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    Effects of pinealectomy and melatonin and steroids supplementation on leptin levels in ovariectomized rats
    (2009) Oztekin, Esma; Mogulkoc, R.; Baltacı, A.K.; Tiftik, A.M.
    The present study was aimed at finding out the relative effects of melatonin and sex steroids on leptin concentrations in ovariectomized rats. This study shows that pinealectomy in ovariectomized rats leads to a significant increase in leptin levels. Estradiol and progesterone supplementation in pinealectomized and ovariectomized rats partly reversed the increase in leptin. Melatonin supplementation completely reversed the increase in leptin.
  • Küçük Resim Yok
    Öğe
    The influence of estradiol and progesterone and melatonin supplementation on TNF-alpha levels in ovariectomized and pinealectomized rats
    (AKADEMIAI KIADO, 2006) Oztekin, Esma; Mogulkoc, R.; Baltaci, A. K.; Tiftik, A. A.
    The aim of this study was to investigate the effect of estradiol and progesterone and melatonin supplementation on TNF-alpha levels in ovariectomized and pinealectomized rats. The study was carried out on 42 adult, Spraque-Dawley strain female rats aged 6 months and weighing 200-250 grams. The rats were divided into 6 groups, each group contained 7 rats. Group 1: Sham-ovariectomized (Sham-Ovx), Group 2: Ovariectomized (Ovx), Group 3: Ovx and estradiol (E) and progesterone (P) supplemented (Ovx+E-P) group, Group 4: Ovx+E-P+Melatonin (M) supplemented group, Group 5: Ovx Pinealectomized (Pnx) group, Group 6: Ovx - Pnx+E-P supplemented group. Serum TNF-alpha levels were determined after 4 weeks application period. Group 6 (Ovx-Pnx+E-P) has the highest serum TNF-alpha compared with other groups while group 2 (ovariectomized), has the lowest levels (P < 0.001). Group 5 was higher than groups 1, 2, 3 and 4 (P < 0.001). The results of the study show that ovariectomy reduces the serum level of TNF-alpha, but estradiol and progesterone application prevents this reduction in ovariectomized rats. However, pinealectomy intensifies the increases in TNF-alpha levels in ovariectomized and estradiol and progesterone supplemented rats, whereas melatonin reduces TNF-alpha levels in ovariectomized rats.