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Öğe Alternate day therapy in patients with combined hiperlipidemia(OXFORD UNIV PRESS, 2007) Ozdemir, K.; Duzenli, M. A.; Aygul, N.; Gurbilek, M.; Karabag, T.[Abstract not Available]Öğe Atorvastatin did not prevent recurrence of atrial fibrillation in addition to antiarrhythmic therapy after electrical cardioversion(OXFORD UNIV PRESS, 2007) Can, I.; Demir, K.; Ozdemir, K.; Altunkeser, B. B.; Tokac, M.; Gok, H.[Abstract not Available]Öğe Effect of increasing doses of aspirin on aspirin resistance in patients with diabetes mellitus(OXFORD UNIV PRESS, 2007) Dogan, Y.; Duzenli, M. A.; Ozdemir, K.; Aygul, N.; Soylu, A.; Tokac, M.; Aribas, A.[Abstract not Available]Öğe The effects of hormone replacement therapy on myocardial performance in early postmenopausal women(TAYLOR & FRANCIS LTD, 2010) Duzenli, M. A.; Ozdemir, K.; Sokmen, A.; Gezginc, K.; Soylu, A.; Celik, C.; Altunkeser, B. B.Method In a prospective, controlled study, 60 healthy postmenopausal women were assigned to two groups (32 in the HRT group and 28 in the control group). After conventional echocardiographic parameters were measured, tissue Doppler echocardiography recordings were obtained from the mitral and tricuspid annulus. Systolic myocardial velocity (Sm), early and late diastolic myocardial velocities (Em and Am) and time intervals were measured and MPI was calculated. Then the symptom-limited exercise stress test using the Bruce protocol was performed. After 3 and 6 months of HRT (oral 0.625 mg conjugated estrogen + 2.5 mg medroxyprogesterone acetate/day), the same examinations were repeated. The effects of HRT on myocardial velocities, MPI and exercise time were evaluated at the 3rd and 6th months. Results The parameters of the control group remained statistically unchanged during the study. HRT did not have any effect on segmental and mean left ventricular (LV) Sm or right ventricular (RV) Sm. However, LV Em/Am and RV Em/Am ratios significantly increased at the 6th month of HRT, and LV and RV MPI values were observed to decrease significantly as compared to basal values. Additionally, a significant increase was observed in exercise duration and metabolic equivalent values after 3 months of HRT, and this increase continued at the 6th month as well. The favorable changes in all parameters in the HRT group were significantly different from those of the control group. Conclusion Data obtained in this study suggest that HRT is not only effective for treating menopausal complaints but also increases cardiovascular performance by improving especially diastolic functions in early postmenopausal women.Öğe The effects of hormone replacement therapy on the myocardial velocities and myocardial performance index(OXFORD UNIV PRESS, 2007) Duzenli, M. A.; Ozdemir, K.; Sokmen, A.; Soylu, A.; Gezginc, K.; Celik, C.; Tokac, M.[Abstract not Available]Öğe The effects of menopause on the myocardial velocities and myocardial performance index(OXFORD UNIV PRESS, 2007) Duzenli, M. A.; Ozdemir, K.; Sokmen, A.; Soylu, A.; Aygul, N.; Tokac, M.[Abstract not Available]Öğe Evaluation of the acute effect of palonosetron on transmural dispersion of myocardial repolarization(VERDUCI PUBLISHER, 2012) Dogan, U.; Yavas, G.; Tekinalp, M.; Yavas, C.; Ata, O. Y.; Ozdemir, K.Background: 5-hydroxytryptamine receptor type-3 (5-HT3) antagonists are widely used for prophylaxis of chemotherapy-induced nausea and vomiting (CINV) and regarded to have a high safety profile. However, several electrocardiographic changes and cardiac arrhythmias have been reported due to administration of 5-HT3 antagonists. Only prolongation of QT interval has been investigated as an index of potential for life-threatening arrhythmias in adult patients using 5-HT3 antagonists. Recently, increase in transmural dispersion of repolarization (TDR) has been proposed as a more reliable determinant of arrhythmogenic potential. Aim: To assess the effects of palonosetron, a second-generation 5-HT3 antagonist, on the T-wave peak to T-wave end (TpTe) interval which has been proposed as a reliable index of spatial TDR. Patients and Methods: A total of 50 consecutive cancer patients (aged: 57 +/- 12 years) who were scheduled to receive emetogenic chemotherapy were included to the study. Baseline12-lead electrocardiography (ECG) recordings were obtained. Then, all patients received 8 mg intravenous dexamethasone followed by a single dose of 0.25 mg intravenous palonosetron administered over 30 seconds. A second ECG was performed 30 minutes after the administration of palonosetron. Indices of cardiac repolarization and TOR before and after the administration of palonosetron were compared. Results: In comparison with baseline there was no statistically significant change in any of the heart rate-corrected parameters, including QT(c) (lead V-5), QT(maxc), QT(minc), QT(cd), TpTe (V-5), TpTe(max), TpTe(min), TpTe(d) and TpTe/QT (V-5). Conclusions: Palonosetron does not have any significant effect on QT(c) and TpTe intervals. It might be the drug of choice for prophylaxis of CINV in cancer patients receiving chemotherapy with known cardiotoxic potential or who have pre-existing cardiac disease that predispose them to drug-induced arrhythmias.Öğe Relationship between blood glucose level and left ventricular performance in patients with diabetes mellitus?(OXFORD UNIV PRESS, 2005) Yazici, M.; Ozin, B.; Ozdemir, K.; Altunkeser, B.; Yazici, R.; Kayrak, M.[Abstract not Available]