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    Evaluation of HLA-A, -B, -Cw, and -DRB1 alleles frequency in Turkish patients with nasal polyposis
    (SAGE PUBLICATIONS LTD, 2008) Keles, Bahar; Cora, Tuelin; Acar, Hasan; Arbag, Hamdi; Inan, Ziya; Ozturk, Kayhan; Ozer, Bedri
    OBJECTIVE: To evaluate whether there is a relationship between HLA-A, -B, -Cw, and -DRB1 alleles and developing nasal polyposis (NP). STUDY DESIGN: Data from 66 patients with NP were compared with data from 100 healthy randomly selected controls. Asthma, ASA (acetylsalicylic acid) triad, polyp score, and previous sinonasal surgery were also recorded. SUBJECTS AND METHODS: Genotyping of the HLA-A, -B, -Cw, and -DRB1 alleles were performed with polymerase chain reaction (PCR) with the sequence-specific primer (SSP) method. Data were analyzed by using a Pearson chi(2) test. RESULTS: The HLA-B*07 and -Cw*12 alleles were found to be significantly higher in the NP patients compared with the control group, whereas the HLA-B*57 and HLA-Cw*04 alleles were significantly lower (P < 0.05). The HLA-A*24, HLA-Cw*12, and HLA-DRB1*04 alleles were determined to be significantly higher in the NP patients with asthma and ASA triad (P < 0.05). CONCLUSIONS: Our results show that some of the HLA alleles seem to be associated with the genetic susceptibility to develop NP in the Turkish population. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.
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    Ghrelin levels in children with adenoid or chronic tonsil hypertrophies before and after surgery
    (ELSEVIER IRELAND LTD, 2009) Koc, Sema; Ozturk, Kayhan; Buyukbas, Sadik; Kocabas, Volkan; Ozer, Bedri; Kara, Medine
    Objective: We aimed to evaluate the ghrelin levels in the children with adenoid or tonsil hyperthrophies. Methods: The Study included 27 children (17 boys and 10 girls). Mean age was 6.9 +/- 3.5 years, ranging from 3 to 16. Ghrelin levels in the patients and their weight and height measurements were evaluated before surgery and after 3 months later of the operation. Results: While 18 (67%) children were operated for adenoid hypertrophy, 9 (33%) children were operated for adenoid and tonsil hypertrophy. it was found that postoperative ghrelin levels were significantly decreased whereas weight and BMI scores were significantly increased (p < 0.01). A weak correlation was observed between preoperative ghrelin and weight (r = -0.29), This negative Correlation became more profound at the postoperative 3rd month examination (r = 0.85) (p < 0.01). Conclusions: The present Study showed that the surgical treatment provides positive contributions on the growing of children with adenoid and tonsil hypertrophies. The ghrelin levels were significantly decreased at the postoperative period in the children, and a negative relationship was observed between the ghrelin levels and the weight, These findings Suggest that blood ghrelin levels may be useful as a parameter for following the development of the children. (c) 2009 Elsevier Ireland Ltd. All rights reserved.
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    Relation of glutathione S-transferase genotypes (GSTM1 and GSTT1) to laryngeal squamous cell carcinoma risk
    (ELSEVIER SCIENCE INC, 2006) Acar, Hasan; Ozturk, Kayhan; Muslumanoglu, M. Hamza; Yildirim, M. Selman; Cora, Tulin; Cilingir, Oguz; Ozer, Bedri
    The purpose of the present study was to investigate GSTM1 and GSTT1 genotypes by using multiplex polymerase chain reaction (PCR) in patients with laryngeal squamous cell carcinoma (LSCC). The genotypes of 110 patients with LSCC and of 197 healthy subjects as the control group were determined by PCR analysis for GSTM1 and GSTT1 genes. Results showed that frequencies of GSTM1-null, GSTT1-null, and both GSTs-null genotypes were 51.8, 30, and 16.4%, respectively, in the patients with LSCC and 37.6, 15.7, and 5.6% in the control group. There was a significant difference between the genotype distributions of all GSTs in patients and in control groups (P < 0.05). The results support the hypothesis that null genotypes of GSTM1 and GSTT1 can reduce detoxification capacity of GSTs as members of the xenobiotic enzyme system. GSTM1-null, GSTT1-null, and both GSTs-null genotypes were more common in the patients with LSCC than in the control group. Patients with both GSTs-null genotypes had the highest risk for supraglottic LSCC in the early period, even if they were light-to-medium smokers. Investigation and determination of the genetic basis of LSCC may contribute to detection of risk groups and to prevent LSCC in the population. (c) 2006 Elsevier Inc. All rights reserved.