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Öğe Effect of L-thyroxine induced hyperthyroidism on lipid peroxidation in testis and kidney tissues of rats(2007) Baltacl A.K.; Mogulkoc R.; Oztekin E.The present study was conducted to determine lipid peroxidation caused by hyperthyroidism stimulated by 3-weeks L-thyroxin in testis and kidney tissues of rats. Experimental animals were divided into control group 2, sham - hyperthyroidism group; 3, hyperthyroidism group. Malondialdehyde (MDA) and glutathione (GSH) levels were determined in testis and kidney tissues. MDA levels in the testis and kidney were significantly higher in the hyperthyroidism group than in control and sham hyperthyroidism groups (P < 0.001). GSH levels in testis and kidney were also higher in the hyperthyroidism group than those control and sham-hyperthyroidism groups (P < 0.001). The results of the present study demonstrate that the increase is more evident in testis tissue than kidney tissue.Öğe The effects of exogenous estradiol and progesterone with melatonin on homocvsteine levels in ovariectomized rats(2007) Oztekin E.; Mogulkoc R.; Baltaci A.K.; Ozturk B.; Tiftik A.M.The study was carried out an 24 adult, Spraque-Dawfey strain of female rats. Group 1: Control group; Group 2: Ovariectomy group; Group 3 : supplemented with esradiol and progesterone after ovariectomy. Estradiol propionate 450?g/kg and medroxyprogesterone acetate 15mg/kg were supplemented a one time every week and melatonin injection (3mg/kg/rat) was made for four weeks. Serum homocysteine levels in groups 2 and 3 were significantly higher than those in groups 1 and 4. Homocysteine levels in groups 1 and 4 were not different from each other. The findings demonstrate that ovariectomy leads to a significant increase in homocysteine levels, but hormone (estradiol and progesterone) replacement could not prevent this increase. However, this increase was suppressed by exogenous melatonin supplementation.Öğe Effects of zink deficiency and supplementation on some hematologic parameters of rats performing acute swimming exercise(2003) Baltaci A.K.; Ozyurek K.; Mogulkoc R.; Kurtoglu E.; Oztekin E.; Kul A.The aim of the study was to investigate how zinc deficiency and supplementation effect some hematologic parameters of rats performing swimming exercise. Forty adult male Spraque-Dawley rats were divided into 4 groups, zinc deficient swimmimg group (Group 1, n=10), zinc supplemented swimming group (Group 2, n=10), swimming control group (Group 3, n=10), and control group (Group 4, n=10). Blood samples were taken by decapitation and analyzed for the determination of erythrocyte, hemoglobin level, hematocrit, leukocyte, lymphocyte, platelet count and plasma zinc level at the end of the 4 week experiment. Erythrocyte count of group 1 was the lowest whereas erythrocyte count in group 3 was significantly lower than that in group 2 and 4 (p<0,05). Hemoglobin level of group 1 was significantly lower than that of groups 2 and 4 (p<0.05). Hematocrit was significantly lower in both group 1 and group 3 than both groups 2 and 4 (p<0.05). Lymphocyte count in group 2 was significantly higher than in all other groups (p<0.05). Platelet counts in group 2 was significantly lower than in all other groups (p<0.05). Our findings suggest that zinc deficiency effects the hematologic parameters mentioned negatively whereas zinc supplementation has a positive influence.
