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    Association of polymorphisms in APOE, p53, and p21 with primary open-angle glaucoma in Turkish patients
    (MOLECULAR VISION, 2009) Saglar, E.; Yucel, D.; Bozkurt, B.; Ozgul, R. K.; Irkec, M.; Ogus, A.
    Purpose: To investigate the association between Apolipoprotein E (APOE), tumor suppressor protein p53 (p53), and cyclin-dependent kinase inhibitor 1A (p21) genes and primary open-angle glaucoma (POAG) in a cohort of Turkish subjects. Methods: Seventy-five POAG patients (49 women, 26 men) and 119 healthy subjects (67 women, 52 men) were genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Allele and genotype frequencies between healthy subjects and glaucoma patients were compared by the chi(2) test, and intraocular pressure (IOP), cup/disc ratio (C/D) and visual field indices (MD and PSD) were compared among different APOE, p53, and p21 genotypes in POAG group. A p value <0.05 was considered as statistically significant. Results: The mean ages were 63.8 +/- 9.5 and 61.8 +/- 10.2 years in POAG and control groups, respectively (p=0.18). There were no significant differences in the distribution of APOE, p53, and p21 genotypes between the healthy subjects and POAG patients (p=0.38, p=0.12, and p=0.2, respectively). There were no significant differences in maximum IOP, MD, and PSD values among different groups of p53 and p21 genotypes (p>0.05). POAG subjects with the epsilon 2 epsilon 3 genotype had a worse PSD value (median=2.2) than those with the epsilon 3 epsilon 4 genotype (median=1.77; p=0.01) and POAG subjects with the epsilon 3 epsilon 3 genotype had worse MD and PSD values (median=-7.4 and 3.4, respectively) than those with the epsilon 3 epsilon 4 genotype (median=-4.1 and 1.77, respectively; p=0.034 and 0.028, respectively). Conclusions: Our study found no link between polymorphisms in APOE, p53, and p21 genes and POAG in Turkish patients, although a larger sample is required to elucidate the role of these polymorphisms in the pathogenesis and course of glaucoma.