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Öğe Determination of operation time in colorectal diseases: Preoperative chemotherapy application(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005) Sahin, M; Erikoglu, M; Ozer, S; Tekin, A; Boz, S; Golcuk, M; Avunduk, MCBackground. Our aim was to determine the time it takes for wound healing to return to normal in cases where patients have undergone preoperative chemotherapy. Materials and methods. Eighty-four Wistar-albino rats were included in the study. Twelve of them were placed in the control group (Group 1), with no further drug administration. Another 12 rats were placed in a sham group (Group 11) and were peritoneally injected with 1 cc of isotonic saline solution 5 days a month, for a period of 6 months. The remaining 60 rats were placed in five chemotherapy groups (Groups III-VII) and were administered 20 mg/kg 5-fluorouracil through peritoneal injection, 5 days a month for a period of 6 months. At the end of the sixth cure, 12 rats from the control (Group 1), sham (Group II), and chemotherapy groups (Group III) were operated on, and an intestinal transsection. was applied to the rectosigmoid junction, followed by one-by-one anastomosis using 5/0 vicryl. Other groups (Groups IV-VI) with chemotherapy treatment were operated on at 1-week intervals and subjected to the same procedure. The subjects were reoperated on on the eleventh day. A full-layer 4 x 4 cm piece was removed from the abdominal wall containing the previous incision line at the middle, for tensile strength pressure measurements. In addition, a 4 cm colon segment was removed for bursting pressure measurements. Plasma albumin and tissue hydroxyproline levels were measured, and fibroblast numbers were counted in the sections prepared from the abdominal wall. Results. The control and sham groups were found to be similar to each other with respect to all parameters measured (P > 0.05). Significant reductions were observed in all parameters in the early chemotherapy groups compared with the control and sham groups (P <0.05). All parameters measured in Groups V, VI, and VII were found to be similar to those in the control and sham groups (P <0.05). Conclusion. Wound healing is impaired in rats with chemotherapy, but following the second week after the chemotherapy, disrupted parameters return to their normal levels. (C) 2005 Elsevier Inc. All rights reserved.Öğe Effects of gender on the severity of sepsis(SPRINGER, 2005) Erikoglu, M; Sahin, M; Ozer, S; Avunduk, MCPurpose. To investigate the differences between male and female rats and the effects of sex hormones on tissue changes in the lung and liver in a sepsis model. Methods. Sixty Sprague-Dawley rats were divided into six groups of ten. Groups 1 and 2 were the control male and female groups, respectively, subjected only to sepsis; groups 3 and 4 were the male and female groups, respectively, subjected to sepsis, then given 0.04 mg/kg estrogen + progesterone (E-P) intramuscularly (i.m.); and groups 5 and 6 were the male and female groups, respectively, subjected to sepsis, then given 0.5 mg/kg testosterone ( T) i.m. The rats were killed and the histopathological changes in the lung and liver were examined, and plasma endotoxin levels were measured. Results. Histopathological examination revealed less congestion, portal inflammation, and focal necrosis of the liver, and less congestion, edema, and emphysematous and inflammatory changes in the lung in the E-P groups than in the other groups. Moreover, signs of systemic endotoxemia in plasma were proportionally less in the female rats and in the E-P groups than in the male rats and the T groups. Conclusion. Female rats subjected to sepsis showed less liver and lung tissue damage and less systemic endotoxemia than male rats, because of the effects of female sex hormones.