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Öğe Effect of fixed appliances on oral malodor(MOSBY-ELSEVIER, 2011) Babacan, Hasan; Sokucu, Oral; Marakoglu, Ismail; Ozdemir, Hakan; Nalcaci, RuhiIntroduction: The objective of this study was to evaluate the effect of fixed appliances on oral malodor. Methods: Forty-one patients participated in this study. They were randomized into 2 groups: treated with fixed orthodontic appliances and untreated controls. Oral malodor measurements and the gingival and plaque indexes were recorded in each group by same periodontist. Measurements were taken from the study group before bonding, 1 week after bonding, and 4 weeks after bonding. The control group's measurements were made at the same time. Results: Oral malodor and the gingival and plaque indexes were significantly increased 1 week after bonding (P < 0.05). Oral malodor was increased at 4 weeks after bonding (P > 0.05). The comparison of the groups showed differences 1 week and 4 weeks after bonding. Conclusions: The oral malodor reached the critical level during fixed orthodontic treatment. Oral malodor could indicate a need to evaluate oral health and remind patients of the importance of maintaining ideal oral hygiene. (Am J Orthod Dentofacial Orthop 2011;139:351-5)Öğe In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate(CHURCHILL LIVINGSTONE, 2013) Tunali, Mustafa; Ozdemir, Hakan; Kucukodaci, Zafer; Akman, Serhan; Firatli, ErhanWe have developed a new, titanium-prepared, platelet-rich fibrin (T-PRF) together with the protocol for forming it, which is based on the hypothesis that titanium tubes may be more effective at activating platelets than the glass tubes used by Chouckroun in his platelet-rich fibrin (PRF) method. The aim of this study was to find a suitable animal model in which to evaluate the method and to investigate the efficacy of T-PRF for wound healing. Blood samples from 6 rabbits were used to confirm the protocol for formation of T-PRF. We evaluated T-PRF or T-PRF-like clots morphologically using scanning electron microscopy (EM). Blood samples from 5 rabbits were used to develop an experiment in which to evaluate the effects of T-PRF on wound healing. The mucoperiosteal flaps were filled with autologous T-PRF membranes from the vestibule in the anterior mandibular regions. Samples collected from the surgical sites were stained with haematoxylin and eosin. We found a mature fibrin network in T-PRF clots that had been centrifuged for 15 min at 3500 rpm and, 15 days after placement of the membrane, we found newly-forming connective tissue and islets of bony tissue in the T-PRF membrane. These results show that T-PRF could induce the formation of new bone with new connective tissue in a rabbit model of wound healing within 30 days of treatment. Published by Elsevier Ltd. on behalf of The British Association of Oral and Maxillofacial Surgeons.Öğe A Novel Platelet Concentrate: Titanium-Prepared Platelet-Rich Fibrin(HINDAWI LTD, 2014) Tunali, Mustafa; Ozdemir, Hakan; Kucukodaci, Zafer; Akman, Serhan; Yaprak, Emre; Toker, Hulya; Firatli, ErhanWe developed a new product called titanium-prepared platelet-rich fibrin (T-PRF). The T-PRF method is based on the hypothesis that titanium may be more effective in activating platelets than the silica activators used with glass tubes in Chouckroun's leukocyte- and platelet-rich fibrin (L-PRF) method. In this study, we aimed to define the structural characteristics of T-PRF and compare it with L-PRF. Blood samples were collected from 10 healthy male volunteers. The blood samples were drawn using a syringe. Nine milliliters was transferred to a dry glass tube, and 9 mL was transferred to a titanium tube. Half of each clot (i.e., the blood that was clotted using T-PRF or L-PRF) was processed with a scanning electron microscope (SEM). The other half of each clot was processed for fluorescence microscopy analysis and light microscopy analysis. The T-PRF samples seemed to have a highly organized network with continuous integrity compared to the other L-PRF samples. Histomorphometric analysis showed that T-PRF fibrin network covers larger area than L-PRF fibrin network; also fibrin seemed thicker in the T-PRF samples. This is the first human study to define T-PRF as an autogenous leukocyte-and platelet-rich fibrin product. The platelet activation by titanium seems to offer some high characteristics to T-PRF.