Yazar "Ozergin, U" seçeneğine göre listele
Listeleniyor 1 - 6 / 6
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe The cerebroprotective effects of pentoxifylline and aprotinin during cardiopulmonary bypass in dogs(ARNOLD, HODDER HEADLINE PLC, 2004) Durgut, K; Hosgor, K; Gormus, N; Ozergin, U; Solak, HObjective: The purpose of this study was to investigate the cerebroprotective effects of pentoxifylline (PNX) and aprotinin in dogs using cardiopulmonary bypass (CPB). Materials and methods: Eighteen clinically healthy dogs were divided into three groups: Group 1 ( control, n = 6), Group 2 (PNX, n = 6), and Group 3 (aprotinin, n = 6). PNX was administered at a dose of 300 mg/day in Group 2 three days before the operation and during the operation. Half a million IU aprotinin were added to the prime solution and 500 000 IU were transfused via a central venous jugular catheter preoperatively in Group 3. Blood samples were taken from the central jugular vein before and after CPB and interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and S100beta protein were measured. Gliosis was investigated histopathologically in cerebral cortex biopsy samples under light microscopy. Results: The preoperative results of IL-6, TNF-alpha, and S100beta protein values were found to be significantly higher (p < 0.001) when compared with postoperative values. This significant difference was observed in the same parameters between Groups 1 and 2, and 1 and 3 (p < 0.001). There was no significant difference between Groups 2 and 3. Comparison between pre- and postoperative levels of IL-6 and TNF-alpha for Group 2 and Group 3 revealed statistically significant differences (p < 0.001), whereas S100β protein levels did not. Histopathological examinations showed significant differences between the control group and PNX and aprotinin, and between aprotinin and PNX groups (p < 0.001). Conclusion: PNX and aprotinin might be useful in order to reduce postoperative cerebral damage in patients undergoing cardiac surgery with CPB.Öğe Lemierre's syndrome associated with septic pulmonary embolism: A case report(SPRINGER-VERLAG, 2004) Gormus, N; Durgut, K; Ozergin, U; Odev, K; Solak, HAn 18-year-old female patient suffering from a painful right-sided neck mass was admitted to our emergency service. Computed tomography of the neck revealed thrombosis of the right internal jugular vein. Computed tomography of the chest indicated septic pulmonary emboli in both lungs. Blood and oropharyngeal cultures showed proteus that was sensitive to cefepime and amicasin. Chemotherapy was administered for 12 days, however, her complaints continued with fulminant progression. An urgent decompression and excessive debridement were performed. Although Lemierre syndrome is a well-known cause of internal jugular vein thrombosis, association with proteus culture is very rare.Öğe The mechanisms of the direct vascular effects of fentanyl on isolated human saphenous veins in vitro(W B SAUNDERS CO-ELSEVIER INC, 2005) Sahin, AE; Duman, A; Atalik, EK; Ogun, CO; Sahin, TK; Erol, A; Ozergin, UObjective: The purpose of this study was to determine the mechanism of the direct effects of fentanyl on human veins in vitro. Design: In vitro, prospective with repeated measures. Setting: University research laboratory. Interventions: Dose-response curves were obtained for cumulative doses of fentanyl (10(-9)-10(-5) mol/L) on saphenous vein strips precontracted with (10(-6) mol/L) 5-hydroxytryptamine incubated with either naloxone (10(-4) mol/L), N omega-nitroL-arginine-methyl ester (L-NAME) (10(-4) mol/L), indomethacin (10(-5) mol/L), glibenclamide (10-4 mol/L), tetraethylammonium (10(-4) mol/L), or ouabain (10(-5) mol/L). Vein strips were also exposed to a Ca++-free solution and 0.1 mmol/L of ethylene glycol-bis-(b-aminoethylether) N,N '-tetraacetic acid; 5-hydroxytryptamine (10(-6) mol/L) was added to the bath before cumulative Ca++ (10(-4)-10(-2) mol/L). The same procedure was repeated in the presence of fentanyl (10-6, 3 x 10-6, or 10-5 mol/L) (p < 0.05 = significant). Measurements and Main Results: Preincubation of vein strips with naloxone, L-NAME, or indomethacin did not influence the relaxant responses to fentanyl (p > 0.05). Tetraethylammonium, glibenclamide, and ouabain reduced the relaxation response to fentanyl (p < 0.05). A stepwise increase in tension was recorded with cumulative doses of Ca++ (p < 0.05). Conclusions: The present results show that fentanyl causes vasodilatation via both endothelium- and opioid receptor-independent mechanisms in the human saphenous vein. The relaxant effects of fentanyl are probably via activation of K+ channel and Na+K+-adenosine trisphosphatase and inhibition of Ca++ channel. (c) 2005 Elsevier Inc. All rights reserved.Öğe Suppurated mediastinal and cardiac echinococcosis: Report of a case(SPRINGER, 2005) Gormus, N; Durgut, K; Ozergin, U; Solak, HWe herein report the case of a suppurated mediastinal and cardiac hydatid cyst which occurred after the initial treatment of the patient for a primary mediastinal hydatid cyst in a radiology department. Both extracorporeal circulation and total circulatory arrest were used during the operation. We believe that surgery is the only feasible treatment for hydatid cysts located in the mediastinum, and surgery should be urgently performed whenever a possible rupture is suspected in order to avoid a possible anaphylactic reaction, mediastinal suppurations leading to serious complications, and growth into the pleural cavity.Öğe Supravalvular aortic stenosis without Williams syndrome(GEORG THIEME VERLAG KG, 1996) Ozergin, U; Sunam, GS; Yeniterzi, M; Yuksek, T; Solak, T; Solak, HIn this article, the case of a 30-years-old female patient with supravalvular aortic stenosis is reported. Her clinical picture was otherwise completely different from Williams syndrome. Since supravalvular aortic stenosis is rarely seen, its forms are discussed and it is concluded that supravalvular aortic stenosis can be present without Williams syndrome.Öğe Vena cubiti media for creation of a loop-shaped arteriovenous fistula at the elbow region(SPRINGER, 2004) Gormus, N; Ozergin, U; Ozpinar, C; Solak, HHemodialysis access is one of the major routes, for patients who need long-term hemodialysis. In this report, we tried a new secondary arteriovenous fistula technique. Between January 2000 and June 2003, hemodialysis access was created in more than 650 patients with end-stage renal failure at our institution. In 15 cases a loop-shaped hemodialysis access was created between the brachial artery and vena cubiti media as a second choice. The youngest patient was 12 years old, whereas the oldest was 75. The mean follow-up period (+/-SD) for these patients was 10.4+/-2.53 months. Twelve patients are still using these fistulas successfully for hemodialysis (86.6%), whereas one patient died 7 months after the operation (6.7%). In one patient, the arteriovenous fistula failed 6 months after the operation (6.7%). Thrombosis due to hypotension occured in two cases (13.3%) and this was resolved by simple thrombectomy. One patient had an aneurysm over the vena cubiti media (6.6%). None of the patients had an infection. These results suggest that an end-to-side anastomosis between the brachial artery and, vena cubiti media can be used as a second choice for hemodialysis access in patients with end-stage renal disease.
