Yazar "Ozkagnici, Ahmet" seçeneğine göre listele
Listeleniyor 1 - 7 / 7
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Assessment of Macula and Retinal Nerve Fiber Layer Thickness with Optical Coherence Tomography in Myopia(ORTADOGU AD PRES & PUBL CO, 2012) Ozkagnici, Ahmet; Tokgoz, MineObjective: In the study, analysis of retina structure with optical coherence tomography (OCT) in emetropic and myopic cases was aimed. Material and Methods: The study group included a total of 224 cases (118 females, 106 males). Cases were divided into four groups: between 0.00/-0.75 D (first group=control group), between -1.00/-3.00 D (second group), between -3.25/-6.00 D (third group) and between -6.25/-12.00 D, according to their refractive error. Thickness of retinal nerve fiber layer (RNFL) and macula was measured using OCT. Results: While an increase was detected in foveal thickness and volume in the highly myopic group, a reduction was found in RNFL thickness of all areas except temporal area. Total macular volume, outer macular thickness and volume were also reduced. The highest thinning of RNFL in highly myopic cases was in 13.1% in superior and 18.6% in nasal thickness. There was a weak correlation between RNFL thickness, macular thickness and volume values and axial length/spheric equivalent. Conclusion: Assessment of especially nasal and superior quadrant thickness in RNFL is crucial in highly myopics. Distance between foveal pit and parafoveolar tip is inversely proportional with myopia, in other words, increase in degree of myopia causes macular area to become flatter.Öğe Bilateral rhegmatogenous retinal detachment repaired with simultaneous bilateral pneumatic retinopexy(CANADIAN OPHTHAL SOC, 2009) Keimoglu, Hurkan; Ozkagnici, Ahmet; Okudan, Suleyman[Abstract not Available]Öğe Evaluation of aneuploidy frequency for chromosomes 6 and 17 in eyelid tumours using the FISH technique(WILEY, 2007) Ozkagnici, Ahmet; Acar, Hasan; Zengin, Nazmi; Okudan, SuleymanAlthough basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are very common skin tumours, the incidence of chromosome aneuploidy with regard to the eyelid has not been investigated. We aimed to find the frequency of chromosome 6 and 17 aneuploidies in eyelid tumours' interphase nuclei with fluorescence in situ hybridization (I-FISH) with chromosome specific DNA probes. I-FISH with chromosome 6 and 17 centromere specific DNA probes was used in the eyelids of 10 patients with BCC or SCC and the peripheral blood cells of 10 healthy donors as controls. The frequency of chromosome 6 and 17 aneuploidies was significantly higher in 7 out of 10 patients and 5 out of 10 patients, respectively, than in controls, indicating a higher frequency of aneuploidy in BCC than in SCC of the eyelid. Distribution of hybridization signals for chromosome 6 and 17 was wide ranging, indicating heterogeneity of cell populations with aneuploidy between patients. These findings indicate that acquisition of chromosome aneuploidies in eyelid tumours may have an important pathogenic role in both BCC and SCC of the eyelid area. (c) 2006 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.Öğe Evaluation of Retinal Nerve Fiber Layer Thickness in Patients With Anisometropic and Strabismic Amblyopia Using Optical Coherence Tomography(SLACK INC, 2013) Ersan, Ismail; Zengin, Nazmi; Bozkurt, Banu; Ozkagnici, AhmetPurpose: To evaluate the retinal nerve fiber layer (RNFL) thickness of eyes with amblyopia using optical coherence tomography (OCT). Methods: RNFL thickness measurements obtained by time-domain OCT of amblyopic eyes of patients with strabismus (35 patients) and patients with anisometropia (30 patients) were compared with their fellow eyes and age-and gender-matched healthy eyes (40 participants). RNFL thickness values of the groups were also compared and the correlation between RNFL thickness and refraction was evaluated. Results: In the strabismic and anisometropic groups, there were no statistically significant differences in average RNFL thickness between amblyopic eyes and their fellow eyes (P > .05). Temporal RNFL quadrant in the hypermetropic anisometropic group, and superior RNFL quadrant in the myopic anisometropic group were significantly thinner in amblyopic eyes compared to their fellow eyes (P < .05). RNFL thickness did not differ between strabismic amblyopic, anisometropic amblyopic, and control eyes (P > .05). In the anisometropic group, a significant correlation was found between mean RNFL thickness and refraction (P < .05). Conclusion: Amblyopia is not associated with a decrease in RNFL thickness in strabismic or anisometropic amblyopia. In the anisometropic group, the inter-eye differences in RNFL thickness parameters seemed to be related to the refraction differences between the amblyopic eyes and their fellow eyes. [J Pediatr Ophthalmol Strabismus 2013;50:113-117.]