu g/mL. Besides, chemical compositions of the essential oils were elucidated by gas chromatography-mass spectrometry (GC-MS). The essential oils and the pure components widely found in essential oils screened herein have shown remarkable inhibition against ESBL-producing K. pneumoniae strains, which leads to the suggestion that they may be used as food preservatives for this purpose.