Öğe Evaluation of Retinal Nerve Fiber Layer Thickness with Optical Coherence Tomography in Type 1 Diabetes Mellitus Patients(ORTADOGU AD PRES & PUBL CO, 2011) Gonul, Saban; Ozkagnici, Ahmet; Ozturk, Banu Turgut; Kerimoglu, Hurkan; Sahin, AlparslanObjective: To evaluate retinal nerve fiber layer (RNFL) thickness changes of type 1 diabetes mellitus (DM) patients with and without diabetic retinopathy (DR). Material and Methods: One hundred-eighteen patients with type 1 DM and 49 age-matched control subjects were enrolled in the study. Ninety eight of 118 diabetic patients with DR were assigned as group 1 and the remaining 20 patients without DR were labeled as group 20 (n = 98). The RNFL thickness of all subjects were measured using optical coherence tomography (OCT). Results: The study included 118 type 1 DM patients with a mean age of 18.77 +/- 8.80 years. The mean age of 49 subjects in the control group was 18.71 +/- 5.72 (range 7-40) years. The mean RNFL thickness was 103.79 +/- 6.45 mu m in the control group, 100.00 +/- 11.93 mu m in group 1 and 85.59 +/- 19.81 mu m in group 2. The decrease in group 2 was found statistically significant (p < 0.001). The mean RNFL thickness in the superior, nasal, inferior and temporal quadrants were less in group 1 compared to controls, however this data was not statistically significant (p = 0.274, p = 0.149, p = 0326, p = 0783, respectively). In group 2, the RNFL thickness revealed a statistically significant decrease in all quadrants (p < 0.001) except temporal quadrant (p = 0.396). The mean duration of DM was significantly longer in group 2 (153.80 +/- 70.35) compared to group 1(60.76 +/- 50.41 months) (p < 0.001). However, there was no correlation between the RNFL thickness and the duration of DM. Conclusion: The RNFL thickness of patients with type 1 DM was found less compared to control subjects. This was more prominent in patients with established retinopathy (group 2). These findings suggested that the RNFL thickness measurement with the aid of OCT may be used as an adjunctive diagnostic tool for early diagnosis of DR.Öğe In vivo corneal confocal microscopic analysis " in patients with keratoconus(IJO PRESS, 2015) Bitirgen, Gulfidan; Ozkagnici, Ahmet; Bozkurt, Banu; Malik, Rayaz A.AIM: To quantify corneal ultrastructure using laser scanning in vivo confocal microscopy (IVCM) in patients with keratoconus and control subjects. METHODS: Unscarred corneas of 78 keratoconic subjects without a history of contact lens use and 36 age-matched control subjects were evaluated with slit-lamp examination (SLE), corneal topography and laser scanning IVCM. One eye was randomly chosen for analysis. Anterior and posterior stromal keratocyte, endothelial cell and basal epithelial cell densities and sub-basal nerve structure were evaluated. RESULTS: IVCM qualitatively demonstrated enlarged basal epithelial cells, structural changes in sub -basal and stromal nerve fibers, abnormal stromal keratocytes and keratocyte nuclei, and pleomorphism and enlargement of endothelial cells. Compared with control subjects, significant reductions in basal epithelial cell density (5817 +/- 306 cells/mm(2) vs 4802 +/- 508 cells/mm(2), P<0.001), anterior stromal keratocyte density (800 +/- 111 cells/mm(2) vs 555 +/- 115 cells/mm(2), P<0.001), posterior stromal keratocyte density (333 +/- 34 cells/mm(2) vs 270 +/- 47 cells/mm(2), P<0.001), endothelial cell density (2875 +/- 223 cells/mm(2) vs 2686 +/- 265 cells/mm(2), P<0.001), sub-basal nerve fiber density (31.2 +/- 8.4 nerves/mm(2) vs 18.1 +/- 19.2 nerves/mm(2), P<0.001), sub -basal nerve fiber length (21.4 +/- 3.4 mm/mm(2) vs16.1 +/- 5.1 mm/mm(2), P<0.001), and sub-basal nerve branch density (median 50.0 (first quartile 31.2 - third quartile 68.7) nerve branches/mm(2) vs median 25.0 (first quartile 6.2 - third quartile 45.3) nerve branches/mm(2), P<0.001) were observed in patients with keratocon us. CONCLUSION: Significant microstructural abnormalities were identified in all corneal layers in the eyes of subjects with keratoconus using IVCM. This non invasive in vivo technique provides an important means to define and follow progress of microstructural changes in patients with keratoconus.Öğe The relation of left or right visual acuity and psychologic symptoms in strabismic patients(ELSEVIER SCIENCE BV, 2006) Pence, Sadrettin; Cilli, Ali Savas; Ozkagnici, Ahmet[Abstract not Available]
